2023
Neurosteroid pathway derangement in asphyctic infants treated with hypothermia: an untargeted metabolomic approach
Valerio E, Stocchero M, Pirillo P, D’Errico I, Bonadies L, Galderisi A, Giordano G, Baraldi E. Neurosteroid pathway derangement in asphyctic infants treated with hypothermia: an untargeted metabolomic approach. EBioMedicine 2023, 92: 104636. PMID: 37257315, PMCID: PMC10244906, DOI: 10.1016/j.ebiom.2023.104636.Peer-Reviewed Original ResearchMeSH KeywordsAsphyxiaAsphyxia NeonatorumFemaleHumansHypothermiaHypoxia-Ischemia, BrainInfantInfant, NewbornLongitudinal StudiesMetabolomicsNeurosteroidsPregnancyConceptsAsphyctic infantsHypoxic-ischemic encephalopathyHealthy newbornsPerinatal asphyxiaMetabolic effectsSingle-center longitudinal studyDays of lifeTherapeutic hypothermiaUrinary metabolomePathobiological mechanismsSteroid levelsInfantsHypothermiaSteroidogenesis pathwayUntargeted metabolomics approachNewbornsSteroid contentTranslational researchLongitudinal studyPotential roleAsphyxiaEncephalopathyMetabolomics approachPathway analysisUntargeted metabolomics
2022
Lack of Evidence for a Causal Role of Hyperinsulinemia in the Progression of Obesity in Children and Adolescents: A Longitudinal Study.
Halloun R, Galderisi A, Caprio S, Weiss R. Lack of Evidence for a Causal Role of Hyperinsulinemia in the Progression of Obesity in Children and Adolescents: A Longitudinal Study. Diabetes Care 2022, 45: 1400-1407. PMID: 35235641, PMCID: PMC9210872, DOI: 10.2337/dc21-2210.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentBlood GlucoseBody Mass IndexChildFemaleHumansHyperinsulinismInsulinInsulin ResistanceLongitudinal StudiesMalePediatric ObesityConceptsDegree of obesityOral glucose tolerance testCarbohydrate-insulin modelLower postprandial glucosePostprandial glucoseInsulin secretionMultivariate analysisPostprandial glucose levelsPediatric obesity clinicProgression of obesityGlucose tolerance testCurve of insulinDevelopment of obesityGreater insulin secretionGreater increaseLack of evidenceInsulinogenic indexObesity clinicLower BMIObesity managementTolerance testGlucose levelsPeak insulinHyperinsulinemiaObesity
2020
Intrahepatic fat, irrespective of ethnicity, is associated with reduced endogenous insulin clearance and hepatic insulin resistance in obese youths: A cross‐sectional and longitudinal study from the Yale Pediatric NAFLD cohort
Tricò D, Galderisi A, Mari A, Polidori D, Galuppo B, Pierpont B, Samuels S, Santoro N, Caprio S. Intrahepatic fat, irrespective of ethnicity, is associated with reduced endogenous insulin clearance and hepatic insulin resistance in obese youths: A cross‐sectional and longitudinal study from the Yale Pediatric NAFLD cohort. Diabetes Obesity And Metabolism 2020, 22: 1628-1638. PMID: 32363679, PMCID: PMC8174801, DOI: 10.1111/dom.14076.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentChildCross-Sectional StudiesEthnicityHumansInsulinInsulin ResistanceLiverLongitudinal StudiesNon-alcoholic Fatty Liver DiseaseObesityConceptsHepatic insulin resistance indexNon-alcoholic fatty liver diseaseEndogenous insulin clearanceInsulin secretion rateInsulin clearanceHepatic insulin resistanceObese youthInsulin resistanceOral glucose tolerance testIntrahepatic fat accumulationIntrahepatic fat contentReduced insulin clearanceInsulin resistance indexFatty liver diseaseGlucose tolerance testWaist-hip ratioIntrahepatic lipid accumulationHepatic insulin sensitivityPlasma glucose levelsMulti-ethnic cohortC-peptide dataNAFLD cohortIntrahepatic fatLiver diseaseInsulin levelsMetabolic and Genetic Determinants of Glucose Shape After Oral Challenge in Obese Youths: A Longitudinal Study
