2024
Design and development of the DE-SPECT system: a clinical SPECT system for broadband multi-isotope imaging of peripheral vascular disease
Zannoni E, Sankar P, Jin Y, Liu C, Sinusas A, Metzler S, Meng L. Design and development of the DE-SPECT system: a clinical SPECT system for broadband multi-isotope imaging of peripheral vascular disease. Physics In Medicine And Biology 2024, 69: 125016. PMID: 38815617, PMCID: PMC11167601, DOI: 10.1088/1361-6560/ad5266.Peer-Reviewed Original ResearchMeSH KeywordsCadmiumEquipment DesignHumansImage Processing, Computer-AssistedPeripheral Vascular DiseasesPhantoms, ImagingTelluriumTomography, Emission-Computed, Single-PhotonZincConceptsCadmium zinc tellurideSPECT systemField of viewExcellent spectroscopic performanceExcellent energy resolutionBroad energy rangeIntrinsic spatial resolutionSpatial resolutionClinical SPECT systemEnergy resolutionPeripheral vascular diseaseEnergy rangeMm FWHMSpectroscopic performanceZinc tellurideWide-FOVCollimatorPreliminary experimental dataPartial ringDetection systemImaging capabilitiesImaging performanceExtremity imagingVascular diseaseScout images
2023
DuSFE: Dual-Channel Squeeze-Fusion-Excitation co-attention for cross-modality registration of cardiac SPECT and CT
Chen X, Zhou B, Xie H, Guo X, Zhang J, Duncan J, Miller E, Sinusas A, Onofrey J, Liu C. DuSFE: Dual-Channel Squeeze-Fusion-Excitation co-attention for cross-modality registration of cardiac SPECT and CT. Medical Image Analysis 2023, 88: 102840. PMID: 37216735, PMCID: PMC10524650, DOI: 10.1016/j.media.2023.102840.Peer-Reviewed Original ResearchMeSH KeywordsHeartHumansImage Processing, Computer-AssistedPhantoms, ImagingTomography, Emission-Computed, Single-PhotonTomography, X-Ray ComputedConceptsCross-modality registrationConvolutional layersCo-attention mechanismMultiple convolutional layersCo-attention moduleDifferent convolutional layersMedical image registrationInput data streamDeep learning strategiesLow registration errorIntensity-based registration methodCardiac SPECTΜ-mapsDeep learningFeature fusionData streamsInput imageSource codeFeature mapsNeural networkImage registrationSpatial featuresRegistration performanceRegistration methodInput information
2019
Flow network tracking for spatiotemporal and periodic point matching: Applied to cardiac motion analysis
Parajuli N, Lu A, Ta K, Stendahl J, Boutagy N, Alkhalil I, Eberle M, Jeng GS, Zontak M, O'Donnell M, Sinusas AJ, Duncan JS. Flow network tracking for spatiotemporal and periodic point matching: Applied to cardiac motion analysis. Medical Image Analysis 2019, 55: 116-135. PMID: 31055125, PMCID: PMC6939679, DOI: 10.1016/j.media.2019.04.007.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsAnimalsDogsEchocardiographyImage Processing, Computer-AssistedImaging, Three-DimensionalMotionNeural Networks, ComputerVentricular Dysfunction, LeftConceptsDeformation/strainExcellent tracking accuracyEntire cardiac cycleTracking accuracyCardiac motion analysisAccurate estimationSurface pointsEchocardiographic image sequencesLV motionDisplacementMotion analysisImage sequencesCardiac cyclePoint matchingMotionConsecutive framesEstimationNetwork trackingImportant characteristicsSignificant promiseSchemeGood correlationFlow
2017
Fully automatic multi-atlas segmentation of CTA for partial volume correction in cardiac SPECT/CT
Liu Q, Mohy-ud-Din H, Boutagy N, Jiang M, Ren S, Stendahl J, Sinusas A, Liu C. Fully automatic multi-atlas segmentation of CTA for partial volume correction in cardiac SPECT/CT. Physics In Medicine And Biology 2017, 62: 3944-3957. PMID: 28266929, PMCID: PMC5568763, DOI: 10.1088/1361-6560/aa6520.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsAngiographyAnimalsAutomationBlood VolumeDogsHeartHumansImage Processing, Computer-AssistedSingle Photon Emission Computed Tomography Computed TomographyConceptsMulti-atlas segmentation methodLabel fusion methodMulti-atlas segmentationSegmentation methodConventional label fusion methodsFusion methodManual segmentationMultiple organ segmentationLabel fusion algorithmImage qualityCardiac SPECT imagesDice similarity coefficientOrgan segmentationSegmentation accuracyAutomatic segmentationCTA segmentationFusion algorithmComputed tomography angiography dataSegmentationOne-out approachCT datasetsTomography angiography dataSimilarity coefficientAngiography dataConsistent image quality
