2021
Tet2 Controls the Responses of β cells to Inflammation in Autoimmune Diabetes
Rui J, Deng S, Perdigoto AL, Ponath G, Kursawe R, Lawlor N, Sumida T, Levine-Ritterman M, Stitzel ML, Pitt D, Lu J, Herold KC. Tet2 Controls the Responses of β cells to Inflammation in Autoimmune Diabetes. Nature Communications 2021, 12: 5074. PMID: 34417463, PMCID: PMC8379260, DOI: 10.1038/s41467-021-25367-z.Peer-Reviewed Original ResearchConceptsImmune cellsΒ-cellsNOD/SCID recipientsDiabetogenic immune cellsDiabetogenic T cellsBone marrow transplantType 1 diabetesExpression of TET2Human β-cellsIslet infiltratesSCID recipientsMarrow transplantInflammatory pathwaysTransfer of diseaseT cellsInflammatory genesImmune killingPathologic interactionsReduced expressionDiabetesInflammationTET2MiceRecipientsCells
2010
A novel role for PTEN in the inhibition of neurite outgrowth by myelin-associated glycoprotein in cortical neurons
Perdigoto AL, Chaudhry N, Barnes GN, Filbin MT, Carter BD. A novel role for PTEN in the inhibition of neurite outgrowth by myelin-associated glycoprotein in cortical neurons. Molecular And Cellular Neuroscience 2010, 46: 235-244. PMID: 20869442, PMCID: PMC3018674, DOI: 10.1016/j.mcn.2010.09.006.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCells, CulturedCerebral CortexCHO CellsCoculture TechniquesCricetinaeCricetulusHEK293 CellsHumansMiceMice, Inbred C57BLMice, KnockoutMyelin-Associated GlycoproteinNeuritesNeuronsProto-Oncogene Proteins c-aktPTEN PhosphohydrolaseReceptor, Nerve Growth FactorRho GTP-Binding ProteinsRho-Associated KinasesConceptsCortical neuronsInhibitory effectNeurite outgrowthEffect of MAGP75 neurotrophin receptorPI3K/AKT axisCentral nervous systemPTEN/PI3K/AKT axisAxonal regenerationCorticospinal tractPermanent disabilityNeurotrophin receptorNervous systemAKT axisPhospho-AktNeuronsStriking reductionProcess outgrowthDownstream effector kinasesMyelinInhibitory proteinNovel rolePTENReceptorsNovel pathway