A novel role for PTEN in the inhibition of neurite outgrowth by myelin-associated glycoprotein in cortical neurons
Perdigoto AL, Chaudhry N, Barnes GN, Filbin MT, Carter BD. A novel role for PTEN in the inhibition of neurite outgrowth by myelin-associated glycoprotein in cortical neurons. Molecular And Cellular Neuroscience 2010, 46: 235-244. PMID: 20869442, PMCID: PMC3018674, DOI: 10.1016/j.mcn.2010.09.006.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCells, CulturedCerebral CortexCHO CellsCoculture TechniquesCricetinaeCricetulusHEK293 CellsHumansMiceMice, Inbred C57BLMice, KnockoutMyelin-Associated GlycoproteinNeuritesNeuronsProto-Oncogene Proteins c-aktPTEN PhosphohydrolaseReceptor, Nerve Growth FactorRho GTP-Binding ProteinsRho-Associated KinasesConceptsCortical neuronsInhibitory effectNeurite outgrowthEffect of MAGP75 neurotrophin receptorPI3K/AKT axisCentral nervous systemPTEN/PI3K/AKT axisAxonal regenerationCorticospinal tractPermanent disabilityNeurotrophin receptorNervous systemAKT axisPhospho-AktNeuronsStriking reductionProcess outgrowthDownstream effector kinasesMyelinInhibitory proteinNovel rolePTENReceptorsNovel pathway