Heterogeneous development of children with Congenital Zika Syndrome-associated microcephaly
Ticona J, Nery N, Doss-Gollin S, Gambrah C, Lessa M, Rastely-Júnior V, Matos A, de Paula Freitas B, Borja A, Wunder EA, Ballalai V, Vieira C, Cruz JS, de Oliveira D, Araujo DB, Oliveira DB, Maeda D, Mendes EA, Soares C, Durigon EL, de Souza Ferreira LC, Belfort R, Almeida A, Oliveira-Filho J, Reis MG, Ko AI, Costa F. Heterogeneous development of children with Congenital Zika Syndrome-associated microcephaly. PLOS ONE 2021, 16: e0256444. PMID: 34525107, PMCID: PMC8443077, DOI: 10.1371/journal.pone.0256444.Peer-Reviewed Original ResearchConceptsCongenital Zika syndromeHammersmith Infant Neurological ExaminationHINE scoresZika syndromeHead circumferenceBayley-IIILong-term outcomesGreater head circumferenceSevere developmental delayYears of ageSevere neurodevelopmental delayToddler neurodevelopmentNeurological evaluationMedian ageNeurodevelopmental outcomesNeurological examinationMultivariable analysisNeurodevelopmental assessmentOutpatient clinicNeurodevelopmental evaluationNeurodevelopmental delayBayley ScalesNeurodevelopmental profileSevere microcephalyMild delayDevelopmental outcomes in children exposed to Zika virus in utero from a Brazilian urban slum cohort study
Ticona J, Nery N, Ladines-Lim JB, Gambrah C, Sacramento G, de Paula Freitas B, Bouzon J, Oliveira-Filho J, Borja A, Adhikarla H, Montoya M, Chin A, Wunder EA, Ballalai V, Vieira C, Belfort R, Almeida A, Reis MG, Harris E, Ko AI, Costa F. Developmental outcomes in children exposed to Zika virus in utero from a Brazilian urban slum cohort study. PLOS Neglected Tropical Diseases 2021, 15: e0009162. PMID: 33544730, PMCID: PMC7891708, DOI: 10.1371/journal.pntd.0009162.Peer-Reviewed Original ResearchConceptsPopulation attributable fractionZIKV exposureMonths of ageMild cognitive delayZika virus exposureZIKV-exposed childrenPopulation-based cohortCognitive delayDevelopmental alterationsMonoclonal antibody blockadeMonths of lifeGross birth defectsAppropriate control groupsProspective serosurveyCohort studyNeurodevelopmental outcomesAntibody blockadeNeurodevelopmental evaluationVirus exposureAttributable fractionBehavioral abnormalitiesControl groupRest of womenZika virusCohort