2022
EVITA Dengue: a cluster-randomized controlled trial to EValuate the efficacy of Wolbachia-InfecTed Aedes aegypti mosquitoes in reducing the incidence of Arboviral infection in Brazil
Collins MH, Potter GE, Hitchings MDT, Butler E, Wiles M, Kennedy JK, Pinto SB, Teixeira ABM, Casanovas-Massana A, Rouphael NG, Deye GA, Simmons CP, Moreira LA, Nogueira ML, Cummings DAT, Ko AI, Teixeira MM, Edupuganti S. EVITA Dengue: a cluster-randomized controlled trial to EValuate the efficacy of Wolbachia-InfecTed Aedes aegypti mosquitoes in reducing the incidence of Arboviral infection in Brazil. Trials 2022, 23: 185. PMID: 35236394, PMCID: PMC8889395, DOI: 10.1186/s13063-022-05997-4.Peer-Reviewed Original ResearchConceptsArboviral infectionsMajor global health problemHigh-quality evidenceCluster-randomized trialGlobal health problemNational InstituteEfficacy of WolbachiaWorld Mosquito ProgramArbovirus transmissionOngoing trialsLicensed antiviralsAedes aegypti mosquitoesEffective vaccineTrial designMosquito ProgramSerologic surveillanceHealth problemsHuman infectionsAedes aegyptiInfectionEpidemiologic outcomesVector control activitiesTrialsAegypti mosquitoesAedes mosquitoes
2019
Impact of preexisting dengue immunity on Zika virus emergence in a dengue endemic region
Rodriguez-Barraquer I, Costa F, Nascimento EJM, Nery N, Castanha PMS, Sacramento GA, Cruz J, Carvalho M, De Olivera D, Hagan JE, Adhikarla H, Wunder EA, Coêlho DF, Azar SR, Rossi SL, Vasilakis N, Weaver SC, Ribeiro GS, Balmaseda A, Harris E, Nogueira ML, Reis MG, Marques ETA, Cummings DAT, Ko AI. Impact of preexisting dengue immunity on Zika virus emergence in a dengue endemic region. Science 2019, 363: 607-610. PMID: 30733412, PMCID: PMC8221194, DOI: 10.1126/science.aav6618.Peer-Reviewed Original ResearchConceptsZika virusZIKV NS1 antigenAttack rateZika virus emergenceHigh antibody titersDengue-endemic regionsZIKV immunityClinical outcomesDengue immunityZIKV infectionAntibody titersNS1 antigenRisk factorsEndemic regionsDengue virusImmunityVirusRiskVirus emergenceFuture transmissionCohortSymptomsInfectionAntigenTiters
1999
Urban epidemic of severe leptospirosis in Brazil
Ko A, Reis M, Dourado C, Johnson W, Riley L, Group S. Urban epidemic of severe leptospirosis in Brazil. The Lancet 1999, 354: 820-825. PMID: 10485724, DOI: 10.1016/s0140-6736(99)80012-9.Peer-Reviewed Original ResearchConceptsDengue feverInfectious disease referral hospitalAggressive supportive careEpidemic of leptospirosisStrong independent predictorPositive blood culturesLarge urban outbreaksIdentification of leptospiresRenal insufficiencyRespiratory insufficiencySevere leptospirosisSupportive careIndependent predictorsReferral hospitalOutpatient clinicSevere anemiaSevere manifestationsActive surveillanceMental statusRisk factorsBlood culturesDiagnostic confusionUrban epidemicMicroagglutination testUrban outbreaks