2020
DNA methylation signature on phosphatidylethanol, not on self-reported alcohol consumption, predicts hazardous alcohol consumption in two distinct populations
Liang X, Justice AC, So-Armah K, Krystal JH, Sinha R, Xu K. DNA methylation signature on phosphatidylethanol, not on self-reported alcohol consumption, predicts hazardous alcohol consumption in two distinct populations. Molecular Psychiatry 2020, 26: 2238-2253. PMID: 32034291, PMCID: PMC8440221, DOI: 10.1038/s41380-020-0668-x.Peer-Reviewed Original ResearchConceptsHazardous alcohol drinkingSelf-reported alcohol consumptionAlcohol consumptionCohort 2Cohort 1Epigenome-wide association studiesSelf-reported dataHazardous alcohol consumptionAlcohol use disorderDNAm signaturesObjective measuresAlcohol drinkingClinical assessmentUse disordersRobust biomarkersDNA methylation signaturesValidation setDistinct populationsCharacteristic curvePEthEpigenetic biomarkersMethylation signatures
1999
The Relationship Between Clinical Assessments of Nutritional Status and Adverse Outcomes in Older Hospitalized Medical Patients
Covinsky K, Martin G, Beyth R, Justice A, Sehgal A, Landefeld C. The Relationship Between Clinical Assessments of Nutritional Status and Adverse Outcomes in Older Hospitalized Medical Patients. Journal Of The American Geriatrics Society 1999, 47: 532-538. PMID: 10323645, DOI: 10.1111/j.1532-5415.1999.tb02566.x.Peer-Reviewed Original ResearchConceptsNursing home useAcute illness severityAdverse outcomesIllness severityNutritional statusClinical assessmentMalnourished patientsHospital admissionSubjective Global AssessmentProspective cohort studyTertiary care hospitalHome useIndex of comorbidityGeneral medical servicesPhysical exam findingsHospitalized older peopleYear of dischargeLogistic regression modelsNourished patientsSurrogate interviewsHospital outcomesChart reviewCohort studyCare hospitalHospitalized patients