2024
Treatment Effect Heterogeneity in Acute Kidney Injury Incidence Following Intravenous Antihypertensive Administration for Severe Blood Pressure Elevation During Hospitalization
Ghazi L, Chen X, Harhay M, Hu L, Biswas A, Peixoto A, Li F, Wilson F. Treatment Effect Heterogeneity in Acute Kidney Injury Incidence Following Intravenous Antihypertensive Administration for Severe Blood Pressure Elevation During Hospitalization. American Journal Of Kidney Diseases 2024 PMID: 39580068, DOI: 10.1053/j.ajkd.2024.09.011.Peer-Reviewed Original ResearchAcute kidney injuryAcute kidney injury incidenceSevere hypertensionIV antihypertensivesAntihypertensive treatmentBlood pressureRisk of acute kidney injuryAbstractText Label="SETTINGS &Blood pressure elevationSevere blood pressure elevationSystolic blood pressureIdentifying treatment optionsAntihypertensive administrationKidney injuryAbstractText Label="RATIONALETreatment optionsAntihypertensive effectBP elevationPressure elevationPatient characteristicsDiastolic BPPatientsKidney failureAntihypertensivesHospital admission
2023
Correlates of Spontaneous Blood Pressure Reduction Following Severe Inpatient Hypertension Development
Garg K, Staunton M, Peixoto A, Wilson F, Ghazi L. Correlates of Spontaneous Blood Pressure Reduction Following Severe Inpatient Hypertension Development. American Journal Of Hypertension 2023, 37: 273-279. PMID: 37988620, DOI: 10.1093/ajh/hpad112.Peer-Reviewed Original ResearchBlood pressure reductionSevere hypertensionBP reductionPressure reductionRetrospective cohort studyChronic pulmonary diseaseMultivariable logistic regressionFuture treatment decisionsAntihypertensive medicationsAntihypertensive therapyCohort studyHypertension developmentBP dropHospitalized patientsPulmonary diseaseTreatment guidelinesBP treatmentWorse outcomesTreatment decisionsCardiac arrythmiasPatientsPotassium levelsHigh potassium levelsLogistic regressionDemographic characteristics
2022
Effect of intravenous antihypertensives on outcomes of severe hypertension in hospitalized patients without acute target organ damage
Ghazi L, Li F, Simonov M, Yamamoto Y, Nugent J, Greenberg J, Bakhoum C, Peixoto A, Wilson F. Effect of intravenous antihypertensives on outcomes of severe hypertension in hospitalized patients without acute target organ damage. Journal Of Hypertension 2022, 41: 288-294. PMID: 36583354, PMCID: PMC9799038, DOI: 10.1097/hjh.0000000000003328.Peer-Reviewed Original ResearchConceptsAcute target organ damageTarget organ damageSevere hypertensionOrgan damageIntravenous antihypertensivesBP elevationClinical outcomesMyocardial injuryTarget end-organ damageOverlap propensity scoreSevere BP elevationAcute kidney injuryBlood pressure reductionEnd-organ damageRisk of strokeInpatient hypertensionCardiovascular eventsIndex hospitalizationKidney injuryRetrospective studyHypertensionAntihypertensivesHospitalizationCox modelPatientsSevere inpatient hypertension prevalence and blood pressure response to antihypertensive treatment
Ghazi L, Li F, Chen X, Simonov M, Yamamoto Y, Biswas A, Hanna J, Shah T, Townsend R, Peixoto A, Wilson FP. Severe inpatient hypertension prevalence and blood pressure response to antihypertensive treatment. Journal Of Clinical Hypertension 2022, 24: 339-349. PMID: 35174627, PMCID: PMC8925013, DOI: 10.1111/jch.14431.Peer-Reviewed Original ResearchConceptsSevere hypertensionBlood pressure responseBP elevationUntreated patientsCox proportional hazards modelRetrospective cohort studyPressure responseProportional hazards modelAntihypertensive treatmentInpatient hypertensionMore comorbiditiesPossible overtreatmentHospitalized adultsCohort studyHypertension prevalenceArterial pressureHospitalized patientsTreatment guidelinesHypertensionGreater rateHazards modelPatientsAntihypertensivesTreatmentAdmission
2020
