2024
Investigating the overlapping presentation of irritable bowel syndrome and vulvodynia: a scoping review of the evidence and mechanisms
Perelmuter S, Soogoor A, Maliszewski K, Grimshaw A. Investigating the overlapping presentation of irritable bowel syndrome and vulvodynia: a scoping review of the evidence and mechanisms. Sexual Medicine Reviews 2024, 12: 559-568. PMID: 39084679, DOI: 10.1093/sxmrev/qeae053.Peer-Reviewed Original ResearchIrritable bowel syndromeDiagnostic delayPresentation of irritable bowel syndromeQuasi-experimental studyInception of databasesIncreased risk of sexual dysfunctionCross-sectional studyCase-control studyBowel syndromeRisk of sexual dysfunctionWeb of ScienceSignificant diagnostic delayImprove screeningMultifactorial medical conditionIBS diagnosisCohort studyMedical conditionsReduced qualityMast cell involvementCochrane LibraryComprehensive searchScience DirectIncreased likelihoodIncreased riskGoogle ScholarSystematic review: The use of large language models as medical chatbots in digestive diseases
Giuffrè M, Kresevic S, You K, Dupont J, Huebner J, Grimshaw A, Shung D. Systematic review: The use of large language models as medical chatbots in digestive diseases. Alimentary Pharmacology & Therapeutics 2024, 60: 144-166. PMID: 38798194, DOI: 10.1111/apt.18058.Peer-Reviewed Original ResearchLanguage modelAdverse patient safety eventsPatient safety eventsClinical decision supportRisk of biasSystematic literature searchWeb of Science Core CollectionCombination of keywordsMedical chatbotTriage recommendationsHealthcare systemScience Core CollectionNecessary careSafety eventsOverburden healthcare systemsMedical adviceOvid MEDLINEMultiple specialtiesDecision supportOvid EmbaseCochrane LibrarySingle-study resultsGoogle ScholarLiterature searchGastroenterologyGender Disparity in Full Professor Rank Among Academic Physicians: A Systematic Review and Meta-Analysis
Marhoffer E, Ein-Alshaeba S, Grimshaw A, Holleck J, Rudikoff B, Bastian L, Gunderson C. Gender Disparity in Full Professor Rank Among Academic Physicians: A Systematic Review and Meta-Analysis. Academic Medicine 2024, 99: 801-809. PMID: 38498314, DOI: 10.1097/acm.0000000000005695.Peer-Reviewed Original ResearchSystematic reviewAcademic Search PremierMeta-analysisMedical school facultyGender disparitiesWeb of SciencePooled aORUnadjusted ORInternal medicineOdds ratioAcademic physiciansStatistical heterogeneityInclusion criteriaUnited StatesMeta-regressionSystematic searchPrimary outcomeAORCochrane LibraryAcademic medicineGoogle ScholarDisparitiesGrant fundingSchool facultyWomen
2023
Endometrial responses to bacterial and viral infection: a scoping review.
Lindsay C, Potter J, Grimshaw A, Abrahams V, Tong M. Endometrial responses to bacterial and viral infection: a scoping review. Human Reproduction Update 2023, 29: 675-693. PMID: 37290428, PMCID: PMC10477945, DOI: 10.1093/humupd/dmad013.Peer-Reviewed Original ResearchConceptsEndometrial responseViral infectionUterus/endometriumFull-text studiesInnate immune sensingInnate immune responseFree-text termsEmbase/MedlineIntrauterine infectionObstetric complicationsEndometrial productionCochrane LibraryFuture studiesImplantation failureNeisseria gonorrheaImmune cellsMost infectionsImmune responseUterine functionChlamydia trachomatisAnimal modelsImmune sensingEndometriumZika virusMajority of studiesOffspring neurodevelopmental outcomes born to parents with chronic inflammatory arthritis using antirheumatic therapies: A scoping review
