2007
Semaphorin3a disrupts podocyte foot processes causing acute proteinuria
Tapia R, Guan F, Gershin I, Teichman J, Villegas G, Tufro A. Semaphorin3a disrupts podocyte foot processes causing acute proteinuria. Kidney International 2007, 73: 733-740. PMID: 18075495, DOI: 10.1038/sj.ki.5002726.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAnimalsCytoskeletal ProteinsDown-RegulationGlomerular Basement MembraneGlomerular Filtration RateIntracellular Signaling Peptides and ProteinsMaleMembrane ProteinsMiceMice, Inbred StrainsPermeabilityPodocytesProteinuriaRecombinant ProteinsSemaphorin-3AVascular Endothelial Growth Factor AVascular Endothelial Growth Factor Receptor-1Vascular Endothelial Growth Factor Receptor-2ConceptsPodocyte foot process effacementNephrotic range proteinuriaEndothelial cell damageVascular endothelial growth factorSlit diaphragm protein podocinFoot process effacementEndothelial growth factorReceptor 2 signalingVascular endothelial growth factor receptor 2 signalingAcute proteinuriaRange proteinuriaReceptor expressionVascular endothelial growth factor 165Process effacementBarrier homeostasisAdult mouse kidneyUltrastructural abnormalitiesSemaphorin3AEndothelial cellsCell damageGrowth factorMouse kidneyGuidance proteinsProteinuriaDownregulation
2006
Autocrine VEGF-A system in podocytes regulates podocin and its interaction with CD2AP
Guan F, Villegas G, Teichman J, Mundel P, Tufro A. Autocrine VEGF-A system in podocytes regulates podocin and its interaction with CD2AP. American Journal Of Physiology. Renal Physiology 2006, 291: f422-f428. PMID: 16597608, DOI: 10.1152/ajprenal.00448.2005.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAnimalsC-Reactive ProteinCell DifferentiationCell LineCell SurvivalCytoskeletal ProteinsGene Expression RegulationIntracellular Signaling Peptides and ProteinsMembrane ProteinsMiceNerve Tissue ProteinsNeuropilin-2PodocytesProteinsProto-Oncogene Proteins c-aktReceptors, Vascular Endothelial Growth FactorRNA, MessengerSignal TransductionVascular Endothelial Growth Factor AVascular Endothelial Growth Factor Receptor-1Vascular Endothelial Growth Factor Receptor-2ConceptsWestern analysisAutocrine VEGFPodocyte VEGFGrowth factor signalingVEGFR2 mRNA levelsMRNA levelsEndothelial cell differentiationVascular endothelial growth factor signalingCompletion of developmentVascular patterningKidney morphogenesisFactor signalingPodocyte differentiationUndifferentiated podocytesLigand availabilityCell differentiationVEGFR2 phosphorylationDifferentiated conditionsImmortalized mouse podocytesProtein levelsProtein expressionMouse podocytesVEGFR2 mRNADifferentiated podocytesCD2AP