2006
Predictors of Recurrent In‐Stent Restenosis after Beta‐Radiation: An Analysis from the START 40/20 Trial
KANEDA H, HONDA Y, MORINO Y, LANSKY AJ, YOCK PG, BONAN R, FITZGERALD PJ. Predictors of Recurrent In‐Stent Restenosis after Beta‐Radiation: An Analysis from the START 40/20 Trial. Journal Of Interventional Cardiology 2006, 19: 376-380. PMID: 17020560, DOI: 10.1111/j.1540-8183.2006.00188.x.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAnalysis of VarianceAngioplasty, Balloon, CoronaryBeta ParticlesBlood Vessel Prosthesis ImplantationBrachytherapyCoronary AngiographyCoronary Artery BypassCoronary RestenosisFemaleFollow-Up StudiesHumansMaleMiddle AgedPredictive Value of TestsProspective StudiesRadiopharmaceuticalsRecurrenceStentsStrontium RadioisotopesTreatment OutcomeUltrasonography, InterventionalYttrium RadioisotopesConceptsTarget lesion revascularizationBalloon/artery ratioLesion revascularizationRecurrent ISRGeographic missArtery ratioStent restenosisPrimary catheter-based interventionMultivariate logistic regression analysisBeta-radiation therapyPredictors of recurrentRecurrence of stenosisTreatment of ISRLarge multicenter trialsMinimum lumen diameterCatheter-based interventionsPreliminary univariate analysisLogistic regression analysisIntravascular ultrasound parametersCohort patientsIndependent predictorsMulticenter trialDiameter stenosisUnivariate analysisBalloon sizingSafety of beta radiation exposure to the non-target segment: an intravascular ultrasound dosimetric analysis.
Kaneda H, Honda Y, Morino Y, Fox T, Crocker I, Lansky AJ, Yock PG, Bonan R, Fitzgerald PJ. Safety of beta radiation exposure to the non-target segment: an intravascular ultrasound dosimetric analysis. Journal Of Invasive Cardiology 2006, 18: 309-12. PMID: 16816435.Peer-Reviewed Original ResearchConceptsDosimetric analysisDistal segmentsRadiation exposureDistal reference sitesStent restenosis casesSignificant serial changesGreater radiation exposurePositive vessel remodelingRestenosis casesBeta radiation exposureLumen lossPositive remodelingCoronary arteryPlaque volumeGeographic missPlaque areaDistal vasculatureSerial changesPlaque massPlaque increasePrescribed doseVessel changesMild increaseMinimum doseVessel remodeling
2005
Angiographic and clinical outcomes at 8 months of cutting balloon angioplasty and β‐brachytherapy for native vessel in‐stent restenosis (BETACUT): Results from a stopped randomized controlled trial
Schlüter M, Tübler T, Lansky AJ, Kähler S, Berger J, Mathey DG, Schofer J. Angiographic and clinical outcomes at 8 months of cutting balloon angioplasty and β‐brachytherapy for native vessel in‐stent restenosis (BETACUT): Results from a stopped randomized controlled trial. Catheterization And Cardiovascular Interventions 2005, 66: 320-326. PMID: 16216024, DOI: 10.1002/ccd.20517.Peer-Reviewed Original ResearchConceptsStandard balloonClinical outcomesCB angioplastyBalloon angioplastyStent restenosisInterim analysisMajor adverse cardiac eventsNative vesselsAdverse cardiac eventsOverall patient populationImmediate angiographic outcomeTreatment of choiceQuantitative coronary angiographyΒ-brachytherapyAngiographic restenosisBeta-radiation treatmentLesion revascularizationAngiographic outcomesCardiac eventsConsecutive patientsCoronary angiographyStudy armsIntracoronary brachytherapyPatient populationTreatment modalitiesTwo-year clinical follow-up of 90Sr/90 Y β-radiation versus placebo control for the treatment of in-stent restenosis
