2022
De novo emergence of a remdesivir resistance mutation during treatment of persistent SARS-CoV-2 infection in an immunocompromised patient: a case report
Gandhi S, Klein J, Robertson AJ, Peña-Hernández MA, Lin MJ, Roychoudhury P, Lu P, Fournier J, Ferguson D, Mohamed Bakhash SAK, Catherine Muenker M, Srivathsan A, Wunder EA, Kerantzas N, Wang W, Lindenbach B, Pyle A, Wilen CB, Ogbuagu O, Greninger AL, Iwasaki A, Schulz WL, Ko AI. De novo emergence of a remdesivir resistance mutation during treatment of persistent SARS-CoV-2 infection in an immunocompromised patient: a case report. Nature Communications 2022, 13: 1547. PMID: 35301314, PMCID: PMC8930970, DOI: 10.1038/s41467-022-29104-y.Peer-Reviewed Original ResearchConceptsSARS-CoV-2 infectionVirologic responsePersistent SARS-CoV-2 infectionResistance mutationsPre-treatment specimensB-cell deficiencyRemdesivir resistanceRemdesivir therapyViral sheddingCase reportAntiviral agentsPatientsCombinatorial therapyInfectionTherapyWhole-genome sequencingTreatmentImportance of monitoringDe novo emergenceFold increaseRNA-dependent RNA polymeraseNovo emergencePotential benefitsMutationsIndolent
1999
Randomized, Double-Blind Study of Stibogluconate Plus Human Granulocyte Macrophage Colony-Stimulating Factor versus Stibogluconate Alone in the Treatment of Cutaneous Leishmaniasis
Almeida R, D'Oliveira A, Machado P, Bacellar O, Ko A, de Jesus A, Mobashery N, Santos J, Carvalho E. Randomized, Double-Blind Study of Stibogluconate Plus Human Granulocyte Macrophage Colony-Stimulating Factor versus Stibogluconate Alone in the Treatment of Cutaneous Leishmaniasis. The Journal Of Infectious Diseases 1999, 180: 1735-1737. PMID: 10515844, DOI: 10.1086/315082.Peer-Reviewed Original ResearchConceptsCutaneous leishmaniasisGM-CSFDouble-blind placebo trialDouble-blind studyRecombinant human granulocyte-macrophage colony-stimulating factorGranulocyte macrophage-colony stimulating factorGM-CSF groupGranulocyte-macrophage colony-stimulating factorMacrophage-colony stimulating factorMacrophage colony-stimulating factorColony-stimulating factorHuman granulocyte macrophage-colony stimulating factorHuman granulocyte-macrophage colony-stimulating factorPlacebo groupPlacebo trialLesion healingSodium stibogluconatePatientsStibogluconateLeishmaniasisLesionsDaysTreatmentPlaceboGroup