Abstract 3143: Computational Modeling Of Non-homeostatic Changes Within An Arterial-venous Fistula System Using In Vivo Validation To Understand Mechanical Causes Of Fistula Failure
Varsanik M, Thaxton C, Li W, Dardik A, Pocivavsek L. Abstract 3143: Computational Modeling Of Non-homeostatic Changes Within An Arterial-venous Fistula System Using In Vivo Validation To Understand Mechanical Causes Of Fistula Failure. Arteriosclerosis Thrombosis And Vascular Biology 2024, 44: a3143-a3143. DOI: 10.1161/atvb.44.suppl_1.3143.Peer-Reviewed Original ResearchArteriovenous fistulaFistula failureNeointimal hyperplasiaLong-term dialysis accessFistula systemClinical problemEnd stage renal patientsPresence of arteriovenous fistulaStatic pressureArteriovenous fistula failureCT angiography scansMurine AVF modelStenotic veinsVenous stenosisAngiography scansStatic pressure peakDialysis accessFistulaAnesthetized miceRenal patientsVenous velocityFistula modelIn vivo validationHigh static pressureNative veinsAbstract 1130: Tenascin-C In Arteriovenous Fistula Failure: Unraveling Venous Remodeling Dynamics
Gonzalez L, Zhang W, Ohashi Y, Vazquez-Padron R, Dardik A. Abstract 1130: Tenascin-C In Arteriovenous Fistula Failure: Unraveling Venous Remodeling Dynamics. Arteriosclerosis Thrombosis And Vascular Biology 2024, 44: a1130-a1130. DOI: 10.1161/atvb.44.suppl_1.1130.Peer-Reviewed Original ResearchHuman dermal microvascular endothelial cellsInferior vena cavaThrombomodulin expressionTNC expressionPost-AVF creationWild-type C57BL/6 miceMale wild-type C57BL/6 miceOne-year patency rateDecreased thrombomodulin expressionIncreased thrombomodulin expressionArteriovenous fistula failureTenascin-CSites of tissue injuryTranslational therapeutic strategiesDermal microvascular endothelial cellsNF-kB expressionMicrovascular endothelial cellsAVF patencyVena cavaAVF creationSham surgeryC57BL/6 miceFistula failureAVF failureSuperior patency