2011
Central and Peripheral Administration of Compound 21 Elicits Cerebroprotective Effects in Ischemic Stroke
Joseph J, Regenhardt R, Mecca A, Patel N, Steckelings U, Unger T, Katovich M, Sumners C. Central and Peripheral Administration of Compound 21 Elicits Cerebroprotective Effects in Ischemic Stroke. The FASEB Journal 2011, 25: lb576-lb576. DOI: 10.1096/fasebj.25.1_supplement.lb576.Peer-Reviewed Original ResearchMiddle cerebral artery occlusionIpsilateral gray matterArtificial cerebrospinal fluidInfarct sizeMCAO inductionIschemic strokeNeurological deficitsControl ratsAdult male Sprague-Dawley ratsAngiotensin type 2 receptorGray matterMale Sprague-Dawley ratsSpecific AT2R agonistCerebral artery occlusionExert beneficial actionsSprague-Dawley ratsType 2 receptorACSF controlsCerebroprotective effectArtery occlusionPeripheral administrationAT2R agonistIP administrationEndothelin-1Intracerebroventricular infusion
2007
Angiotensin‐(1–7) prevents cardiac remodeling during angiotensin II‐induced hypertension
Grobe J, Mecca A, Lingis M, Shenoy V, Bolton T, Machado J, Speth R, Raizada M, Katovich M. Angiotensin‐(1–7) prevents cardiac remodeling during angiotensin II‐induced hypertension. The FASEB Journal 2007, 21: a896-a897. DOI: 10.1096/fasebj.21.6.a896-d.Peer-Reviewed Original ResearchAng IICardiac remodelingBlood pressureInterstitial fibrosisMyocyte hypertrophyMale Sprague-Dawley ratsAng II infusionAnti-remodeling effectsEnd-organ damageRenin-angiotensin systemSprague-Dawley ratsII infusionAng receptorsAngiotensin receptorsAngiotensin IIMyocardial fibrosisRat modelMyocyte diameterEnzyme 2Receptor populationAngHypertensionFibrosisSignificant attenuationLentiviral delivery