FIB-4 Index Is Associated with Hepatocellular Carcinoma Risk in HIV-Infected Patients
Park LS, Tate JP, Justice AC, Lo Re V, Lim JK, Bräu N, Brown ST, Butt AA, Gibert C, Goetz MB, Rimland D, Rodriguez-Barradas MC, Dubrow R. FIB-4 Index Is Associated with Hepatocellular Carcinoma Risk in HIV-Infected Patients. Cancer Epidemiology Biomarkers & Prevention 2011, 20: 2512-2517. PMID: 22028407, PMCID: PMC3237927, DOI: 10.1158/1055-9965.epi-11-0582.Peer-Reviewed Original ResearchConceptsHigh FIB-4C virus infectionFIB-4Hepatocellular carcinomaVirus infectionRisk factorsHigh riskVeterans Affairs Central Cancer RegistryAlcohol abuse/dependencyHIV-1 RNA levelsHepatitis B virus infectionHepatitis C virus infectionVeterans Aging Cohort StudyDevelopment of HCCLow FIB-4Multivariate-adjusted HRNoninvasive laboratory testsAntiretroviral therapy useFIB-4 indexB virus infectionIndependent risk factorHCC risk factorsAging Cohort StudyIncident HCC casesCentral Cancer RegistryHepatic Safety and Antiretroviral Effectiveness in HIV‐Infected Patients Receiving Naltrexone
Tetrault JM, Tate JP, McGinnis KA, Goulet JL, Sullivan LE, Bryant K, Justice AC, Fiellin DA, Team F. Hepatic Safety and Antiretroviral Effectiveness in HIV‐Infected Patients Receiving Naltrexone. Alcohol Clinical And Experimental Research 2011, 36: 318-324. PMID: 21797892, PMCID: PMC3221963, DOI: 10.1111/j.1530-0277.2011.01601.x.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAlanine TransaminaseAlcoholismAntiretroviral Therapy, Highly ActiveAspartate AminotransferasesCD4 Lymphocyte CountChemical and Drug Induced Liver InjuryCohort StudiesDatabases, FactualDrug InteractionsDrug-Related Side Effects and Adverse ReactionsFemaleHIV InfectionsHumansLiverLiver Function TestsMaleMiddle AgedNaltrexoneNarcotic AntagonistsOpioid-Related DisordersRNA, ViralVeteransConceptsNaltrexone prescriptionAlanine aminotransferaseOpioid dependenceVeterans Aging Cohort Study Virtual CohortAspartate aminotransferaseImpact of naltrexoneSignificant alanine aminotransferaseLiver enzyme elevationMean CD4 countHIV-infected individualsAST changesHepatic safetyHIV biomarkersOral naltrexoneCD4 countHIV RNAMedian durationEnzyme elevationMedian ageAST levelsNaltrexone useHepatic enzymesAntiretroviral effectivenessHIVPatientsValidity of diagnostic codes and liver‐related laboratory abnormalities to identify hepatic decompensation events in the Veterans Aging Cohort Study
Re V, Lim JK, Goetz MB, Tate J, Bathulapalli H, Klein MB, Rimland D, Rodriguez‐Barradas M, Butt AA, Gibert CL, Brown ST, Kidwai F, Brandt C, Dorey‐Stein Z, Reddy KR, Justice AC. Validity of diagnostic codes and liver‐related laboratory abnormalities to identify hepatic decompensation events in the Veterans Aging Cohort Study. Pharmacoepidemiology And Drug Safety 2011, 20: 689-699. PMID: 21626605, PMCID: PMC3131229, DOI: 10.1002/pds.2148.Peer-Reviewed Original ResearchConceptsVeterans Aging Cohort StudyHepatic decompensation eventsPositive predictive valueHigh positive predictive valueLaboratory abnormalitiesAging Cohort StudyDecompensation eventsDiagnostic codesCohort studyHepatic decompensationVariceal hemorrhageOutpatient diagnostic codesChronic liver diseaseSpontaneous bacterial peritonitisImpact of medicationLiver dysfunctionBacterial peritonitisLiver diseaseMedical recordsOutpatient codesPredictive valueNatural historyAbnormalitiesEpidemiologic researchPatients