Chapter 46 Approach to the Patient with Hypertensive Nephrosclerosis
Peixoto A, Bakris G. Chapter 46 Approach to the Patient with Hypertensive Nephrosclerosis. 2020, 737-752. DOI: 10.1016/b978-0-12-815876-0.00046-2.Peer-Reviewed Original ResearchHypertensive nephrosclerosisEnd-stage renal diseaseBlood pressure controlChronic kidney diseaseRenin-angiotensin systemMechanism of injuryArteriolar myogenic responseNonmalignant hypertensionTuft collapseBase therapyImpaired autoregulationUnderlying diseaseRenal diseaseInterstitial fibrosisKidney diseaseGlomerular hypertensionUrine sedimentMyogenic responsePressure controlHypertensionGene mutationsDiseaseNephrosclerosisPatientsProteinuria
2018
Arterial stiffness in elderly patients with normotension and hypertension in Brazil
de Mendonça G, de Souza D, de Alvarenga Cunha Brunelli A, de Oliveira Peres C, Freitas EGB, Lacerda GN, Dorneles MC, Peixoto AJ, Ferreira‐Filho S. Arterial stiffness in elderly patients with normotension and hypertension in Brazil. Journal Of Clinical Hypertension 2018, 20: 1285-1293. PMID: 30039916, PMCID: PMC8031136, DOI: 10.1111/jch.13358.Peer-Reviewed Original ResearchConceptsAortic augmentation indexArterial stiffnessUncontrolled hypertensionCarotid-femoral pulse wave velocityHigher aortic augmentation indexCf-PWV levelsCf-PWV valuesBlood pressure levelsPulse wave velocityCross-sectional analysisElderly patientsAugmentation indexBP levelsCf-PWVEntire cohortNormotensionHypertensionOlder individualsOlder populationPatientsTonometry dataCore measuresCohortPressure levelsIndividuals
2016
Assessment of Hypertension in Chronic Kidney Disease
Peixoto A. Assessment of Hypertension in Chronic Kidney Disease. 2016, 15-33. DOI: 10.1007/978-1-4939-6436-9_2.Peer-Reviewed Original ResearchChronic kidney diseaseKidney diseaseHypertensive patientsAccurate blood pressure measurementHypertension-related outcomesAmbulatory BP monitoringOffice BP measurementsClinical trial evidenceAssessment of hypertensionDiagnosis of hypertensionBlood pressure measurementsAmbulatory BPBP monitoringTrial evidenceOffice readingsBP measurementsUse of homePatientsHypertensionDiseasePreferred methodPressure measurementsDiagnosisPS 08-77 AGREEMENT AMONG SEQUENTIAL CAROTID-FEMORAL PULSE WAVE VELOCITY (CF-PWV) MEASUREMENTS IN ELDERLY HYPERTENSIVE PATIENTS(*)
Souza D, de Alvarenga Brunelli A, Peres C, Dorneles M, de Assis Nolasco G, Mendonca G, Freitas E, Peixoto A, Ferreira-Filho S. PS 08-77 AGREEMENT AMONG SEQUENTIAL CAROTID-FEMORAL PULSE WAVE VELOCITY (CF-PWV) MEASUREMENTS IN ELDERLY HYPERTENSIVE PATIENTS(*). Journal Of Hypertension 2016, 34: e314. DOI: 10.1097/01.hjh.0000500771.66141.71.Peer-Reviewed Original ResearchElderly hypertensive patientsCf-PWV measurementsCf-PWVHypertensive patientsLimits of agreementSupine positionClinical practiceCarotid-femoral pulse wave velocity (PWV) measurementPulse wave velocity measurementAplanation tonometryElderly patientsBland-Altman plotsLin's concordance coefficientSphygmoCor devicePatientsSequential measurementsThird measurementAmbulatory Blood Pressure in Patients with Chronic Kidney Disease
Asch W, Santos S, Peixoto A. Ambulatory Blood Pressure in Patients with Chronic Kidney Disease. Clinical Hypertension And Vascular Diseases 2016, 277-298. DOI: 10.1007/978-3-319-22771-9_14.Peer-Reviewed Original ResearchChronic kidney diseaseKidney diseaseImportant cardiovascular disease risk factorsCardiovascular disease risk factorsChronic kidney disease progressionHome blood pressure monitoringAbnormal BP profileOffice BP measuresKidney disease progressionAmbulatory blood pressureDisease risk factorsBlood pressure monitoringOffice BPBP profileBlood pressureEssential hypertensionAdverse outcomesBP measuresDisease burdenRisk factorsDisease progressionGeneral populationPressure monitoringPatientsDisease
2015
Managing Blood Pressure in the Elderly: What Is Different?
