2024
Outcomes for Mechanically Ventilated Patients With Acute Myocardial Infarction Admitted to Medical vs Cardiac Intensive Care Units
Shahu A, Namburar S, Banna S, Harris A, Schenck C, Trejo-Paredes C, Thomas A, Ali T, Carnicelli A, Barnett C, Solomon M, Miller P. Outcomes for Mechanically Ventilated Patients With Acute Myocardial Infarction Admitted to Medical vs Cardiac Intensive Care Units. JACC Advances 2024, 3: 101199. PMID: 39238851, PMCID: PMC11375252, DOI: 10.1016/j.jacadv.2024.101199.Peer-Reviewed Original ResearchAcute myocardial infarctionAssociated with lower in-hospital mortalityIn-hospital mortalityLower in-hospital mortalityIntensive care unitMedical ICUPrimary diagnosis of acute myocardial infarctionMultivariable adjustmentCICU admissionInvasive mechanical ventilationVizient Clinical Data BaseBackground Acute myocardial infarctionDiagnosis of acute myocardial infarctionMultivariate logistic regressionMedical intensive care unitClinical outcomesMechanical ventilationCardiogenic shockClinical Data BaseMyocardial infarctionHospital sizeTriage of critically ill patientsMedian ventilator daysTeaching hospitalLogistic regressionTracheostomy in Patients with Acute Myocardial Infarction and Respiratory Failure
Grammatico M, Banna S, Shahu A, Gastanadui M, Jimenez J, Heck C, Arias-Olson A, Thomas A, Ali T, Miller P. Tracheostomy in Patients with Acute Myocardial Infarction and Respiratory Failure. Journal Of Intensive Care Medicine 2024, 39: 1131-1137. PMID: 38715423, DOI: 10.1177/08850666241253202.Peer-Reviewed Original ResearchDays of tracheostomyInvasive mechanical ventilationIn-hospital mortalityAcute myocardial infarctionTiming of tracheostomyRespiratory failureAntiplatelet regimensMyocardial infarctionAssociated with lower in-hospital mortalityIncidence of tracheostomyLower in-hospital mortalityProportion of patientsIncidence of patientsDiagnosis of acute myocardial infarctionDAPT interruptionTracheostomy complicationsBlood transfusionOpen tracheostomyAntiplatelet therapyMechanical ventilationMultivariable adjustmentDAPT usePrimary diagnosis of acute myocardial infarctionClinical Data BaseTracheostomyPropofol vs etomidate for induction prior to invasive mechanical ventilation in patients with acute myocardial infarction
Thomas A, Banna S, Shahu A, Ali T, Schenck C, Patel B, Notarianni A, Phommalinh M, Kochar A, Heck C, van Diepen S, Miller P. Propofol vs etomidate for induction prior to invasive mechanical ventilation in patients with acute myocardial infarction. American Heart Journal 2024, 272: 116-125. PMID: 38554762, DOI: 10.1016/j.ahj.2024.03.013.Peer-Reviewed Original ResearchConceptsAssociated with lower mortalityAcute myocardial infarctionInvasive mechanical ventilationLower mortalityUS national databaseClinical Data BaseMyocardial infarctionIll patient populationLength of stayCritically ill patient populationIn-hospital mortalityInverse probability treatmentOptimal induction agentInduction agentNational databaseClinical outcomesMechanical ventilationProbability treatmentPropensity weightingPatient populationRandomized trialsMortalityUtilization of propofolVentilator daysPropofol group
2023
Stress Ulcer Prophylaxis in Mechanically Ventilated Patients With Acute Myocardial Infarction