2015
Simultaneous CT-MRI Reconstruction for Constrained Imaging Geometries Using Structural Coupling and Compressive Sensing
Xi Y, Zhao J, Bennett J, Stacy M, Sinusas A, Wang G. Simultaneous CT-MRI Reconstruction for Constrained Imaging Geometries Using Structural Coupling and Compressive Sensing. IEEE Transactions On Biomedical Engineering 2015, 63: 1301-1309. PMID: 26672028, PMCID: PMC4930897, DOI: 10.1109/tbme.2015.2487779.Peer-Reviewed Original ResearchMeSH KeywordsHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingPhantoms, ImagingTomography, X-Ray ComputedConceptsMRI image reconstructionImage estimation methodCompressive sensing techniquesUnified reconstruction frameworkNovel research directionsMRI reconstructionReconstruction frameworkCompressive sensingImage reconstructionPrior knowledgeDifferent modalitiesReconstruction methodologyResearch directionsInstantaneous acquisitionMRI dataPromising resultsImaging geometrySeparate reconstructionBetter CTNumerical phantomImproved resultsMRI acquisitionSensing techniquesEstimation methodApplications
2011
Targeted Imaging of the Spatial and Temporal Variation of Matrix Metalloproteinase Activity in a Porcine Model of Postinfarct Remodeling
Sahul ZH, Mukherjee R, Song J, McAteer J, Stroud RE, Dione DP, Staib L, Papademetris X, Dobrucki LW, Duncan JS, Spinale FG, Sinusas AJ. Targeted Imaging of the Spatial and Temporal Variation of Matrix Metalloproteinase Activity in a Porcine Model of Postinfarct Remodeling. Circulation Cardiovascular Imaging 2011, 4: 381-391. PMID: 21505092, PMCID: PMC3140564, DOI: 10.1161/circimaging.110.961854.Peer-Reviewed Original Research
2001
Estimation of 3D left ventricular deformation from echocardiography
Papademetris X, Sinusas A, Dione D, Duncan J. Estimation of 3D left ventricular deformation from echocardiography. Medical Image Analysis 2001, 5: 17-28. PMID: 11231174, DOI: 10.1016/s1361-8415(00)00022-0.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiomechanical PhenomenaDogsEchocardiography, Three-DimensionalHeart VentriclesImage Processing, Computer-AssistedModels, StatisticalVentricular Function, LeftConceptsDense motion fieldIsotropic linear elastic modelRegional cardiac deformationLinear elastic modelMotion fieldTerms of strainCardiac deformationFiber directionElastic modelDeformationHeart wallGood agreementHeart deformationImage sequencesWallEstimationSpecific directionUltrasound imagesQuantitative estimationInitial correspondenceField
2000
Assessment of left ventricular ejection fraction with quantitative gated SPECT: Accuracy and correlation with first-pass radionuclide angiography
Vallejo E, Dione D, Sinusas A, Wackers F. Assessment of left ventricular ejection fraction with quantitative gated SPECT: Accuracy and correlation with first-pass radionuclide angiography. Journal Of Nuclear Cardiology 2000, 7: 461-470. PMID: 11083195, DOI: 10.1067/mnc.2000.107820.Peer-Reviewed Original ResearchConceptsVentricular ejection fractionEjection fractionPatient studiesLeft ventricular ejection fractionExtracardiac activityFirst-pass radionuclide angiographyLarger end-diastolic volumeStress-induced ischemiaEnd-diastolic volumeQuantitative gated SPECTSingle photon emissionAbnormal LVEFNormal LVEFRadionuclide angiographyDiastolic volumeLVEFPerfusion defectsLVEF valuesSame patientHeart sizeLeft ventricleGated SPECTSPECT studiesQGSMean rest
1999
Quantification of regional myocardial wall thickening on electrocardiogram-gated SPECT imaging
Shen M, Liu Y, Sinusas A, Fetterman R, Bruni W, Drozhinin O, Zaret B, Wackers F. Quantification of regional myocardial wall thickening on electrocardiogram-gated SPECT imaging. Journal Of Nuclear Cardiology 1999, 6: 583-595. PMID: 10608585, DOI: 10.1016/s1071-3581(99)90095-8.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsComputer SimulationDiastoleElectrocardiographyHeart VentriclesHumansImage Processing, Computer-AssistedModels, CardiovascularMyocardial InfarctionObserver VariationPhantoms, ImagingPilot ProjectsRadiopharmaceuticalsReproducibility of ResultsSoftwareSystoleTechnetium Tc 99m SestamibiTomography, Emission-Computed, Single-PhotonVentricular Function, LeftVentricular RemodelingVentriculography, First-PassConceptsPrior myocardial infarctionRegional wall thickeningNormal subjectsMyocardial infarctionWall thickeningNormal wall thickeningPilot studyRegional left ventricular functionLeft ventricular functionAbnormal wall thickeningPercent count increaseECG-gated SPECT imagesSingle photon emissionSPECT imagesCardiac cycleLeft ventricular wallReproducibility of interpretationRegional left ventricular wallPrior infarctionCoronary diseaseVentricular functionValidation studyInfarct areaNormal rangeAnatomic areasQuantification of SPECT myocardial perfusion images: Methodology and validation of the Yale-CQ method
