2014
Comparison of oral amoxicillin given thrice or twice daily to children between 2 and 59 months old with non-severe pneumonia: a randomized controlled trial
Vilas-Boas A, Fontoura M, Xavier-Souza G, Araújo-Neto C, Andrade S, Brim R, Noblat L, Barral A, Cardoso M, Nascimento-Carvalho C, Matutino A, Barreto B, Silva C, Braga D, Oliveira F, Nogueira G, Oliveira Í, Lorgetto I, Costa I, Araripe J, Vieira J, Neiva L, Santana M, Nobre-Bastos M, Santos P, Câmara S, Carneiro S, Sirmos U, Araújo V, Silva C, Vilas-Boas C, Gantois D, Azevedo F, Maia J, Pirajá L, Jesus P, Fonseca T, Vilar T. Comparison of oral amoxicillin given thrice or twice daily to children between 2 and 59 months old with non-severe pneumonia: a randomized controlled trial. Journal Of Antimicrobial Chemotherapy 2014, 69: 1954-1959. PMID: 24648506, DOI: 10.1093/jac/dku070.Peer-Reviewed Original ResearchConceptsNon-severe pneumoniaTreatment failureOral amoxicillinFirst-line therapyChildhood pneumoniaPrimary outcomeTreat analysisRespiratory complaintsBlinded investigationDaily dosesChest radiographsPatient allocationPneumoniaPatientsIndependent radiologistsAmoxicillinProtocol analysisThriceMonthsChildrenParticipantsFailureConcordant readingsPlaceboTherapy
2010
Clinical failure among children with nonsevere community-acquired pneumonia treated with amoxicillin
Fontoura M, Araújo-Neto C, Andrade S, Brim R, Matutino A, Silva C, Santana M, Nobre-Bastos M, Oliveira F, Barreto B, Santos P, Noblat L, Cardoso M, Nascimento-Carvalho C, Group T. Clinical failure among children with nonsevere community-acquired pneumonia treated with amoxicillin. Expert Opinion On Pharmacotherapy 2010, 11: 1451-1458. PMID: 20408745, DOI: 10.1517/14656561003777034.Peer-Reviewed Original ResearchConceptsClinical failureDays of treatmentRisk factorsNonsevere community-acquired pneumoniaAdverse effect frequencyPersistence of feverRadiographic pulmonary infiltratesCommunity-acquired pneumoniaIndependent risk factorClinical failure rateNonsevere pneumoniaPulmonary infiltratesAdverse eventsPleural effusionRespiratory complaintsClinical findingsDifficulty breathingAdverse reactionsSevere diseasePneumonia diagnosisCystic fibrosisMultivariate analysisDemographic dataAmoxicillinOlder children