2016
Do Biomarkers of Inflammation, Monocyte Activation, and Altered Coagulation Explain Excess Mortality Between HIV Infected and Uninfected People?
So-Armah KA, Tate JP, Chang CH, Butt AA, Gerschenson M, Gibert CL, Leaf D, Rimland D, Rodriguez-Barradas MC, Budoff MJ, Samet JH, Kuller LH, Deeks SG, Crothers K, Tracy RP, Crane HM, Sajadi MM, Tindle HA, Justice AC, Freiberg MS. Do Biomarkers of Inflammation, Monocyte Activation, and Altered Coagulation Explain Excess Mortality Between HIV Infected and Uninfected People? JAIDS Journal Of Acquired Immune Deficiency Syndromes 2016, 72: 206-213. PMID: 27824677, PMCID: PMC4867134, DOI: 10.1097/qai.0000000000000954.Peer-Reviewed Original ResearchConceptsBiomarkers of inflammationD-dimerIL-6Uninfected peopleMortality riskHIV infectionMonocyte activationVeterans Aging Cohort Study Biomarker CohortCox proportional hazards regressionElevated IL-6Excess mortality riskProportional hazards regressionUnsuppressed viremiaComorbid diseasesBiomarker cohortHighest quartileHIV statusHazards regressionExcess riskBlood drawExcess mortalityImmunologic processesSCD14Mortality rateLogistic regression
2012
HIV Status, Burden of Comorbid Disease, and Biomarkers of Inflammation, Altered Coagulation, and Monocyte Activation
Armah KA, McGinnis K, Baker J, Gibert C, Butt AA, Bryant KJ, Goetz M, Tracy R, Oursler KK, Rimland D, Crothers K, Rodriguez-Barradas M, Crystal S, Gordon A, Kraemer K, Brown S, Gerschenson M, Leaf DA, Deeks SG, Rinaldo C, Kuller LH, Justice A, Freiberg M. HIV Status, Burden of Comorbid Disease, and Biomarkers of Inflammation, Altered Coagulation, and Monocyte Activation. Clinical Infectious Diseases 2012, 55: 126-136. PMID: 22534147, PMCID: PMC3493182, DOI: 10.1093/cid/cis406.Peer-Reviewed Original ResearchConceptsBiomarkers of inflammationVeterans Aging Cohort StudyAltered coagulationMonocyte activationUninfected veteransCardiovascular diseaseElevated biomarkersComorbid conditionsHigh prevalenceCD4 cell countElevated IL-6Aging Cohort StudyOngoing HIV replicationPrevalent cardiovascular diseaseHIV-1 RNAHuman immunodeficiency virusCopies/mLElevated sCD14More dyslipidemiaCD4 countHepatitis CCohort studyComorbid diseasesCurrent smokingHIV infectionDoes an Index Composed of Clinical Data Reflect Effects of Inflammation, Coagulation, and Monocyte Activation on Mortality Among Those Aging With HIV?
Justice AC, Freiberg MS, Tracy R, Kuller L, Tate JP, Goetz MB, Fiellin DA, Vanasse GJ, Butt AA, Rodriguez-Barradas MC, Gibert C, Oursler KA, Deeks SG, Bryant K, Team T. Does an Index Composed of Clinical Data Reflect Effects of Inflammation, Coagulation, and Monocyte Activation on Mortality Among Those Aging With HIV? Clinical Infectious Diseases 2012, 54: 984-994. PMID: 22337823, PMCID: PMC3297653, DOI: 10.1093/cid/cir989.Peer-Reviewed Original ResearchConceptsHIV-1 RNANet reclassification improvementHepatitis C virusD-dimerIL-6VACS IndexMonocyte activationVeterans Aging Cohort Study (VACS) IndexHuman immunodeficiency virus type 1 (HIV-1) RNAFIB-4 indexGlomerular filtration rateMarkers of liverRoutine clinical variablesCopies/mLPrediction of mortalityEffects of inflammationHCV statusAntiretroviral therapyCD4 countRenal injuryReclassification improvementClinical variablesC-statisticC virusFiltration rate