2021
Could Sodium/Glucose Co-Transporter-2 Inhibitors Have Antiarrhythmic Potential in Atrial Fibrillation? Literature Review and Future Considerations
Vrachatis DA, Papathanasiou KA, Iliodromitis KE, Giotaki SG, Kossyvakis C, Raisakis K, Kaoukis A, Lambadiari V, Avramides D, Reimers B, Stefanini GG, Cleman M, Giannopoulos G, Lansky A, Deftereos SG. Could Sodium/Glucose Co-Transporter-2 Inhibitors Have Antiarrhythmic Potential in Atrial Fibrillation? Literature Review and Future Considerations. Drugs 2021, 81: 1381-1395. PMID: 34297330, DOI: 10.1007/s40265-021-01565-3.Peer-Reviewed Original ResearchConceptsAtrial fibrillationSGLT2 inhibitorsCardiorenal protectionAntiarrhythmic effectsClinical dataSodium/glucose co-transporter-2 inhibitorClinical data implyDate available evidenceGlucose-lowering medicationsEffective therapeutic optionPotential pathophysiological linkLarge clinical trialsPre-specified endpointsType 2 diabetesPossible beneficial effectsPost Hoc AnalysisNormoglycemic adultsAF burdenAF preventionPathophysiologic mechanismsPathophysiological linkSGLT2 inhibitionAntiarrhythmic potentialSodium glucoseTherapeutic options
2012
The Future REvascularization Evaluation in patients with Diabetes mellitus: Optimal management of Multivessel disease (FREEDOM) trial: Clinical and angiographic profile at study entry
Bansilal S, Farkouh ME, Hueb W, Ogdie M, Dangas G, Lansky AJ, Cohen DJ, Magnuson EA, Ramanathan K, Tanguay JF, Muratov V, Sleeper LA, Domanski M, Bertrand ME, Fuster V. The Future REvascularization Evaluation in patients with Diabetes mellitus: Optimal management of Multivessel disease (FREEDOM) trial: Clinical and angiographic profile at study entry. American Heart Journal 2012, 164: 591-599. PMID: 23067919, PMCID: PMC4536808, DOI: 10.1016/j.ahj.2012.06.012.Peer-Reviewed Original ResearchConceptsMultivessel coronary artery diseasePercutaneous coronary interventionDiabetic patientsFREEDOM trialBaseline characteristicsContemporary coronary artery bypassFuture Revascularization EvaluationMean hemoglobin A1cMean SYNTAX scoreMultivessel Disease (FREEDOM) trialOptimal medical therapyOptimal revascularization strategyCoronary artery bypassRisk factor controlMedian diabetes durationPrior myocardial infarctionSystolic blood pressureCoronary artery diseaseDrug-eluting stentsLow-density lipoproteinAngiographic profileVascular medicationsArtery bypassDiabetes durationSYNTAX score
2008
Clinical and angiographic outcomes in diabetic patients following single or multivessel stenting in the COSTAR II randomized trial.
Kereiakes DJ, Petersen JL, Batchelor WB, Fitzgerald PJ, Mehran R, Lansky A, Tsujino I, Schofer J, Dubois C, Verheye S, Cristea E, Garg J, Wijns W, Krucoff MW. Clinical and angiographic outcomes in diabetic patients following single or multivessel stenting in the COSTAR II randomized trial. Journal Of Invasive Cardiology 2008, 20: 335-41. PMID: 18599890.Peer-Reviewed Original ResearchMeSH KeywordsAngiographyAngioplasty, Balloon, CoronaryBlood GlucoseCoronary Artery DiseaseDiabetes Mellitus, Type 1Diabetes Mellitus, Type 2Drug-Eluting StentsFemaleFollow-Up StudiesGlycated HemoglobinHumansMaleMiddle AgedProspective StudiesRetrospective StudiesSingle-Blind MethodStentsTreatment OutcomeConceptsMajor adverse cardiovascular eventsPercutaneous coronary interventionDiabetic patientsAngiographic outcomesAdverse outcomesTaxus stentStent deploymentBare metal stent deploymentAdverse cardiovascular eventsMultivessel coronary diseaseTarget vessel revascularizationImproved clinical outcomesAngiographic restenosisCardiovascular eventsVessel revascularizationCoronary interventionCoronary diseaseGlycemic controlMultivessel stentingClinical outcomesDiabetic cohortElevated HbA1cLate lumenPatientsDiabetes
1998
Paradoxic Decreases in Atherosclerotic Plaque Mass in Insulin-Treated Diabetic Patients
Kornowski R, Mintz G, Lansky A, Hong M, Kent K, Pichard A, Satler L, Popma J, Bucher T, Leon M. Paradoxic Decreases in Atherosclerotic Plaque Mass in Insulin-Treated Diabetic Patients. The American Journal Of Cardiology 1998, 81: 1298-1304. PMID: 9631966, DOI: 10.1016/s0002-9149(98)00157-x.Peer-Reviewed Original ResearchConceptsArterial areaPlaque accumulationLumen compromiseDe novo native coronary stenosisInsulin-treated patientsInsulin-treated diabeticsNative coronary stenosisMultivariate linear regression analysisAtherosclerotic lesion formationBody surface areaParadoxic decreaseInsulin useDiabetes mellitusDiabetic patientsIndependent predictorsRemodeling indexAnginal syndromePlaque burdenCoronary stenosisArterial shrinkageInsulin treatmentPlaque massIntravascular ultrasoundLinear regression analysisReference segments