Chock E, Dahal S, Grimshaw A, Suter L, Liew Z, Felson D. Offspring neurodevelopmental outcomes born to parents with chronic inflammatory arthritis using antirheumatic therapies: A scoping review. Seminars In Arthritis And Rheumatism 2023, 61: 152230. PMID: 37295300, PMCID: PMC10521166, DOI: 10.1016/j.semarthrit.2023.152230.Peer-Reviewed Original ResearchConceptsChronic inflammatory arthritisOffspring neurodevelopmental outcomesAntirheumatic therapyNeurodevelopmental outcomesInflammatory arthritisTumor necrosis factor-alpha inhibitorsNecrosis factor-alpha inhibitorsNonsteroidal anti-inflammatory drugsEarly first trimesterOffspring health outcomesAnti-inflammatory drugsMeta-Analyses (PRISMA) guidelinesPreferred Reporting ItemsWeb of ScienceAttention deficit hyperactive disorderCorticosteroid useRheumatic diseasesFirst trimesterCochrane LibraryAlpha inhibitorsStudy qualityMedication safetyFetal wellbeingIndependent reviewersMost womenBurden of bone disease in chronic pancreatitis: A systematic review and meta-analysis
Chhoda A, Hernandez-Woodbine M, Addo N, Nasir S, Grimshaw A, Gunderson C, Ahmed A, Freedman S, Sheth S. Burden of bone disease in chronic pancreatitis: A systematic review and meta-analysis. World Journal Of Gastroenterology 2023, 29: 1374-1394. PMID: 36925454, PMCID: PMC10011962, DOI: 10.3748/wjg.v29.i8.1374.Peer-Reviewed Original ResearchConceptsPrevalence of osteopeniaChronic pancreatitisFragility fracturesBone diseaseCP patientsClinical featuresPooled prevalenceSystematic reviewBaseline clinical featuresSignificant bone diseasePrevalence of osteoporosisBody mass indexCause of morbidityBone mineralization parametersRandom-effects modelPaucity of dataWeb of SciencePERT useSmoking exposureSystemic inflammationTherapy useMass indexTrue burdenCochrane LibraryMean ageOvarian absence: a systematic literature review and case series report
Chen H, Grimshaw A, Taylor-Giorlando M, Vijayakumar P, Li D, Margetts M, Pelosi E, Vash-Margita A. Ovarian absence: a systematic literature review and case series report. Journal Of Ovarian Research 2023, 16: 13. PMID: 36642704, PMCID: PMC9841619, DOI: 10.1186/s13048-022-01090-1.Peer-Reviewed Original ResearchConceptsOvarian absenceUterine abnormalitiesVascular accidentRenal abnormalitiesInfertility/subfertilityCase series reportWeb of SciencePelvic painDiagnostic laparoscopyClinical presentationVascular etiologyOvid EmbaseCochrane LibraryFrequent presentationUncommon conditionSeries reportCongenital anomaliesOvid MEDLINEOvarian abnormalitiesFertility considerationsGenitourinary anatomyExclusion criteriaEmbryological defectUnpublished casesSystematic review
2022
Randomized Clinical Trials of Machine Learning Interventions in Health Care
Plana D, Shung DL, Grimshaw AA, Saraf A, Sung JJY, Kann BH. Randomized Clinical Trials of Machine Learning Interventions in Health Care. JAMA Network Open 2022, 5: e2233946. PMID: 36173632, PMCID: PMC9523495, DOI: 10.1001/jamanetworkopen.2022.33946.Peer-Reviewed Original ResearchConceptsRandomized clinical trialsRisk of biasClinical trialsSystematic reviewNon-RCT designHealth careCONSORT-AIClinical adoptionCochrane riskOvid EmbaseCochrane LibraryTrial characteristicsOvid MEDLINEPrimary interventionExclusion criteriaCommon reasonMedian proportionPatient careRCT designLiterature searchOverall riskRelevant articlesLack of participantsTrialsGoogle ScholarThe Medical Community’s Evolving Focus on Physician and Surgeon Pregnancy: Thematic Trends From a Scoping Review
Hanchuk S, Casilla-Lennon M, Zheng S, Kim DD, Press B, Nguyen JV, Grimshaw A, Leapman MS, Rickey LM, Cavallo JA. The Medical Community’s Evolving Focus on Physician and Surgeon Pregnancy: Thematic Trends From a Scoping Review. Academic Medicine 2022, 97: 1071-1078. PMID: 35171119, PMCID: PMC9247020, DOI: 10.1097/acm.0000000000004629.Peer-Reviewed Original ResearchConceptsPhysician pregnancyMulti-institutional prospective observational studyDefinitive evidence-based recommendationsMaternal-fetal health outcomesProspective observational studyImpact of pregnancyEvidence-based recommendationsFull-text reviewOvid EmbaseCochrane LibraryPhysician specialtyObservational studyOvid MEDLINEInclusion criteriaStudy populationPregnancyHealth outcomesPhysiciansCommunity studySurgical specialtiesGoogle ScholarWork productivityWomen physiciansScoping ReviewPublication yearBenefit of Extended Surveillance of Low-Risk Pancreatic Cysts After 5-Year Stability: A Systematic Review and Meta-Analysis
