2023
Unsupervised learning to characterize patients with known coronary artery disease undergoing myocardial perfusion imaging
Williams M, Bednarski B, Pieszko K, Miller R, Kwiecinski J, Shanbhag A, Liang J, Huang C, Sharir T, Dorbala S, Di Carli M, Einstein A, Sinusas A, Miller E, Bateman T, Fish M, Ruddy T, Acampa W, Hauser M, Kaufmann P, Dey D, Berman D, Slomka P. Unsupervised learning to characterize patients with known coronary artery disease undergoing myocardial perfusion imaging. European Journal Of Nuclear Medicine And Molecular Imaging 2023, 50: 2656-2668. PMID: 37067586, PMCID: PMC10317876, DOI: 10.1007/s00259-023-06218-z.Peer-Reviewed Original ResearchConceptsCoronary artery diseaseMyocardial perfusion imagingCause mortalityTotal perfusion deficitArtery diseaseRisk stratificationPerfusion deficitsHigher body mass indexTomography myocardial perfusion imagingMore diabetes mellitusSPECT myocardial perfusion imagingBetter risk stratificationRisk-stratify patientsBody mass indexREFINE SPECT registrySingle photon emissionDiabetes mellitusMass indexExternal cohortStress imagingMyocardial perfusionPatientsRisk phenotypePerfusion imagingImaging characteristics
2021
Impact of age, sex, and cardiac size on the diagnostic performance of myocardial perfusion single-photon emission computed tomography: insights from the REFINE SPECT registry
Randazzo M, Elias P, Poterucha T, Sharir T, Fish M, Ruddy T, Kaufmann P, Sinusas A, Miller E, Bateman T, Dorbala S, Di Carli M, Berman D, Slomka P, Einstein A. Impact of age, sex, and cardiac size on the diagnostic performance of myocardial perfusion single-photon emission computed tomography: insights from the REFINE SPECT registry. European Heart Journal 2021, 42: ehab724.0254. DOI: 10.1093/eurheartj/ehab724.0254.Peer-Reviewed Original ResearchCoronary artery diseaseElderly patientsImpact of ageSingle photon emissionDiagnostic performanceYounger patientsFemale patientsCardiac sizeSPECT-MPILower EDVCardiac volumesObstructive coronary artery diseasePrediction of CADTomography myocardial perfusion imagingMyocardial perfusion single-photon emissionDiagnostic accuracyPerfusion single-photon emissionCardiac event rateStress total perfusion deficitReceiver-operating characteristic curveInvasive coronary angiographyEnd-diastolic volumeCardiac chamber sizeAlternative diagnostic modalityTotal perfusion deficit
2020
Coronary Computed Tomography Angiography Compared With Single Photon Emission Computed Tomography Myocardial Perfusion Imaging as a Guide to Optimal Medical Therapy in Patients Presenting With Stable Angina: The RESCUE Trial
Stillman A, Gatsonis C, Lima J, Liu T, Snyder B, Cormack J, Malholtra V, Schnall M, Udelson J, Hoffmann U, Woodard P, Kim M, Hegde V, Kenny, Afaq M, Clouse M, Malhotra V, Cole, Al‐Khori F, Scherer M, Rothenberg F, Kirsch J, Shah A, Quyyumi A, Engberding N, Becker C, Li D, Pantelic M, Duerinckx A, Martin, Schrank J, Zachariah, Jacob R, Borges A, Roberge E, Truong Q, Edelman R, Akers S, Marsh K, Kemp, Reingold J, Chilakapati V, Osborne J, Lui K, Gomes A, Bajpai A, del Rio J, Singh, Thompson B, Rivard A, Jha S, Mavromatis K, Woodard P, Sinusas A. Coronary Computed Tomography Angiography Compared With Single Photon Emission Computed Tomography Myocardial Perfusion Imaging as a Guide to Optimal Medical Therapy in Patients Presenting With Stable Angina: The RESCUE Trial. Journal Of The American Heart Association 2020, 9: e017993. PMID: 33283579, PMCID: PMC7955393, DOI: 10.1161/jaha.120.017993.Peer-Reviewed Original ResearchConceptsMajor adverse cardiovascular eventsOptimal medical therapyAcute myocardial infarctionMedical therapyStable anginaMyocardial perfusion imagingMyocardial infarctionSingle photon emissionNegative CCTAHazard ratioRescue trialPerfusion imagingFirst major adverse cardiovascular eventTomography myocardial perfusion imagingSPECT myocardial perfusion imagingAdverse cardiovascular eventsOutcomes of patientsTomography myocardial perfusionFirst imaging testPhoton emissionCCTA armPositive CCTACardiovascular eventsSegment involvementOutcome trials