2024
Lung Gene Expression Suggests Roles for Interferon-Stimulated Genes and Adenosine Deaminase Acting against RNA‑1 in Pathologic Responses to Diisocyanate
Wisnewski A, Liu J. Lung Gene Expression Suggests Roles for Interferon-Stimulated Genes and Adenosine Deaminase Acting against RNA‑1 in Pathologic Responses to Diisocyanate. Chemical Research In Toxicology 2024, 37: 476-485. PMID: 38494904, DOI: 10.1021/acs.chemrestox.3c00325.Peer-Reviewed Original ResearchLung gene expressionNonsensitized miceImmune-sensitizationType I interferon-stimulated genesI interferon-stimulated genesAllergen-induced asthmaChemical-induced asthmaMolecular pathwaysADAR-1Ovalbumin-induced asthmaRegulation of innateInterferon-stimulated genesGene transcriptionGene expressionPathological responseAdenosine Deaminase ActingMurine modelAsthma-likeNonsensitized hostsLevels up to 10-foldLung tissueInnate responseLungTissue damageMice
2011
Immune sensitization to methylene diphenyl diisocyanate (MDI) resulting from skin exposure: albumin as a carrier protein connecting skin exposure to subsequent respiratory responses
Wisnewski AV, Xu L, Robinson E, Liu J, Redlich CA, Herrick CA. Immune sensitization to methylene diphenyl diisocyanate (MDI) resulting from skin exposure: albumin as a carrier protein connecting skin exposure to subsequent respiratory responses. Journal Of Occupational Medicine And Toxicology 2011, 6: 6. PMID: 21414210, PMCID: PMC3068988, DOI: 10.1186/1745-6673-6-6.Peer-Reviewed Original ResearchRespiratory tract inflammationImmune sensitizationSkin exposureMDI conjugationBronchoalveolar lavageInflammatory responseRespiratory tract exposureAirway inflammatory responseAcetone/olive oilSubsequent immune responseSpecific antibody productionDisease prevention effortsAlbumin conjugatesOccupational asthmaSerum levelsMDI exposureAsthma pathogenesisSerum IgGIntranasal deliveryImmune responseImmune sensitivityMurine modelPathogenic mechanismsInflammationAntibody production