2024
Stress and inflammation target dorsolateral prefrontal cortex function: Neural mechanisms underlying weakened cognitive control
Joyce M, Uchendu S, Arnsten A. Stress and inflammation target dorsolateral prefrontal cortex function: Neural mechanisms underlying weakened cognitive control. Biological Psychiatry 2024 PMID: 38944141, DOI: 10.1016/j.biopsych.2024.06.016.Peer-Reviewed Original ResearchMental disordersDorsolateral prefrontal cortex functionPrefrontal cortex functionSubgenual cingulate cortexRegulate emotional responsesDorsolateral prefrontal cortexChronic stress exposurePosterior association cortexMedial PFCCognitive controlPrefrontal cortexWorking memoryCingulate cortexRegulate attentionCortex functionNeural mechanismsDlPFCBrain regionsStress exposureAssociation cortexTop-down projectionsEmotional responsesSpine lossArousal statePersistent firing
2022
The Aversive Lens: Stress effects on the prefrontal-cingulate cortical pathways that regulate emotion
Arnsten A, Joyce M, Roberts A. The Aversive Lens: Stress effects on the prefrontal-cingulate cortical pathways that regulate emotion. Neuroscience & Biobehavioral Reviews 2022, 145: 105000. PMID: 36529312, PMCID: PMC9898199, DOI: 10.1016/j.neubiorev.2022.105000.Peer-Reviewed Original ResearchConceptsCortical pathwaysStress exposureDendritic spine lossChronic stress exposureAnti-depressant treatmentDeep brain stimulationPrefrontal cortical areasExcessive dopamineNeuromodulatory treatmentSSRI medicationNorepinephrine releaseSpine lossSubgenual cingulateCortical areasBrain stimulationChronic stressBA25MedicationsDorsolateral PFCTreatmentExposurePsychic painPainKetamineSymptoms