2015
Do Alcohol Misuse, Smoking, and Depression Vary Concordantly or Sequentially? A Longitudinal Study of HIV-Infected and Matched Uninfected Veterans in Care
Braithwaite RS, Fang Y, Tate J, Mentor SM, Bryant KJ, Fiellin DA, Justice AC. Do Alcohol Misuse, Smoking, and Depression Vary Concordantly or Sequentially? A Longitudinal Study of HIV-Infected and Matched Uninfected Veterans in Care. AIDS And Behavior 2015, 20: 566-572. PMID: 26187007, PMCID: PMC5009622, DOI: 10.1007/s10461-015-1117-8.Peer-Reviewed Original ResearchConceptsHarmful alcohol useAlcohol misuseCurrent smokingVeterans Aging Cohort StudyAlcohol useAging Cohort StudyUninfected veteransCohort studyHIV statusDepression variesChronic diseasesCommon syndromePrior depressionSmokingUninfected individualsCurrent depressionHIVDepressionLongitudinal studyRegression analysisCareVeteransMisuseSame surveyNumber of years
2014
HIV infection, antiretroviral therapy initiation and longitudinal changes in biomarkers of organ function.
So-Armah KA, Chang J, Alcorn C, Lo Re V, Baker JV, Tracy R, Butt AA, Agan BK, Rimland D, Gibert CL, Goetz MB, Oursler KK, Rodriguez-Barradas MC, Kuller LH, Brown ST, Stein JH, Skanderson M, Justice AC, Freiberg MS. HIV infection, antiretroviral therapy initiation and longitudinal changes in biomarkers of organ function. Current HIV Research 2014, 12: 50-9. PMID: 25034208, PMCID: PMC4495647, DOI: 10.2174/1570162x1201140716101512.Peer-Reviewed Original ResearchConceptsART initiationHIV infectionHIV infection levelsViral suppressionLongitudinal changesLDL cholesterolPositive HIV antibody testBiomarker measurementsAge-related chronic diseasesAntiretroviral therapy initiationEnd-organ diseaseFIB-4 scoreHIV antibody testWilcoxon signedrank testUninfected veteransVACS-VCFIB-4Therapy initiationHIV levelsHDL cholesterolSerum levelsTotal cholesterolPlatelet countMean ageChronic diseases
2013
Management of Human Immunodeficiency Virus Infection in Advanced Age
Greene M, Justice AC, Lampiris HW, Valcour V. Management of Human Immunodeficiency Virus Infection in Advanced Age. JAMA 2013, 309: 1397-1405. PMID: 23549585, PMCID: PMC3684249, DOI: 10.1001/jama.2013.2963.Peer-Reviewed Original ResearchConceptsHIV-positive patientsOlder HIV-positive patientsHuman immunodeficiency virus (HIV) infectionHIV-negative counterpartsComorbid medical illnessesHIV-negative patientsComorbid medical conditionsImmunodeficiency virus infectionHuman immunodeficiency virusLife expectancyMultiple comorbid diseasesLonger life expectancyAntiretroviral regimenOlder HIVAntiretroviral therapyComorbid diseasesConcomitant diseasesPositive patientsMedical illnessImmunodeficiency virusAdvanced ageChronic diseasesChronic illnessConsensus statementVirus infection
2012
HIV infection, aging, and immune function
Dubrow R, Silverberg MJ, Park LS, Crothers K, Justice AC. HIV infection, aging, and immune function. Current Opinion In Oncology 2012, 24: 506-516. PMID: 22759737, PMCID: PMC3695478, DOI: 10.1097/cco.0b013e328355e131.Peer-Reviewed Original ResearchConceptsAntiretroviral therapyHIV infectionCancer riskCancer preventionMore effective antiretroviral therapySustained antiretroviral therapyCombination antiretroviral therapyEffective antiretroviral therapyCancer risk factorsComplex chronic diseaseImmune system effectsSpecific cancer typesSystemic inflammationImmune dysfunctionChronic inflammationViral causeSmoking effectsLung cancerIndependent associationRisk factorsChronic diseasesHigh prevalenceCancer spectrumLiver cancerElevated risk
2010
HIV and Aging: Time for a New Paradigm
Justice A. HIV and Aging: Time for a New Paradigm. Current HIV/AIDS Reports 2010, 7: 69-76. PMID: 20425560, DOI: 10.1007/s11904-010-0041-9.Peer-Reviewed Original ResearchConceptsHIV infectionNon-AIDS diseasesCombination antiretroviral therapyPopulation of patientsCause of morbidityComplex chronic diseaseSpectrum of diseaseProlong life expectancyAntiretroviral therapyCD4 countHIV RNAViral suppressionFunctional statusChronic diseasesPatient riskOptimal managementHIVInfectionLife expectancyDiseaseMorbidityMortalityAIDSRiskPatients
2008
Workshop on HIV Infection and Aging: What Is Known and Future Research Directions
High K, Effros R, Fletcher C, Gebo K, Halter J, Hazzard W, Horne F, Huebner R, Janoff E, Justice A, Kuritzkes D, Nayfield S, Plaeger S, Schmader K, Ashworth J, Campanelli C, Clayton C, Rada B, Woolard N, High K. Workshop on HIV Infection and Aging: What Is Known and Future Research Directions. Clinical Infectious Diseases 2008, 47: 542-553. PMID: 18627268, PMCID: PMC3130308, DOI: 10.1086/590150.Peer-Reviewed Original ResearchConceptsHIV infectionHuman immunodeficiency virus (HIV) infectionInfectious diseasesImmunodeficiency virus infectionInfectious Diseases SocietyActive antiretroviral treatmentNational InstituteDiseases SocietyAntiretroviral treatmentImmunodeficiency syndromeAdvanced ageChronic diseasesVirus infectionDrug toxicityInfectionSpecialty ProfessorsLife expectancyDiseaseComorbiditiesMedical AssociationHigh-priority topicsTreatmentAssociationAging processPriority topics
2001
Justification for a new cohort study of people aging with and without HIV infection
Justice AC, Landefeld CS, Asch SM, Gifford AL, Whalen CC, Covinsky KE. Justification for a new cohort study of people aging with and without HIV infection. Journal Of Clinical Epidemiology 2001, 54: s3-s8. PMID: 11750202, PMCID: PMC6563331, DOI: 10.1016/s0895-4356(01)00440-1.Peer-Reviewed Original ResearchConceptsVeterans Aging Cohort StudyCohort studyChronic diseasesAging Cohort StudyLongitudinal cohort studyNew cohort studiesHIV/AIDSSubstance use/abuseUse/abuseNegative patientsHIV infectionOrgan injuryComorbid conditionsIatrogenic injuryDrug toxicityVeteran populationMethodologic issuesHIVDiseaseInjuryPopulationPatientsEtiologyInfectionStudy