Liu Y, Sinusas A, DeMan P, Zaret B, Wackers F. Quantification of SPECT myocardial perfusion images: Methodology and validation of the Yale-CQ method. Journal Of Nuclear Cardiology 1999, 6: 190-203. PMID: 10327104, DOI: 10.1016/s1071-3581(99)90080-6.Peer-Reviewed Original Research
1998
Physical and geometrical modeling for image-based recovery of left ventricular deformation
Duncan J, Shi P, Constable T, Sinusas A. Physical and geometrical modeling for image-based recovery of left ventricular deformation. Progress In Biophysics And Molecular Biology 1998, 69: 333-351. PMID: 9785945, DOI: 10.1016/s0079-6107(98)00014-5.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiomechanical PhenomenaHeartHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingModels, CardiovascularMyocardial IschemiaVentricular Dysfunction, LeftVentricular Function, Left
1996
Quantitative comparison of single-isotope and dual-isotope stress-rest single-photon emission computed tomographic imaging for reversibility of defects
Siebelink H, Natale D, Sinusas A, Wackers F. Quantitative comparison of single-isotope and dual-isotope stress-rest single-photon emission computed tomographic imaging for reversibility of defects. Journal Of Nuclear Cardiology 1996, 3: 483-493. PMID: 8989673, DOI: 10.1016/s1071-3581(96)90058-6.Peer-Reviewed Original ResearchMeSH KeywordsDipyridamoleExercise TestFemaleHeartHumansImage Processing, Computer-AssistedMaleMiddle AgedMyocardial InfarctionTechnetium Tc 99m SestamibiThallium RadioisotopesTomography, Emission-Computed, Single-PhotonVasodilator AgentsConceptsDefect reversibilitySingle photon emissionDual-isotope SPECTNormal databaseStress-rest single-photon emissionTechnetium 99m-labeled sestamibiStress-induced myocardial ischemiaStress single-photon emissionPerfusion defect reversibilityPrior myocardial infarctionDefect sizeRest/stressSingle-isotope imagingMyocardial infarctionThallium SPECTMyocardial ischemiaIndividual patientsMyocardial perfusionThallium-201PatientsSestamibiCircumferential count profilesTomographic imagingImaging protocolDual-isotope imaging
1994
Development and evaluation of tracking algorithms for cardiac wall motion analysis using phase velocity MR imaging
Constable R, Rath K, Sinusas A, Gore J. Development and evaluation of tracking algorithms for cardiac wall motion analysis using phase velocity MR imaging. Magnetic Resonance In Medicine 1994, 32: 33-42. PMID: 8084235, DOI: 10.1002/mrm.1910320106.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsAnimalsComputer SimulationDogsHeartHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingModels, CardiovascularModels, StructuralMyocardial ContractionMyocardial InfarctionIntracoronary Ethanol Ablation in Swine:
HAINES D, VEROW A, SINUSAS A, WHAYNE J, DiMARCO J. Intracoronary Ethanol Ablation in Swine:. Journal Of Cardiovascular Electrophysiology 1994, 5: 41-49. PMID: 8186876, DOI: 10.1111/j.1540-8167.1994.tb01113.x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsArrhythmias, CardiacBlood PressureCatheter AblationDisease Models, AnimalEthanolGamma CamerasHemodynamicsImage Processing, Computer-AssistedInjections, IntralesionalMyocardial Reperfusion InjuryNecrosisSwineConceptsIntracoronary ethanol ablationVentricular ejection fractionPerfusion bedAblation bedEjection fractionEthanol ablationChemical ablationLeft ventricular ejection fractionCoronary blood supplySignificant ventricular arrhythmiasCircumflex coronary arteryLeft anterior descendingTreatment of arrhythmiasDistribution of necrosisCoronary artery bedArterial pressureMethoxyisobutyl isonitrileSignificant arrhythmiasAnterior descendingIntracoronary infusionVentricular arrhythmiasCoronary arteryCoronary bedCoronary branchesHemodynamic parameters