Banna S, Schenck C, Shahu A, Thomas A, Heck C, Tangredi R, Ali T, Miller P. Stress Ulcer Prophylaxis in Mechanically Ventilated Patients With Acute Myocardial Infarction. JACC Advances 2023, 3: 100750. PMID: 38939822, PMCID: PMC11198220, DOI: 10.1016/j.jacadv.2023.100750.Peer-Reviewed Original ResearchInvasive mechanical ventilationProton pump inhibitorsStress ulcer prophylaxisAcute myocardial infarctionUlcer prophylaxisVentilator-associated pneumoniaMyocardial infarctionVentilator daysST-segment elevation myocardial infarctionBackground Proton pump inhibitorsLess ventilator-associated pneumoniaVizient Clinical Data BaseObservation cohort studyProportion of patientsElevation myocardial infarctionMultivariable logistic regressionClostridium difficile infectionLower hospitalization costsClinical data baseCardiogenic shockHospital mortalityCohort studyMultivariate adjustmentHospitalization costsMechanical ventilationEarly Clinical Outcomes of Patients With Stress-Induced Cardiomyopathy Receiving Acute Mechanical Support in the US
Jang S, Webber F, Alam M, Bae J, Aggarwal A, Thomas A, Zarich S, Ahmad T, Miller P, Davila C. Early Clinical Outcomes of Patients With Stress-Induced Cardiomyopathy Receiving Acute Mechanical Support in the US. Journal Of The Society For Cardiovascular Angiography & Interventions 2023, 2: 101185. PMID: 39131072, PMCID: PMC11308019, DOI: 10.1016/j.jscai.2023.101185.Peer-Reviewed Original ResearchAcute mechanical circulatory supportStress-induced cardiomyopathyRenal replacement therapyCardiogenic shockIndex hospitalizationReplacement therapyIntra-aortic balloon pumpAggressive hemodynamic supportHospital mortality rateNationwide Readmissions DatabaseMechanical circulatory supportFuture prospective studiesLarge national databaseObserved mortality differencesHospital mortalityMore comorbiditiesHospital deathHemodynamic supportBalloon pumpMembrane oxygenationClinical outcomesCirculatory supportProspective studyAdministrative databasesImpellaAntiplatelet Strategies Following PCI: A Review of Trials Informing Current and Future Therapies
Thomas A, Gitto M, Shah S, Saito Y, Tirziu D, Chieffo A, Stefanini G, Lansky A. Antiplatelet Strategies Following PCI: A Review of Trials Informing Current and Future Therapies. Journal Of The Society For Cardiovascular Angiography & Interventions 2023, 2: 100607. PMID: 39130709, PMCID: PMC11307978, DOI: 10.1016/j.jscai.2023.100607.Peer-Reviewed Original ResearchDual antiplatelet therapyAntiplatelet regimensPatient-specific risk profileShorter DAPT durationDuration of therapyPercutaneous coronary interventionDAPT strategyIschemic riskAntiplatelet therapyDAPT durationAntiplatelet strategiesCoronary interventionOngoing trialsMajor trialsRecent trialsPractice guidelinesFuture therapiesRisk profileTherapyStent technologyTrialsRegimensNumber of trialsSignificant reductionSignificant changes
2022
Oxygen Supplementation and Hyperoxia in Critically Ill Cardiac Patients From Pathophysiology to Clinical Practice
Thomas A, van Diepen S, Beekman R, Sinha SS, Brusca SB, Alviar CL, Jentzer J, Bohula EA, Katz JN, Shahu A, Barnett C, Morrow DA, Gilmore EJ, Solomon MA, Miller PE. Oxygen Supplementation and Hyperoxia in Critically Ill Cardiac Patients From Pathophysiology to Clinical Practice. JACC Advances 2022, 1: 100065. PMID: 36238193, PMCID: PMC9555075, DOI: 10.1016/j.jacadv.2022.100065.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsOxygen supplementationIntensive care unit cliniciansHarmful hemodynamic effectsAdverse clinical outcomesIll cardiac patientsManagement of patientsAcute cardiac diseaseAcute myocardial infarctionDirect cellular toxicityCoronary vasoconstrictionPulmonary hypertensionRespiratory failureHemodynamic effectsHeart failureOxygen therapyClinical outcomesSupplemental oxygenAvailable trialsCardiac arrestMyocardial infarctionCardiac patientsCardiac diseaseClinical practiceCardiovascular systemHyperoxiaStaffing models in the cardiac intensive care unit
