Smooth Muscle Cell Tgf-β Receptor Knockout Improves Arteriovenous Fistula Maturation Via Attenuation of Autophagy
Zhang W, Bai H, Gonzalez L, Li Z, Ohashi Y, Thaxton C, Aoyagi Y, Yatsula B, Kano M, Xie Y, Cai Y, Chang S, Dardik A. Smooth Muscle Cell Tgf-β Receptor Knockout Improves Arteriovenous Fistula Maturation Via Attenuation of Autophagy. JVS Vascular Science 2024, 100222. DOI: 10.1016/j.jvssci.2024.100222.Peer-Reviewed Original ResearchReceptor knockoutAbstract 3092: Smooth Muscle Cell Tgf-β Receptor Knockout Improves Arteriovenous Fistula Maturation Via Attenuation Of Autophagy
Zhang W, Bai H, Gonzalez L, Li Z, Ohashi Y, Thaxton C, aoyagi Y, Yatsula B, Kano M, Xie Y, Cai Y, Chang S, Dardik A. Abstract 3092: Smooth Muscle Cell Tgf-β Receptor Knockout Improves Arteriovenous Fistula Maturation Via Attenuation Of Autophagy. Arteriosclerosis Thrombosis And Vascular Biology 2024, 44: a3092-a3092. DOI: 10.1161/atvb.44.suppl_1.3092.Peer-Reviewed Original ResearchChronic kidney diseaseSmooth muscle cellsEnd-stage renal diseaseArteriovenous fistulaHuman arteriovenous fistulaeControl miceC57BL/6J miceCKD showRate of primary failureBasilic vein transpositionTGF-bModel of arteriovenous fistulaTGF-b1 expressionArteriovenous fistula failureArteriovenous fistula maturationWild type miceControl C57BL/6J miceIncreased markers of autophagyTGF-b signalingVein transpositionAortocaval fistulaAVF maturationReceptor knockoutMT/mG miceSham nephrectomy