2013
Recruitment of folliculin to lysosomes supports the amino acid–dependent activation of Rag GTPases
Petit CS, Roczniak-Ferguson A, Ferguson SM. Recruitment of folliculin to lysosomes supports the amino acid–dependent activation of Rag GTPases. Journal Of Cell Biology 2013, 202: 1107-1122. PMID: 24081491, PMCID: PMC3787382, DOI: 10.1083/jcb.201307084.Peer-Reviewed Original ResearchMeSH KeywordsAmino AcidsBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsBlotting, WesternCarrier ProteinsCytoplasmFluorescent Antibody TechniqueHumansImmunoprecipitationLysosomesMechanistic Target of Rapamycin Complex 1Monomeric GTP-Binding ProteinsMultiprotein ComplexesProto-Oncogene ProteinsRecombinant ProteinsRNA, Small InterferingTOR Serine-Threonine KinasesTumor Suppressor ProteinsConceptsAmino acid-dependent activationAcid-dependent activationTranscription factor EBRag GTPasesSurface of lysosomesMTORC1-dependent phosphorylationAmino acid depletionLysosome recruitmentGTPase domainRAG interactionsCytoplasmic sequestrationLysosome functionGTPasesFLCNHuman diseasesFunction mutationsDevelopment of pneumothoraxProtein 1Direct interactionLysosomesCritical rolePulmonary cystsSite of actionAcid depletionFolliculin gene
1996
Immortalized rabbit cortical collecting duct cells express AT1 angiotensin II receptors
Burns K, Regnier L, Roczniak A, Hebert R. Immortalized rabbit cortical collecting duct cells express AT1 angiotensin II receptors. American Journal Of Physiology 1996, 271: f1147-f1157. PMID: 8997388, DOI: 10.1152/ajprenal.1996.271.6.f1147.Peer-Reviewed Original ResearchMeSH KeywordsAngiotensin IIAnimalsAntigens, Polyomavirus TransformingArginine VasopressinBiological TransportCell Line, TransformedCyclic AMPFemaleFluorescent Antibody TechniqueHydrolysisKidney CortexKidney Tubules, CollectingMicroscopy, Electron, ScanningPhosphatidylinositolsRabbitsReceptors, AngiotensinSimian virus 40TransfectionConceptsCortical collecting ductAng IIArginine vasopressinAT1 receptorAntibodies to smooth muscle myosinInhibit AVP-stimulated cAMP productionStimulate adenosine 3',5'-cyclic monophosphateAVP-stimulated cAMP productionEpithelial cell marker cytokeratinRabbit cortical collecting ductTransfected cellsEffects of Ang IITransepithelial short-circuit currentAT1 receptor mRNAStudy angiotensin IIAlpha-intercalated cellsAdenosine 3',5'-cyclic monophosphateAng II receptorsStimulation of phosphoinositide turnoverIncreased phosphoinositide hydrolysisInhibition of cAMPPeanut lectin agglutininRadioligand binding assaysTamm-Horsfall proteinSmooth muscle myosin