Chhoda A, Singh S, Sheth AH, Grimshaw AA, Gunderson C, Sharma P, Kunstman JW, Sharma A, Ahuja N, Gonda TA, Farrell JJ. Benefit of Extended Surveillance of Low-Risk Pancreatic Cysts After 5-Year Stability: A Systematic Review and Meta-Analysis. Clinical Gastroenterology And Hepatology 2022, 21: 1430-1446. PMID: 35568304, DOI: 10.1016/j.cgh.2022.04.025.Peer-Reviewed Original ResearchConceptsDisease-specific mortalityAdvanced neoplasiaBD-IPMNsExtended surveillancePooled incidenceWorrisome featuresSystematic reviewIntraductal papillary mucinous neoplasmHigh-grade dysplasiaPapillary mucinous neoplasmHigh-quality studiesRandom-effects modelWarrants further investigationWeb of ScienceNeoplasia incidenceWarrants further explorationSurvival benefitCochrane LibraryMucinous neoplasmsPancreatic cancerPancreatic cystsSurveillance periodEligible studiesOvid MEDLINELower incidence
2021
Late-Stage Pancreatic Cancer Detected During High-Risk Individual Surveillance: A Systematic Review and Meta-Analysis
Chhoda A, Vodusek Z, Wattamwar K, Mukherjee E, Gunderson C, Grimshaw A, Sharma A, Ahuja N, Kastrinos F, Farrell JJ. Late-Stage Pancreatic Cancer Detected During High-Risk Individual Surveillance: A Systematic Review and Meta-Analysis. Gastroenterology 2021, 162: 786-798. PMID: 34813861, DOI: 10.1053/j.gastro.2021.11.021.Peer-Reviewed Original ResearchConceptsLate-stage PDACPancreatic ductal adenocarcinomaHigh-risk individualsHigh-grade precursorsCumulative incidenceAdvanced neoplasiaLate-stage pancreatic cancerTiming of presentationRandom-effects modelWeb of ScienceClinicoradiologic factorsClinicoradiologic featuresSurveillance imagingCochrane LibraryPancreatic cancerDuctal adenocarcinomaPancreatic morphologySurveillance studyFunnel plotLesion sitePDAC stagesSurveillance adherenceSystematic reviewMeta-AnalysisSignificant associationAntiplatelet Monotherapy Is Associated with an Increased Risk of Bleeding After Endoscopic Sphincterotomy
Zakko A, Zakko L, Grimshaw AA, Laine L. Antiplatelet Monotherapy Is Associated with an Increased Risk of Bleeding After Endoscopic Sphincterotomy. Digestive Diseases And Sciences 2021, 67: 4161-4169. PMID: 34796411, DOI: 10.1007/s10620-021-07302-w.Peer-Reviewed Original ResearchConceptsEndoscopic retrograde cholangiopancreatographyPost-sphincterotomy bleedingAntiplatelet monotherapyInclusion criteriaRisk of bleedingROBINS-I toolNewcastle-Ottawa ScaleHigh-quality studiesRandom-effects modelBackgroundClinical guidelinesAntithrombotic therapyAdult patientsCohort studyEndoscopic sphincterotomyPrimary outcomeAntiplatelet agentsOvid EmbaseRetrograde cholangiopancreatographyCochrane LibraryOvid MEDLINEMonotherapyMethodological qualityBleedingUnique citationsPatientsRisk of Intestinal Necrosis With Sodium Polystyrene Sulfonate: A Systematic Review and Meta‐analysis
Holleck JL, Roberts AE, Marhoffer EA, Grimshaw AA, Gunderson CG. Risk of Intestinal Necrosis With Sodium Polystyrene Sulfonate: A Systematic Review and Meta‐analysis. Journal Of Hospital Medicine 2021, 16: 489-494. PMID: 34328838, DOI: 10.12788/jhm.3655.Peer-Reviewed Original ResearchConceptsSevere gastrointestinal side effectsGastrointestinal side effectsIntestinal necrosisHazard ratioSide effectsComposite outcomeOdds ratioSodium polystyrene sulfonateSystematic reviewSevere gastrointestinal adverse eventsGastrointestinal adverse eventsPooled hazard ratioRisk of biasPooled odds ratioCase-control studyPrior systematic reviewsSystematic literature searchAdverse eventsAlternative medicationsCochrane LibraryDatabase inceptionClinical trialsNecrosis rateInclusion criteriaPotential confoundingEvaluation of diagnostic yield of EUS among patients with asymptomatic common bile duct dilation: systematic review and meta-analysis
