2010
Multicenter validation of the diagnostic accuracy of a blood-based gene expression test for assessing obstructive coronary artery disease in nondiabetic patients.
Rosenberg S, Elashoff MR, Beineke P, Daniels SE, Wingrove JA, Tingley WG, Sager PT, Sehnert AJ, Yau M, Kraus WE, Newby LK, Schwartz RS, Voros S, Ellis SG, Tahirkheli N, Waksman R, McPherson J, Lansky A, Winn ME, Schork NJ, Topol EJ. Multicenter validation of the diagnostic accuracy of a blood-based gene expression test for assessing obstructive coronary artery disease in nondiabetic patients. Annals Of Internal Medicine 2010, 153: 425-34. PMID: 20921541, PMCID: PMC3786733, DOI: 10.7326/0003-4819-153-7-201010050-00005.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsAgedAged, 80 and overAlgorithmsArea Under CurveChest PainCoronary AngiographyCoronary Artery DiseaseDiabetes MellitusFemaleGene ExpressionHumansMaleMiddle AgedProspective StudiesReverse Transcriptase Polymerase Chain ReactionRisk AssessmentROC CurveSensitivity and SpecificitySex FactorsYoung AdultConceptsObstructive coronary artery diseaseCoronary artery diseaseCoronary angiographyNondiabetic patientsQuantitative coronary angiographyArtery diseasePresence of CADClinical modelMore major coronary arteriesPeripheral blood gene expressionBlood-based gene expression testDiamond-Forrester methodMulticenter prospective trialMajor coronary arteriesChronic inflammatory disordersIndependent validation cohortReceiver-operating characteristic analysisBlood gene expressionReal-time polymerase chain reactionWhole blood testCardiac protein markersGene expression testNoninvasive imaging methodProspective trialRisk patientsIntravascular Ultrasound Classification of Plaque Distribution in Left Main Coronary Artery Bifurcations
Oviedo C, Maehara A, Mintz GS, Araki H, Choi SY, Tsujita K, Kubo T, Doi H, Templin B, Lansky AJ, Dangas G, Leon MB, Mehran R, Tahk SJ, Stone GW, Ochiai M, Moses JW. Intravascular Ultrasound Classification of Plaque Distribution in Left Main Coronary Artery Bifurcations. Circulation Cardiovascular Interventions 2010, 3: 105-112. PMID: 20197513, DOI: 10.1161/circinterventions.109.906016.Peer-Reviewed Original ResearchMeSH KeywordsAgedCoronary AngiographyCoronary StenosisHumansMaleMiddle AgedReproducibility of ResultsRetrospective StudiesSensitivity and SpecificityUltrasonography, InterventionalConceptsLCX arteryMain coronary artery bifurcationLeft main coronary artery bifurcationIntravascular ultrasoundPlaque distributionCoronary artery bifurcationsAngiographic classificationArtery bifurcationLAD arteryBifurcation lesionsDistal LMCACircumflex artery lesionsLMCA bifurcation lesionsPreintervention intravascular ultrasoundProximal LAD arteryAngiographic diameter stenosisSeverity of diseaseIVUS plaque burdenLMCA lengthArtery lesionsAnterior descendingPlaque burdenDiameter stenosisBifurcation diseaseLCX ostium
2007
An evaluation of fluoroscopy time and correlation with outcomes after percutaneous coronary intervention.