Silber S, Popma JJ, Suntharalingam M, Lansky AJ, Heuser RR, Speiser B, Teirstein PS, Bass T, O'Neill W, Lasala J, Reisman M, Sharma SK, Kuntz RE, Bonan R, Investigators F. Two-year clinical follow-up of 90Sr/90 Y β-radiation versus placebo control for the treatment of in-stent restenosis. American Heart Journal 2005, 149: 689-694. PMID: 15990754, DOI: 10.1016/j.ahj.2004.05.061.Peer-Reviewed Original ResearchMeSH KeywordsAgedAngioplasty, Balloon, CoronaryAnticoagulantsBeta ParticlesBrachytherapyCoronary AngiographyCoronary DiseaseCoronary RestenosisDiabetes ComplicationsDisease-Free SurvivalFemaleFollow-Up StudiesHumansLife TablesMaleMiddle AgedPrognosisStentsStrontium RadioisotopesThrombophiliaTreatment OutcomeYttrium RadioisotopesConceptsMajor adverse cardiac eventsTarget vessel revascularizationStent restenosisIntracoronary brachytherapyOriginal patientsPrimary safety end pointTwo-year clinical outcomesPlacebo-controlled randomized trialEnd pointAdverse cardiac eventsPlacebo-controlled studyPrimary end pointSafety end pointKaplan-Meier analysisInitial beneficial effectsRestenosis TrialVessel revascularizationCardiac eventsPlacebo armClinical followActive treatmentClinical outcomesRandomized trialsPlacebo controlPatients
2003
Comparison of the angiographic outcomes after beta versus gamma vascular brachytherapy for treatment of in-stent restenosis
Shirai K, Lansky AJ, Mintz GS, Costantini CO, Fahy M, Mehran R, Dangas G, Moses JW, Stone GW, Waksman R, Leon MB. Comparison of the angiographic outcomes after beta versus gamma vascular brachytherapy for treatment of in-stent restenosis. The American Journal Of Cardiology 2003, 92: 1409-1413. PMID: 14675575, DOI: 10.1016/j.amjcard.2003.08.047.Peer-Reviewed Original ResearchConceptsMinimum lumen diameterVascular brachytherapyLesion lengthSegment restenosisAngiographic outcomesStent restenosisFinal minimum lumen diameterRandomized clinical trialsIndependent angiographic predictorsAngiographic restenosisPlacebo groupAngiographic predictorsAngiographic resultsMultivariable analysisNative coronariesVessel sizeClinical trialsLesion complexityVBT groupRestenosisLumen diameterSimilar reductionPlaceboGreater reductionLesionsBeta radiation in lesions > 15 mm: a START subgroup.
Heuser R, Laskey W, Lansky A, Popma J, Bonan R. Beta radiation in lesions > 15 mm: a START subgroup. Journal Of Invasive Cardiology 2003, 15: 641-3. PMID: 14608136.Peer-Reviewed Original ResearchConceptsPlacebo groupLong lesionsStent restenosisSTART trialMajor adverse cardiac eventsAngiographic lesion characteristicsIntracoronary beta radiationAdverse cardiac eventsBinary restenosis rateIncidence of recurrentMean lesion lengthSignificant reductionLesion revascularizationRecurrent restenosisVessel revascularizationAngiographic parametersCardiac eventsClinical restenosisPatient demographicsRestenosis rateCoronary lesionsStent thrombosisLesion characteristicsRadiation groupRadiation therapyVascular brachytherapy using a beta emitter source in diabetic patients with in-stent restenosis: Angiographic and clinical outcomes
