2024
Mediators of sex-specific differences in rates of stroke mimics among patients treated with intravenous thrombolysis: A nationwide analysis of 174,995 patients
Chen H, Khunte M, Colasurdo M, Chaturvedi S, Malhotra A, Gandhi D. Mediators of sex-specific differences in rates of stroke mimics among patients treated with intravenous thrombolysis: A nationwide analysis of 174,995 patients. Journal Of Stroke And Cerebrovascular Diseases 2024, 33: 108021. PMID: 39303869, DOI: 10.1016/j.jstrokecerebrovasdis.2024.108021.Peer-Reviewed Original ResearchRate of migraineNo cerebral infarctionPatients treated with intravenous thrombolysisRisk factorsIntravenous thrombolysisStroke mimicsMediation analysisICD-10 codesVascular risk factorsRetrospective cohort studyNational Inpatient Sample databaseIVT-treated patientsRates of stroke mimicsInpatient Sample databaseICD-10Cohort studyFemale patientsDemographic informationSex-specific differencesNationwide analysisCerebral infarctionPatientsSample databaseWomenMigrainePost-Thrombectomy Subarachnoid Hemorrhage: Incidence, Predictors, Clinical Relevance, and Effect Modulators
Chen H, Colasurdo M, Khunte M, Malhotra A, Gandhi D. Post-Thrombectomy Subarachnoid Hemorrhage: Incidence, Predictors, Clinical Relevance, and Effect Modulators. Diagnostics 2024, 14: 1856. PMID: 39272641, PMCID: PMC11394096, DOI: 10.3390/diagnostics14171856.Peer-Reviewed Original ResearchSubarachnoid hemorrhageIntraparenchymal hemorrhageAssociated with higher oddsEndovascular thrombectomyFemale sexAssociated with increased odds of in-hospital mortalityHospital outcomesHigher oddsNon-SAH groupSite of vascular occlusionOdds of in-hospital mortalityMultivariate logistic regression modelEndovascular thrombectomy patientsIn-hospital mortalityAssociated with increased oddsOdds of routine dischargeClinical detrimentRegression modelsLogistic regression modelsVascular occlusionSelf-careVessel occlusionPatientsSignificant predictorsHemorrhageRadiomics-Based Prediction of Collateral Status from CT Angiography of Patients Following a Large Vessel Occlusion Stroke
Avery E, Abou-Karam A, Abi-Fadel S, Behland J, Mak A, Haider S, Zeevi T, Sanelli P, Filippi C, Malhotra A, Matouk C, Falcone G, Petersen N, Sansing L, Sheth K, Payabvash S. Radiomics-Based Prediction of Collateral Status from CT Angiography of Patients Following a Large Vessel Occlusion Stroke. Diagnostics 2024, 14: 485. PMID: 38472957, PMCID: PMC10930945, DOI: 10.3390/diagnostics14050485.Peer-Reviewed Original ResearchCollateral statusCollateral scoreLarge vessel occlusionAcute LVO strokeRadiomics modelTest cohortCT angiography of patientsAdmission computed tomography angiographyAnterior circulation territoryAngiography of patientsLong-term outcomesReceiver operating characteristic areaRadiomics-based predictionCollateral arterial circulationOperating characteristics areaAdmission CTACirculation territoryCT angiographyClinical outcomesRadiomic featuresTreatment triageOcclusion strokeVessel occlusionPatientsArterial circulationUncertainty-aware deep-learning model for prediction of supratentorial hematoma expansion from admission non-contrast head computed tomography scan
Tran A, Zeevi T, Haider S, Abou Karam G, Berson E, Tharmaseelan H, Qureshi A, Sanelli P, Werring D, Malhotra A, Petersen N, de Havenon A, Falcone G, Sheth K, Payabvash S. Uncertainty-aware deep-learning model for prediction of supratentorial hematoma expansion from admission non-contrast head computed tomography scan. Npj Digital Medicine 2024, 7: 26. PMID: 38321131, PMCID: PMC10847454, DOI: 10.1038/s41746-024-01007-w.Peer-Reviewed Original ResearchDeep learning modelsHematoma expansionIntracerebral hemorrhageICH expansionComputed tomographyNon-contrast head CTNon-contrast head computed tomographyHigh risk of HEHead computed tomographyHigh-confidence predictionsRisk of HENon-contrast headReceiver operating characteristic areaModifiable risk factorsMonte Carlo dropoutOperating characteristics areaPotential treatment targetHead CTVisual markersIdentified patientsAutomated deep learning modelDataset of patientsRisk factorsHigh riskPatientsLetter to the Editor Re “Rethinking Cervical Spine Clearance in Obtunded Trauma Patients: An Updated Systematic Review and Meta-Analysis”.