Quien M, Thomas A, Ludmir J, Miller PE. Staffing models in the cardiac intensive care unit. Current Opinion In Critical Care 2022, 28: 453-459. PMID: 35757936, DOI: 10.1097/mcc.0000000000000958.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsCardiac intensive care unitIntensive care unitCare unitContemporary cardiac intensive care unitsModern cardiac intensive care unitMechanical circulatory supportSick patient populationFuture multicenter studiesStaffing modelsPreponderance of dataShock teamRespiratory failureIll patientsCirculatory supportMulticenter studyCardiac arrestPatient populationCardiac intensivistsIll populationMortalityRecent evidenceIntensivistsPatientsRecent dataPopulationRelation of Ischemic Heart Disease to Outcomes in Patients With Acute Respiratory Distress Syndrome
Biondi M, Jain S, Fuery M, Thomas A, Ali T, Alviar CL, Desai NR, Miller PE. Relation of Ischemic Heart Disease to Outcomes in Patients With Acute Respiratory Distress Syndrome. The American Journal Of Cardiology 2022, 176: 24-29. PMID: 35606175, DOI: 10.1016/j.amjcard.2022.04.034.Peer-Reviewed Original ResearchConceptsIschemic heart diseaseVentilator-free daysHeart diseaseHistory of IHDImpact of IHDAcute respiratory distress syndromePredictors of mortalityRespiratory distress syndromeSeverity of illnessMultivariable logistic regressionMultivariable adjustmentSecondary outcomesDistress syndromeOrgan failurePrimary outcomeClinical outcomesIll subgroupStudy criteriaTreatment paradigmClinical trialsARDS severityPatientsHigh mortalityEnd pointMortalitySafety and Efficacy of the Supreme Biodegradable Polymer Sirolimus-Eluting Stent in Patients With Diabetes Mellitus
Thomas A, Kereiakes D, Baumbach A, Windecker S, Pietras C, Dressler O, Issever M, Curtis M, Bertolet B, Zidar J, Smits P, Díaz V, McLaurin B, Cequier Á, Takahashi A, Cannon L, Amoroso G, Kakuta T, Saito S, Leon M, Lansky A. Safety and Efficacy of the Supreme Biodegradable Polymer Sirolimus-Eluting Stent in Patients With Diabetes Mellitus. Journal Of The Society For Cardiovascular Angiography & Interventions 2022, 1: 100033. PMID: 39132558, PMCID: PMC11307809, DOI: 10.1016/j.jscai.2022.100033.Peer-Reviewed Original ResearchTarget vessel myocardial infarctionVessel myocardial infarctionDiabetes mellitusDP-EESLesion failureIII trialsCardiac deathMyocardial infarctionBiodegradable Polymer Sirolimus-Eluting StentBiodegradable polymer sirolimus-eluting stentsTarget lesion failureTarget lesion revascularizationPercutaneous coronary interventionSirolimus-Eluting StentsLong-term inflammatory responseDiabetic subgroupsLesion revascularizationNondiabetic patientsSecondary endpointsBackground PatientsCoronary interventionPrespecified analysisComposite endpointPrimary safetyWorse outcomes
2021
TCT-290 Safety and Efficacy of the Supreme Biodegradable Polymer Sirolimus-Eluting Stent in Patients With Diabetes Mellitus: Results From the PIONEER III Clinical Trial
Thomas A, Kereiakes D, Leon M, Baumbach A, Windecker S, Pietras C, Dressler O, Issever M, Curtis M, Bertolet B, Zidar J, Smits P, Diaz V, Mclaurin B, Cequier A, Takahashi A, Amoroso G, Kakuta T, Carney R, Saito S, Lansky A. TCT-290 Safety and Efficacy of the Supreme Biodegradable Polymer Sirolimus-Eluting Stent in Patients With Diabetes Mellitus: Results From the PIONEER III Clinical Trial. Journal Of The American College Of Cardiology 2021, 78: b119. DOI: 10.1016/j.jacc.2021.09.1143.Peer-Reviewed Original ResearchMyopericarditis with Significant Left Ventricular Dysfunction Following COVID-19 Vaccination: A Case Report