Suntharalingam M, Laskey WK, Tantibhedhyangkul W, Lansky A, Teirstein P, Bass T, Silber S, Rutherford B, Wilmer C, Popma JJ, Kuntz R, Bonan R. Vascular brachytherapy using a beta emitter source in diabetic patients with in-stent restenosis: Angiographic and clinical outcomes. International Journal Of Radiation Oncology • Biology • Physics 2003, 57: 536-542. PMID: 12957267, DOI: 10.1016/s0360-3016(03)00537-6.Peer-Reviewed Original ResearchConceptsVessel revascularization ratePercutaneous coronary interventionDiabetic patientsNondiabetic patientsVascular brachytherapyNondiabetic counterpartsStent restenosisRevascularization ratesCoronary interventionLess target lesion revascularizationConventional percutaneous coronary interventionBinary angiographic restenosisAngiographic restenosis rateTarget lesion revascularizationReference vessel diameterComplex coronary lesionsMinimal lumen diameterStudy of patientsPercent diameter stenosisVessel diameterTreatment effectsBeta-Cath SystemBreslow-Day testLesion revascularizationAngiographic restenosisUsefulness of beta radiation for de novo and In-Stent restenotic lesions in saphenous vein grafts
Stone GW, Mehran R, Midei M, Waksman R, Schaer GL, Negoita M, Lansky AJ, Buchbinder M, Investigators S. Usefulness of beta radiation for de novo and In-Stent restenotic lesions in saphenous vein grafts. The American Journal Of Cardiology 2003, 92: 312-314. PMID: 12888142, DOI: 10.1016/s0002-9149(03)00635-0.Peer-Reviewed Original ResearchIntravascular brachytherapy for native coronary ostial in-stent restenotic lesions
Costantini CO, Lansky AJ, Mintz GS, Shirai K, Dangas G, Mehran R, Fahy M, Slack S, Coral M, Teirstein PS, Waksman R, Stone G, Moses J, Leon MB. Intravascular brachytherapy for native coronary ostial in-stent restenotic lesions. Journal Of The American College Of Cardiology 2003, 41: 1725-1731. PMID: 12767655, DOI: 10.1016/s0735-1097(03)00298-5.Peer-Reviewed Original ResearchConceptsAorto-ostial lesionsVascular brachytherapyRecurrence rateOstial ISRRestenosis rateStent restenosisBaseline lesion lengthStent restenotic lesionsHigh recurrence rateBinary restenosisPercutaneous reinterventionPlacebo patientsISR lesionsRestenotic lesionsQuantitative angiographyBeta patientsPatientsPooled databaseConventional treatmentRestenosisPlaceboLesionsLesion lengthBrachytherapySimilar reductionImplications of the presence and length of “geographic miss” on restenosis and the edge phenomenon in the INHIBIT trial
Costantini CO, Lansky AJ, Mintz GS, Shirai K, Teirstein PS, Stone G, Vandertie L, Proctor B, Fahy M, Yeung A, Raizner AE, Waksman R, Leon MB. Implications of the presence and length of “geographic miss” on restenosis and the edge phenomenon in the INHIBIT trial. The American Journal Of Cardiology 2003, 91: 1261-1265. PMID: 12745117, DOI: 10.1016/s0002-9149(03)00280-7.Peer-Reviewed Original Research
2002
Delivered Dose and Vascular Response After β-Radiation for In-Stent Restenosis
Morino Y, Kaneda H, Fox T, Takagi A, Hassan AH, Bonan R, Crocker I, Lansky AJ, Laskey WK, Suntharalingam M, Bonneau HN, Yock PG, Honda Y, Fitzgerald PJ. Delivered Dose and Vascular Response After β-Radiation for In-Stent Restenosis. Circulation 2002, 106: 2334-2339. PMID: 12403663, DOI: 10.1161/01.cir.0000036367.17043.03.Peer-Reviewed Original ResearchMeSH KeywordsBeta ParticlesBlood Vessel Prosthesis ImplantationBrachytherapyCohort StudiesCoronary AngiographyCoronary Artery DiseaseCoronary RestenosisCoronary VesselsDose-Response Relationship, RadiationFemaleHumansLinear ModelsMaleMiddle AgedRadiation