Chhoda A, Dawod S, Grimshaw A, Gunderson C, Mahadev S. Evaluation of diagnostic yield of EUS among patients with asymptomatic common bile duct dilation: systematic review and meta-analysis. Gastrointestinal Endoscopy 2021, 94: 890-901.e8. PMID: 34245751, DOI: 10.1016/j.gie.2021.07.002.Peer-Reviewed Original ResearchConceptsCommon bile duct dilationBile duct dilationAsymptomatic patientsBiliary dilationDiagnostic yieldCBD dilationDuct dilationEUS evaluationSystematic reviewHealth resource utilizationInverse variance methodRandom-effects modelCost-effectiveness analysisRadiologic evidenceBenign etiologyMalignant etiologyFrequent indicationOvid EmbaseAsymptomatic individualsCochrane LibraryMalignant pathologyOvid MEDLINEFurther interventionPatientsGoogle Scholar
2020
Evaluation of Daratumumab for the Treatment of Multiple Myeloma in Patients With High-risk Cytogenetic Factors
Giri S, Grimshaw A, Bal S, Godby K, Kharel P, Djulbegovic B, Dimopoulos MA, Facon T, Usmani SZ, Mateos MV, Costa LJ. Evaluation of Daratumumab for the Treatment of Multiple Myeloma in Patients With High-risk Cytogenetic Factors. JAMA Oncology 2020, 6: 1759-1765. PMID: 32970151, PMCID: PMC7516804, DOI: 10.1001/jamaoncol.2020.4338.Peer-Reviewed Original ResearchConceptsProgression-free survivalHigh-risk MMBackbone regimensRefractory MMHazard ratioMultiple myelomaClinical trialsSystematic reviewDerSimonian-Laird random-effects modelPhase 3 trialImproved response ratesPreferred Reporting ItemsRandom-effects modelCochrane riskSame regimenCytogenetic riskCochrane LibraryMeeting libraryI2 statisticImproved outcomesMAIN OUTCOMEThird investigatorCochran's QPatientsReporting ItemsPrevalence of harmful diagnostic errors in hospitalised adults: a systematic review and meta-analysis
Gunderson CG, Bilan VP, Holleck JL, Nickerson P, Cherry BM, Chui P, Bastian LA, Grimshaw AA, Rodwin BA. Prevalence of harmful diagnostic errors in hospitalised adults: a systematic review and meta-analysis. BMJ Quality & Safety 2020, 29: 1008-1018. PMID: 32269070, DOI: 10.1136/bmjqs-2019-010822.Peer-Reviewed Original ResearchConceptsAdverse eventsDiagnostic errorsPhysician reviewSystematic reviewInpatient adverse eventsRisk of biasPatient safety hazardsSystem-related factorsSystematic literature searchWeb of SciencePulmonary embolismAdult patientsCase seriesCommon diagnosisPooled rateAdult admissionsCochrane LibraryDatabase inceptionDiagnostic error rateStudy characteristicsLiterature searchPatientsCommon diseaseDiagnosisCommon beingRate of Preventable Mortality in Hospitalized Patients: a Systematic Review and Meta-analysis
Rodwin BA, Bilan VP, Merchant NB, Steffens CG, Grimshaw AA, Bastian LA, Gunderson CG. Rate of Preventable Mortality in Hospitalized Patients: a Systematic Review and Meta-analysis. Journal Of General Internal Medicine 2020, 35: 2099-2106. PMID: 31965525, PMCID: PMC7351940, DOI: 10.1007/s11606-019-05592-5.Peer-Reviewed Original ResearchConceptsInpatient deathPreventable mortalityPreventable deathsMortality rateHospital mortality rateLife expectancyRandom-effects modelSystematic literature searchNumber of deathsWeb of ScienceHospital deathAdult patientsHospitalized patientsResultsSixteen studiesCase seriesPooled rateCochrane LibraryInclusion criteriaPatientsMeta-AnalysisSystematic reviewLiterature searchData extractionMortalityDeath