Comparative study of functional and structural muscle changes in peripheral artery disease: rubidium-82 positron emission tomography and histological correlation
Alashi A, Vermillion B, Callegari S, Burns R, Guo L, Moulton E, Guerrera N, Depino A, Papademetris X, Zeiss C, Thorn S, Liu C, Sinusas A. Comparative study of functional and structural muscle changes in peripheral artery disease: rubidium-82 positron emission tomography and histological correlation. European Heart Journal - Cardiovascular Imaging 2024, 25: jeae142.087. DOI: 10.1093/ehjci/jeae142.087.Peer-Reviewed Original ResearchPeripheral arterial diseaseStandardized uptake valueHindlimb ischemia modelReactive hyperemiaSkeletal muscle perfusionPerfusion reserveCapillary densityPET imagingArtery diseaseNon-ischemicRubidium-82 positron emission tomographyType 2 muscle fibersRelevant pre-clinical modelIndicative of fibrosisManagement of peripheral arterial diseaseCapillary to muscle fiber ratioClinically relevant pre-clinical modelPre-clinical modelsMuscle perfusionFast myosinWeeks post-ligationRb-82 uptakeEvaluate treatment strategiesRabbit hindlimb ischemia modelPositron emission tomographyClinical physiology: the crucial role of MRI in evaluation of peripheral artery disease
Elsaid N, Peters D, Galiana G, Sinusas A. Clinical physiology: the crucial role of MRI in evaluation of peripheral artery disease. AJP Heart And Circulatory Physiology 2024, 326: h1304-h1323. PMID: 38517227, PMCID: PMC11381027, DOI: 10.1152/ajpheart.00533.2023.Peer-Reviewed Original ResearchPeripheral arterial diseaseMagnetic resonance imagingArtery diseaseClinical applicationEvaluation of peripheral arterial diseaseTranslation to clinical researchPre-clinical modelsMedial vascular calcificationDiagnosis of peripheral arterial diseaseExcellent soft tissue contrastPathophysiology of peripheral arterial diseaseAssessment of peripheral arterial diseaseNoninvasive imaging toolMR imaging technologyMR imaging techniquesSoft tissue contrastMultiplanar imaging capabilityAutonomic dysfunctionMicrovascular dysfunctionRisk stratificationPeripheral neuropathyComprehensive physiological assessmentTreatment outcomesVascular calcificationTherapy planning