Candesartan pretreatment is cerebroprotective in a rat model of endothelin‐1‐induced middle cerebral artery occlusion
Mecca AP, O'Connor TE, Katovich MJ, Sumners C. Candesartan pretreatment is cerebroprotective in a rat model of endothelin‐1‐induced middle cerebral artery occlusion. Quarterly Journal Of Experimental Physiology And Cognate Medical Sciences 2009, 94: 937-946. PMID: 19429641, PMCID: PMC2742297, DOI: 10.1113/expphysiol.2009.047936.Peer-Reviewed Original ResearchConceptsAng II type 1 receptor blockerIschemic strokeEndothelin-1-induced middle cerebral artery occlusionMiddle cerebral artery occlusion modelBrain renin-angiotensin systemType 1 receptor blockerMiddle cerebral artery occlusionIpsilateral gray matterCerebral artery occlusionRenin-angiotensin systemArtery occlusion modelAnimal stroke modelsSignificant neurological impairmentCandesartan pretreatmentCerebroprotective propertiesGradual reperfusionEmbolic strokeArtery occlusionNeurological deficitsReceptor blockersSystemic pretreatmentBlood pressureCerebral ischaemiaMCAO modelInfarct size