Bartlett VL, Thomas A, Hur DJ, Malm B. Myopericarditis with Significant Left Ventricular Dysfunction Following COVID-19 Vaccination: A Case Report. American Journal Of Case Reports 2021, 22: e934066-1-e934066-6. PMID: 34795198, PMCID: PMC8611472, DOI: 10.12659/ajcr.934066.Peer-Reviewed Case Reports and Technical NotesConceptsSignificant left ventricular dysfunctionLeft ventricular dysfunctionCOVID-19 vaccinationVentricular dysfunctionCOVID-19 vaccineCase reportNon-steroidal anti-inflammatory treatmentBNT162b2 COVID-19 vaccineAdverse effectsGreater cardiac dysfunctionAnti-inflammatory treatmentRare adverse effectMiddle-aged patientsSafety of vaccinesMiddle-aged menEmergency use authorizationMyopericarditis casesAdverse eventsVentricular functionCardiac dysfunctionSecond doseVaccinationMyopericarditisDysfunctionVaccineForgone Medical Care Associated With Increased Health Care Costs Among the U.S. Heart Failure Population
Thomas A, Valero-Elizondo J, Khera R, Warraich HJ, Reinhardt SW, Ali HJ, Nasir K, Desai NR. Forgone Medical Care Associated With Increased Health Care Costs Among the U.S. Heart Failure Population. JACC Heart Failure 2021, 9: 710-719. PMID: 34391737, DOI: 10.1016/j.jchf.2021.05.010.Peer-Reviewed Original ResearchConceptsHeart failureHealth care utilizationHealth care costsHealth care expendituresCare utilizationCare costsMedical careMore emergency department visitsTotal health care costsCare expendituresAnnual health careAnnual inpatient costsPrevalence of patientsEmergency department visitsMedical Expenditure Panel SurveyOverall health care spendingHF patientsElderly patientsCare AssociatedDepartment visitsFailure populationInpatient costsHealth care spendingLeading causePatientsElectronic health record risk score provides earlier prognostication of clinical outcomes in patients admitted to the cardiac intensive care unit
Kunitomo Y, Thomas A, Chouairi F, Canavan ME, Kochar A, Khera R, Katz JN, Murphy C, Jentzer J, Ahmad T, Desai NR, Brennan J, Miller PE. Electronic health record risk score provides earlier prognostication of clinical outcomes in patients admitted to the cardiac intensive care unit. American Heart Journal 2021, 238: 85-88. PMID: 33891906, DOI: 10.1016/j.ahj.2021.04.004.Peer-Reviewed Original ResearchConceptsCardiac intensive care unitIntensive care unitRothman IndexCare unitRisk scoreModern cardiac intensive care unitSequential Organ Failure Assessment scoreOrgan Failure Assessment scoreElectronic health recordsCICU mortalityCICU patientsSOFA scoreCICU admissionClinical outcomesEarly prognosticationObservational studyPrognostic abilityAssessment scoresOutcome predictionHealth recordsGood calibrationSuperior discriminationPatientsAdmissionScoresTransition From an Open to Closed Staffing Model in the Cardiac Intensive Care Unit Improves Clinical Outcomes
Miller PE, Chouairi F, Thomas A, Kunitomo Y, Aslam F, Canavan ME, Murphy C, Daggula K, Metkus T, Vallabhajosyula S, Carnicelli A, Katz JN, Desai NR, Ahmad T, Velazquez EJ, Brennan J. Transition From an Open to Closed Staffing Model in the Cardiac Intensive Care Unit Improves Clinical Outcomes. Journal Of The American Heart Association 2021, 10: e018182. PMID: 33412899, PMCID: PMC7955420, DOI: 10.1161/jaha.120.018182.Peer-Reviewed Original ResearchConceptsCardiac intensive care unitIntensive care unitHospital mortalityCare unitCICU mortalityClinical outcomesModern cardiac intensive care unitSurgical intensive care unitTotal hospital chargesSeverity of illnessMultivariable logistic regressionCICU lengthMultivariable adjustmentRespiratory insufficiencyPrimary outcomeUnique admissionsHospital chargesCardiac arrestSubgroup analysisImproved outcomesMortalityLogistic regressionAdmissionClosed unitStaffing models
2020
Prevalence of Noncardiac Multimorbidity in Patients Admitted to Two Cardiac Intensive Care Units and Their Association with Mortality