Santos S, Pazhayattil G, Peixoto A. Managing Blood Pressure in the Elderly: What Is Different? 2015, 67-83. DOI: 10.1007/978-1-4939-3320-4_7.Peer-Reviewed Original ResearchEnd-stage kidney diseaseManagement of BPMaintenance dialysisCommon cardiovascular risk factorsChronic maintenance dialysisCardiovascular risk factorsBlood pressure managementTreatment of hypertensionElderly patientsBlood pressureDialysis patientsKidney diseaseRisk factorsPatientsAge groupsPressure managementAging processHypertensionDialysisManagementDiseaseElderlyChapter 38 Approach to the Patient with Hypertensive Nephrosclerosis
Peixoto A, Bakris G. Chapter 38 Approach to the Patient with Hypertensive Nephrosclerosis. 2015, 455-469. DOI: 10.1016/b978-0-12-411602-3.00038-x.Peer-Reviewed Original ResearchHypertensive nephrosclerosisEnd-stage renal diseaseNon-malignant hypertensionBlood pressure controlChronic kidney diseaseRenin-angiotensin systemMechanism of injuryArteriolar myogenic responseTuft collapseBase therapyImpaired autoregulationUnderlying diseaseRenal diseaseInterstitial fibrosisKidney diseaseGlomerular hypertensionUrine sedimentMyogenic responsePressure controlGene mutationsDiseaseNephrosclerosisHypertensionPatientsProteinuria
2007
Ambulatory Blood Pressure in Patients With Chronic Kidney Disease
Santos S, Peixoto A. Ambulatory Blood Pressure in Patients With Chronic Kidney Disease. Clinical Hypertension And Vascular Diseases 2007, 389-410. DOI: 10.1007/978-1-59259-978-3_16.Peer-Reviewed Original ResearchChronic kidney diseaseEnd-stage renal diseaseKidney diseaseCases of CKDAmbulatory blood pressureSetting of diabetesAdult US populationHealth care resourcesHealth care problemIncidence of adultESRD patientsBlood pressureRenal diseaseCurrent prevalenceCare resourcesUS populationCare problemsPrevalenceDiseaseHypertensionPatientsSignificant rateMorbidityDiabetesMortality
2000
Reproducibility of ambulatory blood pressure monitoring in hemodialysis patients
Peixoto A, Santos S, Mendes R, Crowley S, Maldonado R, Orias M, Mansoor G, White W. Reproducibility of ambulatory blood pressure monitoring in hemodialysis patients. American Journal Of Kidney Diseases 2000, 36: 983-990. PMID: 11054355, DOI: 10.1053/ajkd.2000.19100.Peer-Reviewed Original ResearchConceptsAmbulatory blood pressure monitoringInterdialytic ambulatory blood pressure monitoringBlood pressure monitoringPost-HD valuesHD patientsPressure monitoringReproducibility of ABPMDrug regimenHemodialysis patientsHemodialysis practiceHD sessionNocturnal declineInterdialytic periodPatientsBP determinationRegimenPeriodSleepCoefficient of variationK028: Prediction of interdialytic ambulatory blood pressure in 91 hemodialysis patients
Santos S, Mendes R, Crowley S, Mansoor G, White W, Peixoto A. K028: Prediction of interdialytic ambulatory blood pressure in 91 hemodialysis patients. American Journal Of Hypertension 2000, 13: 290a-291a. DOI: 10.1016/s0895-7061(00)01059-1.Peer-Reviewed Original ResearchPost-HD valuesHemodialysis patientsInterdialytic ambulatory blood pressureMean dialysis timeAmbulatory blood pressureInterdialytic weight gainSBP/DBPPre-HD levelsMidweek HD sessionInterdialytic BPMean ultrafiltrationAmbulatory BPBlood pressureBP levelsInterdialytic dayBP managementHD sessionNocturnal declineDaily BPHD subjectsClinical decisionDialysis timeWeight gainStrongest predictorPatientsC037: Reproducibility of ambulatory blood pressure in hemodialysis patients
Peixoto A, Santos S, Mendes R, Crowley S, Orias M, Maldonado R, Mansoor G, White W. C037: Reproducibility of ambulatory blood pressure in hemodialysis patients. American Journal Of Hypertension 2000, 13: 223a-223a. DOI: 10.1016/s0895-7061(00)00757-3.Peer-Reviewed Original Research
1999
Validation of the SpaceLabs 90207 ambulatory blood pressure device for hemodialysis patients
Peixoto A, Gray T, Crowley S. Validation of the SpaceLabs 90207 ambulatory blood pressure device for hemodialysis patients. Blood Pressure Monitoring 1999, 4: 217-226. PMID: 10547641, DOI: 10.1097/00126097-199900450-00003.Peer-Reviewed Original ResearchConceptsSystolic blood pressureDiastolic blood pressureAmbulatory blood pressure monitoringAmbulatory blood pressure deviceBlood pressureBlood pressure deviceHemodialysis patientsMean differenceBritish Hypertension Society protocolMean blood pressureBlood pressure monitoringBritish Hypertension Society criteriaPressure deviceMethod of BlandDialysis patientsLimits of agreementVascular accessArteriovenous graftsIpsilateral armSociety criteriaPressure monitoringGrade CPatientsGrade BHemodialysis