Nikolsky E, Pucelikova T, Mehran R, Balter S, Kaufman L, Fahy M, Lansky AJ, Leon MB, Moses JW, Stone GW, Dangas G. An evaluation of fluoroscopy time and correlation with outcomes after percutaneous coronary intervention. Journal Of Invasive Cardiology 2007, 19: 208-13. PMID: 17476034.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAgedAngioplasty, Balloon, CoronaryCohort StudiesCoronary AngiographyCoronary Artery BypassCoronary DiseaseElectrocardiographyFemaleFluoroscopyFollow-Up StudiesHospital MortalityHumansLinear ModelsMaleMiddle AgedMultivariate AnalysisPredictive Value of TestsProbabilityRetrospective StudiesRisk FactorsSensitivity and SpecificitySeverity of Illness IndexSurvival RateTime FactorsTreatment OutcomeConceptsCoronary artery bypass surgeryPercutaneous coronary interventionEmergent coronary artery bypass surgeryPrior coronary artery bypass surgeryProlonged fluoroscopy timeContrast-induced nephropathyPeripheral arterial diseaseFluoroscopy timeBaseline TIMICoronary interventionArterial diseaseComplexity of PCIType B2/C lesionsB2/C lesionsSevere lesion calcificationChronic renal insufficiencyArtery bypass surgeryShort-term prognosisMean fluoroscopy timeHospital deathHospital outcomesPeriprocedural complicationsRenal insufficiencyBypass surgeryLesion calcification
2004
Myocardial First-Pass Perfusion Magnetic Resonance Imaging
Wolff SD, Schwitter J, Coulden R, Friedrich MG, Bluemke DA, Biederman RW, Martin ET, Lansky AJ, Kashanian F, Foo TK, Licato PE, Comeau CR. Myocardial First-Pass Perfusion Magnetic Resonance Imaging. Circulation 2004, 110: 732-737. PMID: 15289374, DOI: 10.1161/01.cir.0000138106.84335.62.Peer-Reviewed Original ResearchMeSH KeywordsAdenosineAgedArea Under CurveCardiac CatheterizationContrast MediaCoronary AngiographyCoronary CirculationCoronary DiseaseDose-Response Relationship, DrugFalse Positive ReactionsFemaleGadolinium DTPAHumansHyperemiaMagnetic Resonance ImagingMaleMiddle AgedMyocardiumProspective StudiesROC CurveSensitivity and SpecificitySingle-Blind MethodConceptsObstructive coronary artery diseaseCoronary artery diseaseArtery diseaseFirst-pass perfusion magnetic resonance imagingReceiver-operating curve analysisHigher contrast dosesDose-ranging studyCoronary artery catheterizationLow-dose groupPerfusion magnetic resonance imagingQuantitative coronary angiographyFirst-pass perfusion imagingLeft ventricular myocardiumReceiver-operating curveMagnetic resonance imagingFirst-pass perfusion MRIGadopentetate dimeglumine injectionCoronary angiographyArtery catheterizationEfficacious doseClinical evaluationContrast doseMyocardial hyperemiaPerfusion defectsGadopentate dimeglumine
2002
Quantitative angiographic methods for appropriate end-point analysis, edge-effect evaluation, and prediction of recurrent restenosis after coronary brachytherapy with gamma irradiation
Lansky AJ, Dangas G, Mehran R, Desai KJ, Stone G, Leon M, Mintz G, Waksman R, Wu H, Fahy M. Quantitative angiographic methods for appropriate end-point analysis, edge-effect evaluation, and prediction of recurrent restenosis after coronary brachytherapy with gamma irradiation. Journal Of The American College Of Cardiology 2002, 39: 274-280. PMID: 11788219, DOI: 10.1016/s0735-1097(01)01745-4.Peer-Reviewed Original ResearchMeSH KeywordsBrachytherapyCoronary AngiographyCoronary RestenosisHumansIridium RadioisotopesLogistic ModelsRandomized Controlled Trials as TopicRecurrenceROC CurveSensitivity and SpecificityConceptsTarget vessel revascularizationRecurrent restenosisDiameter stenosisReceiver operator curveStent restenosisIn-Stent Restenosis TrialIntracoronary radiation therapyPercent diameter stenosisQuantitative coronary angiographyQuantitative angiographic methodsAngiographic locationBlinded therapyRestenosis TrialVessel revascularizationClinical restenosisCoronary angiographyRestenosis rateRestenotic lesionsTreatment failureWashington RadiationBrachytherapy trialsInterventional treatmentVascular brachytherapyEnd-point analysisRadiation therapy