Malhotra A, Wu X, Khunte M. Letter to the Editor Re “Rethinking Cervical Spine Clearance in Obtunded Trauma Patients: An Updated Systematic Review and Meta-Analysis”. Injury 2024, 55: 111359. PMID: 38262333, DOI: 10.1016/j.injury.2024.111359.Commentaries, Editorials and LettersTime-driven activity-based costing (TDABC) of direct-to-angiography pathway for acute ischemic stroke patients with suspected large vessel occlusion
Sangha K, White T, Boltyenkov A, Bastani M, Sanmartin M, Katz J, Malhotra A, Rula E, Naidich J, Sanelli P. Time-driven activity-based costing (TDABC) of direct-to-angiography pathway for acute ischemic stroke patients with suspected large vessel occlusion. Journal Of Stroke And Cerebrovascular Diseases 2024, 33: 107516. PMID: 38183964, DOI: 10.1016/j.jstrokecerebrovasdis.2023.107516.Peer-Reviewed Original ResearchAcute ischemic strokeEndovascular treatmentAcute ischemic stroke patientsAppropriate patient selection criteriaNovel care pathwayIschemic stroke patientsLarge vessel occlusionPatient selection criteriaInstitutional patient databaseTime-driven activity-based costingEligible patientsAnterior circulationIschemic strokeClinical outcomesPatient factorsStroke patientsAIS patientsVessel occlusionCare pathwayPatient costsMain cost driversPatientsPatient databaseAngiography suiteCT pathway
2023
Trends in Use of Intravenous Thrombolysis and Endovascular Thrombectomy in Patients With Acute Stroke With Large Vessel Occlusion 2016 to 2020 and Impact of COVID‐19 Pandemic
Khunte M, Chen H, Khunte A, Payabvash S, Gandhi D, Malhotra A. Trends in Use of Intravenous Thrombolysis and Endovascular Thrombectomy in Patients With Acute Stroke With Large Vessel Occlusion 2016 to 2020 and Impact of COVID‐19 Pandemic. Journal Of The American Heart Association 2023, 12: e029579. PMID: 37889182, PMCID: PMC10727381, DOI: 10.1161/jaha.122.029579.Peer-Reviewed Original ResearchUtility of Gadolinium-Based Contrast in Initial Evaluation of Seizures in Children Presenting Emergently
Andrijauskis D, Woolf G, Kuehne A, Al-Dasuqi K, Silva C, Payabvash S, Malhotra A. Utility of Gadolinium-Based Contrast in Initial Evaluation of Seizures in Children Presenting Emergently. American Journal Of Neuroradiology 2023, 44: 1208-1211. PMID: 37652579, PMCID: PMC10549952, DOI: 10.3174/ajnr.a7976.Peer-Reviewed Original ResearchConceptsSeizure presentationMR imagingConsecutive pediatric patientsNew-onset seizuresEvaluation of seizuresIschemic/hypoxicImaging of patientsBrain MR imagingGadolinium-based contrast agentsNoncontrast studyAcute onsetHippocampal sclerosisPediatric seizuresPatient agePediatric patientsNormal findingsIntracranial hemorrhageEmergency departmentVascular anomaliesInpatient unitGadolinium contrastPatientsNeurodevelopmental lesionAdditive benefitSeizuresO-007 Bridging thrombolysis yields diminished benefit among elderly stroke patients treated with endovascular thrombectomy
Chen H, Khunte M, Colasurdo M, Malhotra A, Gandhi D. O-007 Bridging thrombolysis yields diminished benefit among elderly stroke patients treated with endovascular thrombectomy. 2023, a6-a7. DOI: 10.1136/jnis-2023-snis.7.Peer-Reviewed Original ResearchCT With CTA Versus MRI in Patients Presenting to the Emergency Department With Dizziness: Analysis Using Propensity Score Matching.