Miller PE, Thomas A, Breen TJ, Chouairi F, Kunitomo Y, Aslam F, Damluji AA, Anavekar NS, Murphy JG, van Diepen S, Barsness GW, Brennan J, Jentzer J. Prevalence of Noncardiac Multimorbidity in Patients Admitted to Two Cardiac Intensive Care Units and Their Association with Mortality. The American Journal Of Medicine 2020, 134: 653-661.e5. PMID: 33129785, PMCID: PMC8079541, DOI: 10.1016/j.amjmed.2020.09.035.Peer-Reviewed Original ResearchConceptsCritical care therapiesNoncardiac comorbiditiesCICU populationCare therapyLong-term adverse clinical outcomesCardiac intensive care unitIntensive care unit practiceBetter care pathwaysIncreased hospital mortalityNoncardiac organ failureUnique patient admissionsAdverse clinical outcomesIntensive care unitMultivariable logistic regressionLength of stayAcute cardiac illnessCICU patientsHospital mortalityNoncardiac indicationsICU admissionMultivariable adjustmentOrgan failureCare unitClinical outcomesCardiac illnessUse and outcomes of wearable cardioverter-defibrillators in a large integrated academic health system
Kahn PA, Gruen J, Thomas A, Ahmad T, Desai NR. Use and outcomes of wearable cardioverter-defibrillators in a large integrated academic health system. American Heart Journal 2020, 226: 232-234. PMID: 32811638, DOI: 10.1016/j.ahj.2020.04.007.Peer-Reviewed Original ResearchA Confusing Picture: Refractory Encephalopathy Complicating Nonalcoholic Steatohepatitis
Kravetz JD, Varma P, Hosseini R, Thomas A, Eder MD. A Confusing Picture: Refractory Encephalopathy Complicating Nonalcoholic Steatohepatitis. The American Journal Of Medicine 2020, 133: e546-e548. PMID: 32087105, DOI: 10.1016/j.amjmed.2020.01.026.Peer-Reviewed Case Reports and Technical NotesAgedBrainConfusionDyskinesiasEsophageal and Gastric VaricesGastrointestinal AgentsHepatic EncephalopathyHumansHyperammonemiaHyperbilirubinemiaHypertension, PortalLactuloseLiver CirrhosisMagnetic Resonance ImagingMaleNon-alcoholic Fatty Liver DiseaseRenal VeinsRifaximinSplenic VeinThrombocytopeniaTomography, X-Ray ComputedTremorVascular DiseasesAccess and Outcomes Among Hypertrophic Cardiomyopathy Patients in a Large Integrated Health System
Thomas A, Papoutsidakis N, Spatz E, Testani J, Soucier R, Chou J, Ahmad T, Darr U, Hu X, Li F, Chen ME, Bellumkonda L, Sumathipala A, Jacoby D. Access and Outcomes Among Hypertrophic Cardiomyopathy Patients in a Large Integrated Health System. Journal Of The American Heart Association 2020, 9: e014095. PMID: 31973610, PMCID: PMC7033886, DOI: 10.1161/jaha.119.014095.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedCardiomyopathy, HypertrophicCause of DeathConnecticutDelivery of Health Care, IntegratedFemaleHealthcare DisparitiesHeart Disease Risk FactorsHospitalizationHumansMaleMiddle AgedOutcome and Process Assessment, Health CareReferral and ConsultationRetrospective StudiesRisk AssessmentSocial ClassSocial Determinants of HealthTreatment OutcomeConceptsSpecialty careHCM patientsCare cohortHypertrophic cardiomyopathyYale New Haven Health SystemLarge integrated health systemHealth systemBackground Hypertrophic cardiomyopathyRetrospective cohort studySocioeconomic statusPatients' socioeconomic statusHigher socioeconomic status groupsHypertrophic cardiomyopathy patientsIntegrated health systemSpecialty care accessSocioeconomic status groupsMedical insurance providersCardiomyopathy clinicCause deathLSES patientsCause hospitalizationCause mortalityNoncardiac causesCohort studySecondary outcomes
2017
Dynamic changes in diffusion measures improve sensitivity in identifying patients with mild traumatic brain injury.
Thomas AW, Watts R, Filippi CG, Nickerson JP, Andrews T, Lieberman G, Naylor MR, Eppstein MJ, Freeman K. Dynamic changes in diffusion measures improve sensitivity in identifying patients with mild traumatic brain injury. PLoS One 2017, 12: e0178360. PMID: 28604837, DOI: 10.1371/journal.pone.0178360.Peer-Reviewed Original Research