2023
Multiaxial pressure-strain analysis of regional myocardial work in the setting of graded coronary stenoses and dobutamine stress
Stendahl J, Liu Z, Boutagy N, Parajuli N, Lu A, Alkhalil I, Lin B, Duncan J, Sinusas A. Multiaxial pressure-strain analysis of regional myocardial work in the setting of graded coronary stenoses and dobutamine stress. AJP Heart And Circulatory Physiology 2023, 325: h492-h509. PMID: 37417870, PMCID: PMC10538990, DOI: 10.1152/ajpheart.00735.2022.Peer-Reviewed Original ResearchConceptsLow-dose dobutaminePressure-strain loopsCoronary stenosisMyocardial workRegional myocardial workPressure-strain analysisDobutamine stressBlood flowLow-dose dobutamine stressInvasive hemodynamic monitoringMid-left anteriorLow cardiac outputRegional myocardial blood flowCoronary blood flowIschemic heart diseasePresence of ischemiaMyocardial work indexModerate coronary stenosisMyocardial blood flowOpen-chest modelEjection of bloodInotropic supportPressure-strain relationshipHemodynamic monitoringCardiac output
2000
Severe regional ischemia alters coronary flow reserve in the remote perfusion area
Wu J, Yun J, Dione D, Heller E, Deckelbaum L, Sinusas A. Severe regional ischemia alters coronary flow reserve in the remote perfusion area. Journal Of Nuclear Cardiology 2000, 7: 43-52. PMID: 10698234, DOI: 10.1067/mnc.2000.99189.Peer-Reviewed Original ResearchConceptsLAD coronary flow reserveCoronary flow reserveLCX stenosisFlow reserveImpairment of CFRStenosis severityRemote nonischemic regionsRate-pressure productRegional myocardial dysfunctionDoppler flow probesTransstenotic pressure gradientOpen-chest dogsAcute canine modelIschemic dysfunctionAnterior descendingIntracoronary injectionMyocardial dysfunctionProximal LCXCoronary stenosisMyocardial infarctionAcute ischemiaProgressive impairmentPerfusion areaRegional myocardial flowTransstenotic gradient