Tu L, Navaratnam D, Melnick E, Forman H, Venkatesh A, Malhotra A, Yaesoubi R, Sureshanand S, Sheth K, Mahajan A. CT With CTA Versus MRI in Patients Presenting to the Emergency Department With Dizziness: Analysis Using Propensity Score Matching. American Journal Of Roentgenology 2023, 221: 836-845. PMID: 37404082, DOI: 10.2214/ajr.23.29617.Peer-Reviewed Original ResearchConceptsSecondary stroke prevention medicationsStroke prevention medicationsEmergency departmentPrevention medicationsEchocardiography evaluationPosterior circulation strokeProportion of patientsGroup of patientsPhysical examination findingsNeuroimaging resultsUse of MRIReview of systemsGreater frequencyPropensity-score matchingExamination findingsRetrospective studyED readmissionMedical historyHead CTClinical impactMRI examinationsBrain MRINeck CTADizzinessPatientsFactors associated with door-in-door-out times in large vessel occlusion stroke patients undergoing endovascular therapy
Radmard M, Wu X, Khunte M, Malhotra A. Factors associated with door-in-door-out times in large vessel occlusion stroke patients undergoing endovascular therapy. The American Journal Of Emergency Medicine 2023, 70: 192-193. PMID: 37393131, DOI: 10.1016/j.ajem.2023.06.020.Peer-Reviewed Original ResearchNational Trends of Cerebral Venous Sinus Stenting for the Treatment of Idiopathic Intracranial Hypertension
Khunte M, Chen H, Colasurdo M, Chaturvedi S, Malhotra A, Gandhi D. National Trends of Cerebral Venous Sinus Stenting for the Treatment of Idiopathic Intracranial Hypertension. Neurology 2023, 101: 402-406. PMID: 36990721, PMCID: PMC10501094, DOI: 10.1212/wnl.0000000000207245.Peer-Reviewed Original ResearchConceptsVenous sinus stentingOptic nerve sheath fenestrationIdiopathic intracranial hypertensionIIH treatmentCSF shuntsIntracranial hypertensionSurgical proceduresCerebral venous sinus stentingNational Inpatient Sample databaseStandard medical treatmentCerebral venous sinusesNew surgical procedureRecent temporal trendsAdult patientsSheath fenestrationSinus stentingHospital characteristicsPractice patternsVenous sinusesMedical treatmentComparative effectivenessProcedure numbersPatientsSample databaseShunt
2022
Letter to the editor re “Minor stroke in large vessel occlusion: A matched analysis of patients from the German Stroke Registry—Endovascular Treatment and patients from the Safe Implementation of Treatments in Stroke—International Stroke Thrombolysis Register”
Malhotra A, Khunte M, Wu X, Radmard M. Letter to the editor re “Minor stroke in large vessel occlusion: A matched analysis of patients from the German Stroke Registry—Endovascular Treatment and patients from the Safe Implementation of Treatments in Stroke—International Stroke Thrombolysis Register”. European Journal Of Neurology 2022, 30: 290-291. PMID: 36260371, DOI: 10.1111/ene.15598.Commentaries, Editorials and LettersEE47 Short-Term Cost-Effectiveness of Using Mobile Stroke Unit VS. Standard Ambulance for Patients with Suspected Stroke
Sangha K, White T, Malhotra A, Boltyenkov A, Katz J, Sanelli P. EE47 Short-Term Cost-Effectiveness of Using Mobile Stroke Unit VS. Standard Ambulance for Patients with Suspected Stroke. Value In Health 2022, 25: s344. DOI: 10.1016/j.jval.2022.04.301.Peer-Reviewed Original ResearchOptimizing Small, Low-Risk, Unruptured Intracranial Aneurysm Treatment Using Game Theory
Boltyenkov A, Wang J, Malhotra A, Katz J, Dehdashti A, White T, Martinez G, Pandya A, Sanelli P. Optimizing Small, Low-Risk, Unruptured Intracranial Aneurysm Treatment Using Game Theory. American Journal Of Neuroradiology 2022, 43: 176-180. PMID: 35027349, PMCID: PMC8985687, DOI: 10.3174/ajnr.a7392.Peer-Reviewed Original Research
2020
Letter regarding: “Elderly Patients With Cervical Spine Fractures After Ground Level Falls Are at Risk for Blunt Cerebrovascular Injury”
