2010
hI-con1, a factor VII-IgGFc chimeric protein targeting tissue factor for immunotherapy of uterine serous papillary carcinoma
Cocco E, Hu Z, Richter CE, Bellone S, Casagrande F, Bellone M, Todeschini P, Krikun G, Silasi DA, Azodi M, Schwartz PE, Rutherford TJ, Buza N, Pecorelli S, Lockwood CJ, Santin AD. hI-con1, a factor VII-IgGFc chimeric protein targeting tissue factor for immunotherapy of uterine serous papillary carcinoma. British Journal Of Cancer 2010, 103: 812-819. PMID: 20700124, PMCID: PMC2966612, DOI: 10.1038/sj.bjc.6605760.Peer-Reviewed Original ResearchConceptsUSPC cell linesInterleukin-2Tissue factorTF expressionReal-time PCRFactor VIILow HER2/neu expressionCell linesLow dosesPrimary USPC cell linesDependent cell-mediated cytotoxicityUterine serous papillary carcinomaHER2/neu expressionTargeting tissue factorSerous papillary adenocarcinomaStandard treatment modalityCell-mediated cytotoxicityTreatment of patientsNormal endometrial cellsSerous papillary carcinomaNovel therapeutic agentsType II receptorAdenocarcinoma cell lineEndometrial cancerAggressive variantTrop-2 overexpression as an independent marker for poor overall survival in ovarian carcinoma patients
Bignotti E, Todeschini P, Calza S, Falchetti M, Ravanini M, Tassi RA, Ravaggi A, Bandiera E, Romani C, Zanotti L, Tognon G, Odicino FE, Facchetti F, Pecorelli S, Santin AD. Trop-2 overexpression as an independent marker for poor overall survival in ovarian carcinoma patients. European Journal Of Cancer 2010, 46: 944-953. PMID: 20060709, DOI: 10.1016/j.ejca.2009.12.019.Peer-Reviewed Original ResearchConceptsEpithelial ovarian cancerTrop-2 overexpressionTrop-2 expressionOverall survivalPrognostic factorsProtein overexpressionTrop-2 protein expressionMultivariate Cox regression analysisConventional clinicopathological featuresPresence of ascitesCox regression analysisLymph node metastasisOvarian carcinoma patientsPoor overall survivalIndependent prognostic markerNovel prognostic factorUnivariate survival analysisAggressive malignant phenotypeImmunotherapeutic strategiesShort-term cultureCarcinoma patientsClinical courseNode metastasisClinicopathological featuresPrognostic significance
2009
Serum amyloid A
Cocco E, Bellone S, El‐Sahwi K, Cargnelutti M, Buza N, Tavassoli FA, Schwartz PE, Rutherford TJ, Pecorelli S, Santin AD. Serum amyloid A. Cancer 2009, 116: 843-851. PMID: 20041483, PMCID: PMC2819580, DOI: 10.1002/cncr.24838.Peer-Reviewed Original ResearchConceptsEndometrial endometrioid carcinomaSerum amyloid AEndometrioid carcinoma patientsEndometrioid carcinomaNormal endometrial tissuesSAA concentrationsCarcinoma patientsHealthy womenBenign diseaseEndometrial tissuePolymerase chain reactionLiver-secreted proteinsNormal healthy womenExpression levelsReal-time polymerase chain reactionProtein expression levelsG2 patientsDisease recurrenceCarcinoma cell linesEndometrioid carcinoma tissuesSerum biomarkersAmyloid AHealthy groupBead-based immunoassaySerum amyloid
2007
Overexpression of mammaglobin B in epithelial ovarian carcinomas
Tassi RA, Bignotti E, Rossi E, Falchetti M, Donzelli C, Calza S, Ravaggi A, Bandiera E, Pecorelli S, Santin AD. Overexpression of mammaglobin B in epithelial ovarian carcinomas. Gynecologic Oncology 2007, 105: 578-585. PMID: 17343903, DOI: 10.1016/j.ygyno.2007.01.043.Peer-Reviewed Original ResearchConceptsEpithelial ovarian carcinomaHuman ovarian surface epitheliumMammaglobin BOvarian cancerReal-time PCRBenign cystadenomasOvarian carcinomaNormal ovariesNovel ovarian cancer biomarkersB expressionNormal human ovarian surface epitheliumPrimary epithelial ovarian carcinomaSerous papillary ovarian cancerMammaglobin B mRNAMultiple histological typesOvarian cancer biopsiesSerous papillary tumorsClear cell tumorsOvarian surface epitheliumFresh frozen biopsiesOvarian cancer biomarkersParaffin-embedded tissuesMixed histologyBorderline tumorsHistologic type
2005
High serum levels of interleukin-6 in endometrial carcinoma are associated with uterine serous papillary histology, a highly aggressive and chemotherapy-resistant variant of endometrial cancer
Bellone S, Watts K, Cane' S, Palmieri M, Cannon MJ, Burnett A, Roman JJ, Pecorelli S, Santin AD. High serum levels of interleukin-6 in endometrial carcinoma are associated with uterine serous papillary histology, a highly aggressive and chemotherapy-resistant variant of endometrial cancer. Gynecologic Oncology 2005, 98: 92-98. PMID: 15904949, DOI: 10.1016/j.ygyno.2005.03.016.Peer-Reviewed Original ResearchMeSH KeywordsAdultCystadenocarcinoma, PapillaryDrug Resistance, NeoplasmEndometrial NeoplasmsFemaleHumansInterleukin-6Middle AgedNeoplasm StagingPolymerase Chain ReactionConceptsUterine serous papillary carcinomaIL-6 gene expression levelsEndometrioid carcinomaInterleukin-6Primary endometrioid carcinomaEnzyme-linked immunosorbent assayEndometrial carcinomaHealthy femalesUSPC patientsMean serum IL-6 levelPrimary USPC cell linesIL-6 serum concentrationsSerum IL-6 levelsAnti-tumor immune functionBenign abdominal diseasesChemotherapy-resistant variantsControl endometrial cellsNormal healthy femalesSerous papillary histologyUSPC cell linesIL-6 concentrationsIL-6 levelsBenign disease patientsHigher serum levelsSerous papillary carcinoma