80. IMPLICATION OF COMPLEX STRUCTURAL GENOME VARIATION IN THE GENETIC ARCHITECTURE OF NEUROPSYCHIATRIC DISORDERS: INSIGHTS FROM HUMAN POPULATION ANALYSIS AND FROM POSTMORTEM BRAINS OF INDIVIDUALS WITH PSYCHIATRIC DISORDERS
Zhou B, Arthur J, Guo H, Kim T, Huang Y, Pattni R, Song G, Palejev D, Dohna H, Roussos P, Kundaje A, Hallmayer J, Snyder M, Wong, Urban A. 80. IMPLICATION OF COMPLEX STRUCTURAL GENOME VARIATION IN THE GENETIC ARCHITECTURE OF NEUROPSYCHIATRIC DISORDERS: INSIGHTS FROM HUMAN POPULATION ANALYSIS AND FROM POSTMORTEM BRAINS OF INDIVIDUALS WITH PSYCHIATRIC DISORDERS. European Neuropsychopharmacology 2024, 87: 93. DOI: 10.1016/j.euroneuro.2024.08.194.Peer-Reviewed Original ResearchWhole-genome sequencingComplex structural variationsHuman genomeMarker SNPsContinental populationsRisk allelesShort-read whole-genome sequencingSingle-nuclei RNA-seqFunctional genomics dataComplex genetic architectureDNA sequence variantsComplex genetic componentPost-mortem brainsPopulation-scale studiesDifferentially expressed genesVariant typeIntegration of genotypesStructural variationsGWAS lociGenome biologyCandidate lociIndividual genomesLinkage analysisGenomic analysisGenomic data