2022
Gut microbiome dysbiosis in antibiotic-treated COVID-19 patients is associated with microbial translocation and bacteremia
Bernard-Raichon L, Venzon M, Klein J, Axelrad J, Zhang C, Sullivan A, Hussey G, Casanovas-Massana A, Noval M, Valero-Jimenez A, Gago J, Putzel G, Pironti A, Wilder E, Thorpe L, Littman D, Dittmann M, Stapleford K, Shopsin B, Torres V, Ko A, Iwasaki A, Cadwell K, Schluter J. Gut microbiome dysbiosis in antibiotic-treated COVID-19 patients is associated with microbial translocation and bacteremia. Nature Communications 2022, 13: 5926. PMID: 36319618, PMCID: PMC9626559, DOI: 10.1038/s41467-022-33395-6.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnti-Bacterial AgentsBacteremiaBacteriaCoinfectionCOVID-19DysbiosisGastrointestinal MicrobiomeMiceSARS-CoV-2ConceptsGut microbiome dysbiosisCOVID-19 patientsMicrobiome dysbiosisSecondary infectionSARS-CoV-2 infection inducesLife-threatening secondary infectionsTranslocation of bacteriaBlood culture resultsCOVID-19 severityAntimicrobial-resistant speciesCOVID-19Different clinical sitesMicrobial translocationBloodstream infectionsInfection inducesBarrier permeabilitySystemic circulationDysbiosisGoblet cellsPaneth cellsClinical sitesCulture resultsPatient healthGut microbiomePatients
2000
Clonally Related Penicillin-Nonsusceptible Streptococcus pneumoniae Serotype 14 from Cases of Meningitis in Salvador, Brazil
Ko A, Reis J, Coppola S, Gouveia E, Cordeiro S, Lôbo T, Pinheiro R, Salgado K, Dourado C, Tavares-Neto J, Rocha H, Reis M, Johnson W, Riley L. Clonally Related Penicillin-Nonsusceptible Streptococcus pneumoniae Serotype 14 from Cases of Meningitis in Salvador, Brazil. Clinical Infectious Diseases 2000, 30: 78-86. PMID: 10619737, DOI: 10.1086/313619.Peer-Reviewed Original ResearchConceptsPenicillin-nonsusceptible isolatesSerotype 14 isolatesSerotype 14Pneumococcal meningitisActive hospital-based surveillanceCases of meningitisHospital-based surveillancePrevious antibiotic useIntermediate-level resistanceSerotype 14 strainsPolymerase chain reaction analysisAntibiotic useChain reaction analysisPrevalent serotypesMeningitisUnrelated patternsPCR patternsCity of SalvadorPatientsStreptococcus pneumoniae serotype 14Reaction analysisIsolatesLarge proportionGeographic areasInfection