Structural and functional brain changes in hepatic and neurological Wilson disease
Tinaz S, Arora J, Nalamada K, Vives-Rodriguez A, Sezgin M, Robakis D, Patel A, Constable RT, Schilsky ML. Structural and functional brain changes in hepatic and neurological Wilson disease. Brain Imaging And Behavior 2020, 15: 2269-2282. PMID: 33244627, DOI: 10.1007/s11682-020-00420-5.Peer-Reviewed Original ResearchConceptsSusceptibility-weighted imagingFunctional brain changesBrain changesWD groupWilson's diseaseWhite matter volume lossBilateral superior frontal cortexBilateral anterior corona radiataResting-state functional MRINeurological Wilson's diseaseStructural brain changesCross-sectional studyGender-matched controlsBrain MRI scansAnterior corona radiataSuperior frontal cortexWhite matter integrityFunctional connectivity analysisSignificant striatalThalamic atrophyNeuropsychiatric symptomsHypointense lesionsTreatment strategiesCorpus callosumNeuropsychiatric assessment