Galderisi A, Tricò D, Man C, Santoro N, Pierpont B, Groop L, Cobelli C, Caprio S. Metabolic and Genetic Determinants of Glucose Shape After Oral Challenge in Obese Youths: A Longitudinal Study. The Journal Of Clinical Endocrinology & Metabolism 2020, 105: dgz207. PMID: 31972003, PMCID: PMC6977541, DOI: 10.1210/clinem/dgz207.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAllelesChildCross-Sectional StudiesDiabetes Mellitus, Type 2FemaleGenetic Predisposition to DiseaseGenotypeGlucoseGlucose IntoleranceGlucose Tolerance TestHumansInsulin SecretionInsulin-Secreting CellsLongitudinal StudiesMalePediatric ObesityPrediabetic StateTime FactorsTranscription Factor 7-Like 2 ProteinYoung AdultConceptsOral glucose tolerance testTCF7L2 rs7903146 variantΒ-cell responsivenessObese youthT risk alleleDisposition indexGlucose peakRs7903146 variantTCF7L2 rs7903146Lower disposition indexGlucose tolerance testOral minimal modelGlucose toleranceOral challengeDiabetes riskTolerance testInsulin sensitivityHigh glucose concentrationsLate peak groupMetabolic phenotypeGlucose concentrationLongitudinal studyReproducible markerPrevalenceRs7903146
2016
High frequency of diabetic ketoacidosis at diagnosis of type 1 diabetes in Italian children: a nationwide longitudinal study, 2004–2013
Cherubini V, Skrami E, Ferrito L, Zucchini S, Scaramuzza A, Bonfanti R, Buono P, Cardella F, Cauvin V, Chiari G, d′Annunzio G, Frongia A, Iafusco D, Patera I, Toni S, Tumini S, Rabbone I, Lombardo F, Carle F, Gesuita R, Lera R, De Luna L, Gualtieri A, Zecchino C, Piccinno E, Reinstadler P, Prandi E, Gallo F, Morganti G, Ripoli C, La Loggia A, Scanu P, Cardinale G, Tomaselli L, Citriniti F, Lazzaro N, De Donno V, Mainetti B, Coccioli M, Maccioni R, Marongiu U, Bruzzese M, Iannilli A, Pardi D, Confetto S, Zanfardino A, Iughetti L, Franzese A, Cadario F, Milia A, Piredda G, Soro M, Correddu A, Galderisi A, De Berardinis F, Federico G, Zanette G, Suprani T, Pedini A, Bitti M, Delvecchio M, Trada M, Meloni G, Gaiero A, Bulciolu P, Guerraggio L, Faleschini E, Zanatta M, Salvatoni A, Maffeis C, Arnaldi C. High frequency of diabetic ketoacidosis at diagnosis of type 1 diabetes in Italian children: a nationwide longitudinal study, 2004–2013. Scientific Reports 2016, 6: 38844. PMID: 27991500, PMCID: PMC5171855, DOI: 10.1038/srep38844.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAge FactorsDiabetes Mellitus, Type 1Diabetic KetoacidosisFemaleHumansItalyLongitudinal StudiesMaleConceptsSevere diabetic ketoacidosisDiabetic ketoacidosisType 1 diabetesDKA frequencyAge groupsLongitudinal population-based studyType 1 diabetes diagnosisMultiple logistic regression modelPopulation-based studyNationwide longitudinal studyYears of ageLogistic regression modelsItalian childrenFamily historyHigh riskMild/Diabetes diagnosisKetoacidosisHealthcare strategiesYoung age childrenDiabetesEarly detectionDiagnosisLongitudinal studyTime trends