Malhotra A, Wu X, Khunte M. Letter regarding: “Elderly Patients With Cervical Spine Fractures After Ground Level Falls Are at Risk for Blunt Cerebrovascular Injury”. Journal Of Surgical Research 2020, 256: 696-697. PMID: 32861424, DOI: 10.1016/j.jss.2020.06.064.Peer-Reviewed Original ResearchReduced 2-year aneurysm retreatment and costs among patients treated with flow diversion versus non-flow diversion embolization: A Premier Healthcare Database retrospective cohort study
Grandhi R, Karsy M, Taussky P, Ricker CN, Malhotra A. Reduced 2-year aneurysm retreatment and costs among patients treated with flow diversion versus non-flow diversion embolization: A Premier Healthcare Database retrospective cohort study. PLOS ONE 2020, 15: e0234478. PMID: 32555657, PMCID: PMC7302520, DOI: 10.1371/journal.pone.0234478.Peer-Reviewed Original ResearchConceptsPipeline Embolization DeviceEndovascular treatmentRetreatment ratePS matchingIntracranial aneurysmsRetrospective cohort studyRate of readmissionEmergency department visitsLength of stayLower retreatment rateInitial treatment costsUnruptured intracranial aneurysmsPropensity-score matchingTime of treatmentCumulative followCohort studyReadmission costsDepartment visitsPatient subgroupsPED placementCase selection biasSame hospitalAneurysm retreatmentEmbolization DevicePatientsUtility of routine follow-up imaging in patients with small paraflacine and/or paratentorial hemorrhages
Seifert KD, Wu X, Malhotra A. Utility of routine follow-up imaging in patients with small paraflacine and/or paratentorial hemorrhages. Clinical Neurology And Neurosurgery 2020, 196: 105956. PMID: 32526488, DOI: 10.1016/j.clineuro.2020.105956.Peer-Reviewed Original ResearchConceptsSubdural hemorrhageRoutine follow-up imagingSubsequent imagingImaging studiesSecond imaging studyAbsence of anticoagulationSubsequent imaging studiesFollow-up imagingAcute intracranial hemorrhageAnticoagulation useStable patientsRetrospective reviewClinical progressionIntracranial hemorrhageEmergency departmentClinical dataHemorrhage sizeHemorrhageRoutine imagingPatient statusPatientsParafalcineMultiple followSame protocolAverage numberImplications of achieving TICI 2b vs TICI 3 reperfusion in patients with ischemic stroke: a cost-effectiveness analysis
Wu X, Khunte M, Gandhi D, Matouk C, Hughes DR, Sanelli P, Malhotra A. Implications of achieving TICI 2b vs TICI 3 reperfusion in patients with ischemic stroke: a cost-effectiveness analysis. Journal Of NeuroInterventional Surgery 2020, 12: 1161-1165. PMID: 32457225, DOI: 10.1136/neurintsurg-2020-015873.Peer-Reviewed Original ResearchConceptsQuality-adjusted life yearsLarge vessel occlusionTICI 3 reperfusionEndovascular thrombectomyTICI 2bTICI 3Stroke patientsHealth benefitsAge groupsAcute stroke patientsDegree of recanalizationDegree of reperfusionLifetime quality-adjusted life yearsCost-effectiveness analysisDecision analytic studyUnited States settingsIncomplete reperfusionIschemic strokeComplete reperfusionPatient selectionReperfusionPatientsHealth outcomesLife yearsCost savingsDiagnostic Value of CT of Chest, Abdomen, and Pelvis in Patients With Solitary and Multiple Brain Lesions.
Rothman RK, Weinreb J, Zucconi W, Malhotra A. Diagnostic Value of CT of Chest, Abdomen, and Pelvis in Patients With Solitary and Multiple Brain Lesions. American Journal Of Roentgenology 2020, 214: 636-640. PMID: 31939701, DOI: 10.2214/ajr.19.22051.Peer-Reviewed Original ResearchConceptsPrimary neoplasmsBrain lesionsChest CTIntracranial lesionsCT CAPAncillary signsBrain neoplasmsNew intracranial lesionsPrimary brain neoplasmsMultiple brain lesionsMalignant brain neoplasmsLarge academic hospitalPresence of enhancementBrain metastasesLung primaryMetastatic workupSuch patientsPrimary cancerLesion characteristicsAcademic hospitalBenign entityCT scanPatientsMalignant casesNeoplasms