DosageRadiometryRetrospective StudiesStentsTreatment OutcomeUltrasonography, InterventionalVascular PatencyConceptsIntimal hyperplasia volumeDose intensityVolumetric intravascular ultrasound analysisDose-dependent complicationsRadiation therapy trialsSerial Volumetric Intravascular Ultrasound AnalysisStent restenosis casesStent restenosis lesionsIn-Stent RestenosisIntravascular ultrasound analysisPrescribed radiation doseSource trainRestenosis casesRestenosis lesionsVascular changesVascular responsesTherapy trialsDose prescriptionLong subsegmentsDevice injuryUltrasound analysisStent segmentDoseDose rangeIVUS catheterRandomized Trial of 90Sr/90Y β-Radiation Versus Placebo Control for Treatment of In-Stent Restenosis
Popma JJ, Suntharalingam M, Lansky AJ, Heuser RR, Speiser B, Teirstein PS, Massullo V, Bass T, Henderson R, Silber S, von Rottkay P, Bonan R, Ho KK, Osattin, MPH A, Kuntz RE. Randomized Trial of 90Sr/90Y β-Radiation Versus Placebo Control for Treatment of In-Stent Restenosis. Circulation 2002, 106: 1090-1096. PMID: 12196334, DOI: 10.1161/01.cir.0000027814.96651.72.Peer-Reviewed Original ResearchConceptsTarget vessel revascularizationStent restenosisPlacebo-treated patientsPrimary end pointCatheter-based treatmentIn-Stent RestenosisPlacebo sourcesStent thrombosesAngiographic restenosisClinical restenosisFirst multicenterIntracoronary radiationMyocardial infarctionPlacebo controlPatientsPrescribed doseRestenosisConventional treatmentIntracoronary catheterEnd pointDay 244PlaceboRevascularizationTreatmentIncidence
2000
Intracoronary β-Radiation Therapy Inhibits Recurrence of In-Stent Restenosis
Waksman R, Bhargava B, White L, Chan R, Mehran R, Lansky A, Mintz G, Satler L, Pichard A, Leon M, Kent K. Intracoronary β-Radiation Therapy Inhibits Recurrence of In-Stent Restenosis. Circulation 2000, 101: 1895-1898. PMID: 10779453, DOI: 10.1161/01.cir.101.16.1895.Peer-Reviewed Original ResearchConceptsRevascularization ratesBinary angiographic restenosis rateIntracoronary gamma radiation therapyTarget vessel revascularization rateTarget lesion revascularization ratePercutaneous transluminal coronary angioplastyVessel revascularization rateAngiographic restenosis rateLesion revascularization rateTransluminal coronary angioplastyIn-Stent RestenosisGamma radiation therapyRecurrent ISRPlacebo groupClinical restenosisAdjunct therapyConsecutive patientsCoronary angioplastyRestenosis rateRotational atherectomyStent implantationBalloon catheterNative coronariesStent restenosisPatientsSerial volumetric intravascular ultrasound analysis of the efficacy of beta irradiation in preventing recurrent in-stent restenosis
Bhargava B, Mintz G, Mehran R, Lansky A, Weissman N, Walsh C, Chan R, Waksman R. Serial volumetric intravascular ultrasound analysis of the efficacy of beta irradiation in preventing recurrent in-stent restenosis. The American Journal Of Cardiology 2000, 85: 651-653. PMID: 11078283, DOI: 10.1016/s0002-9149(99)00827-9.Peer-Reviewed Original ResearchConceptsRestenosis TrialWashington RadiationVolumetric intravascular ultrasound analysisIntimal hyperplasia volumeSerial Volumetric Intravascular Ultrasound AnalysisIntravascular ultrasound findingsIntravascular ultrasound analysisUltrasound findingsStent restenosisPlaceboUltrasound analysisLumen volumePatientsTrialsBetaGammaBeta irradiationRestenosisPostinterventionRecurrent