2005
Glutathione protects human airway proteins and epithelial cells from isocyanates
Wisnewski AV, Liu Q, Liu J, Redlich CA. Glutathione protects human airway proteins and epithelial cells from isocyanates. Clinical & Experimental Allergy 2005, 35: 352-357. PMID: 15784115, DOI: 10.1111/j.1365-2222.2005.02185.x.Peer-Reviewed Original ResearchConceptsDose-dependent mannerAirway fluidGSH levelsHuman airway epithelial cellsVapor exposure systemEpithelial cellsHuman airway epithelial cell lineAirway epithelial cell lineEpithelial lining fluidAirway epithelial cellsEpithelial cell exposureEpithelial cell toxicityAllergic sensitizationEpithelial cell lineHDI exposureAirway proteinsLining fluidAirway cellsIsocyanate exposureVivo exposureOccupational limitsNCI-H292Physiologic levelsEpithelial fluidToxicity studies
2003
Human γ/δ T-cell proliferation and IFN-γ production induced by hexamethylene diisocyanate
Wisnewski AV, Herrick CA, Liu Q, Chen L, Bottomly K, Redlich CA. Human γ/δ T-cell proliferation and IFN-γ production induced by hexamethylene diisocyanate. Journal Of Allergy And Clinical Immunology 2003, 112: 538-546. PMID: 13679813, DOI: 10.1016/s0091-6749(03)01865-7.Peer-Reviewed Original ResearchConceptsGamma/delta T cellsDelta T cellsHuman immune responseT cellsT cell receptorImmune responseAlpha/beta T cell receptorBeta T cell receptorHuman airway epithelial cellsIFN-γ productionGamma/deltaT cell proliferationAirway epithelial cellsHuman T cell lineT cell linesHuman T cellsCell typesOccupational asthmaCytokine productionPeripheral bloodIL-13IL-5Antigen-mediated selectionAntigen leadIFN-gamma
2001
Human γ / δ T-Cell Lines Derived from Airway Biopsies
Wisnewski A, Cain H, Magoski N, Wang H, Holm C, Redlich C. Human γ / δ T-Cell Lines Derived from Airway Biopsies. American Journal Of Respiratory Cell And Molecular Biology 2001, 24: 332-338. PMID: 11245633, DOI: 10.1165/ajrcmb.24.3.4325.Peer-Reviewed Original ResearchConceptsGamma/delta T cellsDelta T cellsT cell linesT cell receptorT cellsTetanus toxoidAirway biopsiesPeripheral bloodGamma/delta T cell linesGamma/delta T cell receptorBlood-derived T cellsDelta T-cell receptorDifferent T cell receptorsAirway T cellsLike cytokine profileAntigen-dependent proliferationT helper 1Human airway tissuePeripheral blood samplesHuman lung tissueHuman airway biopsiesCytokine profileAirway tissueHelper 1Lung tissue
1999
A Human Anti-HIV Autoantibody Enhances EBV Transformation and HIV Infection
Cavacini L, Wisnewski A, Peterson J, Montefiori D, Emes C, Duval M, Kingsbury G, Wang A, Scadden D, Posner M. A Human Anti-HIV Autoantibody Enhances EBV Transformation and HIV Infection. Clinical Immunology 1999, 93: 263-273. PMID: 10600338, DOI: 10.1006/clim.1999.4790.Peer-Reviewed Original ResearchConceptsUninfected lymphoid cellsLymphoid cellsEBV transformationB cellsHIV-1-infected cellsHIV-1 infectionComplement-dependent mannerCross-reactive natureB cell proliferationNormal B cellsHIV infectionHIV pathogenesisNK cellsAntibody responseFree gp120Immunoglobulin productionT cellsHIV-1Human mAbsViral infectionVH3 family genesIgG mAbsHuman IgG mAbsUninfected cellsInfection