Association Between Immunoparesis and Treatment Outcomes of Patients With Newly Diagnosed Multiple Myeloma: A Systematic Review and Meta-Analysis
Siwakoti A, Khadka S, Grimshaw A, Giri S. Association Between Immunoparesis and Treatment Outcomes of Patients With Newly Diagnosed Multiple Myeloma: A Systematic Review and Meta-Analysis. Clinical Lymphoma Myeloma & Leukemia 2024, 24: e870-e877. PMID: 39179448, DOI: 10.1016/j.clml.2024.07.008.Peer-Reviewed Original ResearchNewly diagnosed multiple myelomaProgression free survivalImpact of immunoparesisVisual examination of funnel plotsAssociated with worse OSOverall survivalMultiple myelomaFree survivalPrognostic impactPre-published protocolFunnel plotMeta-analysisHazard ratioTreatment outcomes of patientsPublication biasOutcomes of patientsContour-enhanced funnel plotsImmune system perturbationsInfection rateCause of mortalityInfection riskMicro AbstractClinical outcomesImmunoparesisPolyclonal immunoglobulinsLow skeletal muscle mass and treatment outcomes among adults with haematologic malignancies: A systematic review and meta‐analysis
Anabtawi N, Pasala M, Grimshaw A, Kharel P, Bal S, Godby K, Siwakoti A, Buford T, Bhatia S, Costa L, Williams G, Giri S. Low skeletal muscle mass and treatment outcomes among adults with haematologic malignancies: A systematic review and meta‐analysis. Journal Of Cachexia Sarcopenia And Muscle 2024, 15: 1084-1093. PMID: 38558541, PMCID: PMC11154774, DOI: 10.1002/jcsm.13446.Peer-Reviewed Original ResearchConceptsLow skeletal muscle massNon-relapse mortalityProgression free survivalTreatment-related toxicityHaematological malignanciesOverall survivalSkeletal muscle massMuscle massEffects of low skeletal muscle massImpact of low skeletal muscle massIncreased risk of treatment-related toxicityPresence of low skeletal muscle massRisk of treatment-related toxicityHazard ratioAssociated with worse survival outcomesAssociated with worse OSDerSimonian-Laird random-effects modelModerate heterogeneityInferior overall survivalWorse survival outcomesConfidence intervalsRandom-effects modelFree survivalSolid malignanciesPre-published protocol