Pleiotropic requirements for human TDP-43 in the regulation of cell and organelle homeostasis
Roczniak-Ferguson A, Ferguson SM. Pleiotropic requirements for human TDP-43 in the regulation of cell and organelle homeostasis. Life Science Alliance 2019, 2: e201900358. PMID: 31527135, PMCID: PMC6749094, DOI: 10.26508/lsa.201900358.Peer-Reviewed Original ResearchConceptsMultiple amyotrophic lateral sclerosisTDP-43 target genesNormal TDP-43 functionSpecific target transcriptsCell biological consequencesRNA-binding proteinTDP-43Disease-causing mutantsRegulation of cellPleiotropic requirementMultiple neurodegenerative diseasesOrganelle homeostasisTarget transcriptsMRNA splicingKnockout cellsTranscriptomic analysisMultiple organellesTDP-43 functionTarget genesCytoplasmic aggregatesNuclear envelopeTDP-43 mutationsTDP-43 depletionHuman TDP-43Morphological defects