2021
Kynurenic acid may underlie sex-specific immune responses to COVID-19
Cai Y, Kim DJ, Takahashi T, Broadhurst DI, Yan H, Ma S, Rattray NJW, Casanovas-Massana A, Israelow B, Klein J, Lucas C, Mao T, Moore AJ, Muenker MC, Oh JE, Silva J, Wong P, team Y, Ko AI, Khan SA, Iwasaki A, Johnson CH. Kynurenic acid may underlie sex-specific immune responses to COVID-19. Science Signaling 2021, 14: eabf8483. PMID: 34230210, PMCID: PMC8432948, DOI: 10.1126/scisignal.abf8483.Peer-Reviewed Original ResearchConceptsKynurenic acidImmune responseClinical outcomesSex-specific immune responsesT cell responsesPoor clinical outcomeCOVID-19 patientsCoronavirus disease 2019COVID-19Sex-related differencesMale patientsCytokine abundanceInflammatory cytokinesKynurenine ratioSerum metabolomeDisease 2019Sex-specific linkKynurenine aminotransferaseCell responsesOld malePatientsMalesOutcomesResponseMetabolites
2020
Environmental Conditioning and Aerosol Infection of Mice.
Kudo E, Iwasaki A. Environmental Conditioning and Aerosol Infection of Mice. Bio-protocol 2020, 10: e3592. PMID: 33659558, PMCID: PMC7842367, DOI: 10.21769/bioprotoc.3592.Peer-Reviewed Original Research
2016
Antiviral responses of inbred mice
Iwasaki A. Antiviral responses of inbred mice. Nature Reviews Immunology 2016, 16: 339-339. PMID: 27108522, DOI: 10.1038/nri.2016.44.Peer-Reviewed Original Research
2007
Mucosal Dendritic Cells
Iwasaki A. Mucosal Dendritic Cells. Annual Review Of Immunology 2007, 25: 381-418. PMID: 17378762, DOI: 10.1146/annurev.immunol.25.022106.141634.Peer-Reviewed Original ResearchConceptsMucosal dendritic cellsDendritic cellsMucosal surfacesSpecialized dendritic cellsRobust protective immunityAdaptive immune systemMucus-secreting cellsProtective immunityEnvironmental antigensMucosal barrierCommensal floraImmune systemEpithelial cellsRecognition of microorganismsAntigenAppropriate local responsesCellsVital functionsResponsePathogensAbsence of pathogensExcretionImmunityInnate control of adaptive immunity: Dendritic cells and beyond
Lee HK, Iwasaki A. Innate control of adaptive immunity: Dendritic cells and beyond. Seminars In Immunology 2007, 19: 48-55. PMID: 17276695, DOI: 10.1016/j.smim.2006.12.001.Peer-Reviewed Original ResearchConceptsDendritic cellsAdaptive immune responsesImmune responseInnate immune recognitionKey cell typesCell typesEffector cellsNaïve lymphocytesAdaptive immunityInnate controlImmune recognitionAnatomical locationImmediate defensePathogen triggersCellsRecent understandingLymphocytesInfectionImmunityResponse
2004
Toll-like receptor control of the adaptive immune responses
Iwasaki A, Medzhitov R. Toll-like receptor control of the adaptive immune responses. Nature Immunology 2004, 5: 987-995. PMID: 15454922, DOI: 10.1038/ni1112.Peer-Reviewed Original ResearchConceptsToll-like receptorsAdaptive immune responsesImmune responseMechanisms of TLRToll-like receptor controlHost defense responsesDendritic cell functionDendritic cell populationsMicrobial infectionsInnate immune systemDistinct anatomical locationsInflammatory reactionAdaptive immunityImmune systemAnatomical locationReceptor controlCell functionCell populationsMultiple mechanismsInfectionRecent studiesResponseInitiationSystemic defenseImportant clues
1999
I. Mucosal dendritic cells: their specialized role in initiating T cell responses*
Iwasaki A, Kelsall B. I. Mucosal dendritic cells: their specialized role in initiating T cell responses*. American Journal Of Physiology 1999, 276: g1074-g1078. PMID: 10329996, DOI: 10.1152/ajpgi.1999.276.5.g1074.Peer-Reviewed Original ResearchConceptsT cell responsesMucosal dendritic cellsDendritic cellsCell responsesCompetent antigen-presenting cellsPrimary T cell responsesTissue-resident dendritic cellsResident dendritic cellsAntigen-presenting cellsDC populationsLymphoid tissueRecent studiesCellsFunctional studiesResponseMucosaIsolation procedureSpecialized roleEpitope-specific cytotoxic T lymphocyte induction by minigene DNA immunization
Iwasaki A, Dela Cruz C, Young A, Barber B. Epitope-specific cytotoxic T lymphocyte induction by minigene DNA immunization. Vaccine 1999, 17: 2081-2088. PMID: 10217610, DOI: 10.1016/s0264-410x(98)00411-3.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, ViralAntigen PresentationBiolisticsCytokinesEpitopes, T-LymphocyteFemaleGenes, ViralHistocompatibility Antigens Class IInjections, IntramuscularMiceMice, Inbred StrainsNucleocapsid ProteinsNucleoproteinsOrthomyxoviridaeOrthomyxoviridae InfectionsPeptide FragmentsPlasmidsProtein Sorting SignalsRecombinant ProteinsRNA-Binding ProteinsT-Lymphocytes, CytotoxicTumor Cells, CulturedVaccines, DNAViral Core ProteinsConceptsCTL responsesCytotoxic T lymphocyte inductionEpitope-specific CTL responsesT lymphocyte responsesT lymphocyte inductionPlasmid DNA vaccineFull-length antigenLymphocyte responsesIL-12Lymphocyte inductionAntibody responseDNA immunizationDNA vaccineGene gun bombardmentPotent antibodiesGM-CSFCytokine combinationsNeedle injectionInfluenza virusSkeletal muscleSkin epidermisNucleoproteinMinimal effectResponseImmunization