2011
Central and Peripheral Administration of Compound 21 Elicits Cerebroprotective Effects in Ischemic Stroke
Joseph J, Regenhardt R, Mecca A, Patel N, Steckelings U, Unger T, Katovich M, Sumners C. Central and Peripheral Administration of Compound 21 Elicits Cerebroprotective Effects in Ischemic Stroke. The FASEB Journal 2011, 25: lb576-lb576. DOI: 10.1096/fasebj.25.1_supplement.lb576.Peer-Reviewed Original ResearchMiddle cerebral artery occlusionIpsilateral gray matterArtificial cerebrospinal fluidInfarct sizeMCAO inductionIschemic strokeNeurological deficitsControl ratsAdult male Sprague-Dawley ratsAngiotensin type 2 receptorGray matterMale Sprague-Dawley ratsSpecific AT2R agonistCerebral artery occlusionExert beneficial actionsSprague-Dawley ratsType 2 receptorACSF controlsCerebroprotective effectArtery occlusionPeripheral administrationAT2R agonistIP administrationEndothelin-1Intracerebroventricular infusion
2009
Cerebroprotective action of angiotensin 1‐7 in a rat model of ischemic stroke
Mecca A, O'Connor T, Dooies K, Katovich M, Sumners C. Cerebroprotective action of angiotensin 1‐7 in a rat model of ischemic stroke. The FASEB Journal 2009, 23: 947.1-947.1. DOI: 10.1096/fasebj.23.1_supplement.947.1.Peer-Reviewed Original ResearchMiddle cerebral artery occlusionAngiotensin-Converting Enzyme 2Ang-1Artificial cerebrospinal fluidControl ratsIschemic strokeNeurological deficitsInfarct sizeAngiotensin 1Rat modelArtificial cerebrospinal fluid controlsIpsilateral gray matterCerebral artery occlusionLateral ventricular cannulasConverting enzyme 2Cerebrospinal fluid controlsCerebroprotective propertiesMCAO inductionArtery occlusionCerebroprotective actionEndothelin-1Ventricular cannulaEnzyme 2Cerebrospinal fluidET-1
2005
Protection from angiotensin II‐induced cardiac hypertrophy and fibrosis by systemic lentiviral delivery of ACE2 in rats
Huentelman MJ, Grobe JL, Vazquez J, Stewart JM, Mecca AP, Katovich MJ, Ferrario CM, Raizada MK. Protection from angiotensin II‐induced cardiac hypertrophy and fibrosis by systemic lentiviral delivery of ACE2 in rats. Quarterly Journal Of Experimental Physiology And Cognate Medical Sciences 2005, 90: 783-790. PMID: 16049057, DOI: 10.1113/expphysiol.2005.031096.Peer-Reviewed Original ResearchMeSH KeywordsAngiotensin IIAngiotensin-Converting Enzyme 2AnimalsAnimals, NewbornBlood PressureBody WeightCarboxypeptidasesCardiomyopathy, HypertrophicEndomyocardial FibrosisGene ExpressionGenetic VectorsHeartLentivirusMiceMyocardiumOrgan SizePeptidyl-Dipeptidase ARatsRats, Sprague-DawleyTransduction, GeneticConceptsRenin-angiotensin systemAngiotensin IIMyocardial fibrosisCardiac hypertrophyAngiotensin II infusionSystolic blood pressureBody weight ratioOverexpression of ACE2Potential therapeutic targetII infusionMmHg increaseBlood pressureHeart weightControl ratsDawley ratsCardiovascular diseaseEnzyme 2Protective effectTherapeutic targetMouse ACE2FibrosisHypertrophyRatsACE2Significant attenuation