Escape of TLR5 Recognition by Leptospira spp.: A Rationale for Atypical Endoflagella
Holzapfel M, Bonhomme D, Cagliero J, Vernel-Pauillac F, d’Andon M, Bortolussi S, Fiette L, Goarant C, Wunder EA, Picardeau M, Ko AI, Werling D, Matsui M, Boneca IG, Werts C. Escape of TLR5 Recognition by Leptospira spp.: A Rationale for Atypical Endoflagella. Frontiers In Immunology 2020, 11: 2007. PMID: 32849665, PMCID: PMC7431986, DOI: 10.3389/fimmu.2020.02007.Peer-Reviewed Original ResearchConceptsTLR5 recognitionHuman Toll-like receptorsTLR5-deficient miceToll-like receptorsInnate immune recognitionNOD-like receptorsBacterial cell wall componentsHeat-killed bacteriaInflammatory roleDeficient miceTLR5 activationImmune responseLive leptospiresTLR5Immune recognitionLive strainsStealth pathogenWorldwide zoonosisHost defenseBovine TLR5TLR5 activityLeptospira sppInfectionLeptospiresCentral localizationAn asymmetric sheath controls flagellar supercoiling and motility in the leptospira spirochete
Gibson KH, Trajtenberg F, Wunder EA, Brady MR, San Martin F, Mechaly A, Shang Z, Liu J, Picardeau M, Ko A, Buschiazzo A, Sindelar CV. An asymmetric sheath controls flagellar supercoiling and motility in the leptospira spirochete. ELife 2020, 9: e53672. PMID: 32157997, PMCID: PMC7065911, DOI: 10.7554/elife.53672.Peer-Reviewed Original ResearchConceptsCryo-electron tomographyKey functional attributesNative flagellar filamentsHigh-resolution cryo-electron tomographyPeriplasmic spaceSheath proteinStructural basisFlagellar filamentsLeptospira spirochetesSpirochete bacteriaEntire cellFunctional attributesX-ray crystallographyImportant pathogenSupercoilingMotilityBacteriaFilamentsCell bodiesFlagellaSpirochetesProteinFlagellinDistinctive meansEndoflagella