2019
Association of immunosuppression and HIV viraemia with non-Hodgkin lymphoma risk overall and by subtype in people living with HIV in Canada and the USA: a multicentre cohort study
Hernández-Ramírez RU, Qin L, Lin H, Leyden W, Neugebauer RS, Althoff KN, Achenbach CJ, Hessol NA, D'Souza G, Gebo KA, Gill MJ, Grover S, Horberg MA, Li J, Mathews WC, Mayor AM, Park LS, Rabkin CS, Salters K, Justice AC, Moore RD, Engels EA, Silverberg MJ, Dubrow R, AIDS N, Betts A, Brooks J, Freeman A, Van Rompaey S, Burchell A, Yip B, You B, Hogan B, Grasso C, Hogg R, Benson C, Drozd D, Sterling T, Haas D, Humes E, Crane H, Willig J, Eron J, Martin J, Saag M, Jing J, Zhang J, Lindsay J, Hunter-Mellado R, Deeks S, Zhu J, Montaner J, McReynolds J, Gabler K, Buchacz K, Rodriguez B, Thorne J, Margolick J, Anastos K, Jacobson L, Klein M, Kroch A, Morton L, Turner M, Fiellin D, Gange S, Mugavero M, Harrigan P, Rebeiro P, Bosch R, Kirk G, Mayer K, McKaig R, Coburn S, Napravnik S, Kitahata M, Lober W, Lee J. Association of immunosuppression and HIV viraemia with non-Hodgkin lymphoma risk overall and by subtype in people living with HIV in Canada and the USA: a multicentre cohort study. The Lancet HIV 2019, 6: e240-e249. PMID: 30826282, PMCID: PMC6531288, DOI: 10.1016/s2352-3018(18)30360-6.Peer-Reviewed Original ResearchConceptsNon-Hodgkin lymphomaRecent CD4 countCD4 countHIV viraemiaKey independent predictorsViral loadIndependent predictorsNorth American AIDS Cohort CollaborationCNS non-Hodgkin's lymphomaOverall non-Hodgkin lymphomaDiffuse large B-cell lymphomaLarge B-cell lymphomaAssociation of immunosuppressionMulticentre cohort studyNon-Hodgkin lymphoma (NHL) riskAverage viral loadUS Health ResourcesB-cell lymphomaOverall immune functionB cell activationLong-term careCohort CollaborationRecent immunosuppressionAntiretroviral therapyCohort study
2017
HIV Infection, Immunosuppression, and Age at Diagnosis of Non-AIDS-Defining Cancers
Shiels MS, Althoff KN, Pfeiffer RM, Achenbach CJ, Abraham AG, Castilho J, Cescon A, D’Souza G, Dubrow R, Eron JJ, Gebo K, Gill M, Goedert JJ, Grover S, Hessol NA, Justice A, Kitahata M, Mayor A, Moore RD, Napravnik S, Novak RM, Thorne JE, Silverberg MJ, Engels EA, AIDS F. HIV Infection, Immunosuppression, and Age at Diagnosis of Non-AIDS-Defining Cancers. Clinical Infectious Diseases 2017, 64: 468-475. PMID: 27940936, PMCID: PMC5850313, DOI: 10.1093/cid/ciw764.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsAgedCD4 Lymphocyte CountCohort StudiesFemaleHIV InfectionsHumansImmune ToleranceMaleMiddle AgedNeoplasmsYoung AdultConceptsOral cavity/pharynxYounger ageCancer diagnosisCD4 countMedian ageLung cancerKidney cancerGeneral populationNorth American AIDS Cohort CollaborationMost cancersEnd Results ProgramHuman immunodeficiency virusRisk factor exposureLung cancer diagnosisAccelerated cancer progressionCohort CollaborationNon-AIDSAnal cancerHIV infectionImmunodeficiency virusResults ProgramMyeloma diagnosisPLWHAIDS statusCancer