2011
Cerebroprotection by angiotensin‐(1–7) in endothelin‐1‐induced ischaemic stroke
Mecca AP, Regenhardt RW, O’Connor T, Joseph JP, Raizada MK, Katovich MJ, Sumners C. Cerebroprotection by angiotensin‐(1–7) in endothelin‐1‐induced ischaemic stroke. Quarterly Journal Of Experimental Physiology And Cognate Medical Sciences 2011, 96: 1084-1096. PMID: 21685445, PMCID: PMC3210510, DOI: 10.1113/expphysiol.2011.058578.Peer-Reviewed Original ResearchMeSH KeywordsAngiotensin IAngiotensin IIAngiotensin-Converting Enzyme 2AnimalsDiminazeneEndothelin-1Enzyme ActivationInfarction, Middle Cerebral ArteryMaleNitric Oxide Synthase Type IIPeptide FragmentsPeptidyl-Dipeptidase AProto-Oncogene MasProto-Oncogene ProteinsRatsRats, Sprague-DawleyReceptors, G-Protein-CoupledStrokeConceptsMiddle cerebral artery occlusionIschemic strokeDiminazine aceturateNeurological deficitsBeneficial actionsInducible nitric oxide synthase (iNOS) expressionInducible nitric oxide synthase (iNOS) mRNA expressionNitric oxide synthase mRNA expressionNitric oxide synthase expressionCerebral infarct sizeCerebral artery occlusionCerebral ischemic strokeOxide synthase expressionCerebral blood flowExert beneficial actionsType 1 receptorActivation of angiotensinSynthase mRNA expressionACE2 activatorACE2-AngCerebroprotective propertiesDIZE treatmentCerebral infarctsProduction of angiotensinArtery occlusion
2009
Candesartan pretreatment is cerebroprotective in a rat model of endothelin‐1‐induced middle cerebral artery occlusion
Mecca AP, O'Connor TE, Katovich MJ, Sumners C. Candesartan pretreatment is cerebroprotective in a rat model of endothelin‐1‐induced middle cerebral artery occlusion. Quarterly Journal Of Experimental Physiology And Cognate Medical Sciences 2009, 94: 937-946. PMID: 19429641, PMCID: PMC2742297, DOI: 10.1113/expphysiol.2009.047936.Peer-Reviewed Original ResearchConceptsAng II type 1 receptor blockerIschemic strokeEndothelin-1-induced middle cerebral artery occlusionMiddle cerebral artery occlusion modelBrain renin-angiotensin systemType 1 receptor blockerMiddle cerebral artery occlusionIpsilateral gray matterCerebral artery occlusionRenin-angiotensin systemArtery occlusion modelAnimal stroke modelsSignificant neurological impairmentCandesartan pretreatmentCerebroprotective propertiesGradual reperfusionEmbolic strokeArtery occlusionNeurological deficitsReceptor blockersSystemic pretreatmentBlood pressureCerebral ischaemiaMCAO modelInfarct sizeCerebroprotective action of angiotensin 1‐7 in a rat model of ischemic stroke
Mecca A, O'Connor T, Dooies K, Katovich M, Sumners C. Cerebroprotective action of angiotensin 1‐7 in a rat model of ischemic stroke. The FASEB Journal 2009, 23: 947.1-947.1. DOI: 10.1096/fasebj.23.1_supplement.947.1.Peer-Reviewed Original ResearchMiddle cerebral artery occlusionAngiotensin-Converting Enzyme 2Ang-1Artificial cerebrospinal fluidControl ratsIschemic strokeNeurological deficitsInfarct sizeAngiotensin 1Rat modelArtificial cerebrospinal fluid controlsIpsilateral gray matterCerebral artery occlusionLateral ventricular cannulasConverting enzyme 2Cerebrospinal fluid controlsCerebroprotective propertiesMCAO inductionArtery occlusionCerebroprotective actionEndothelin-1Ventricular cannulaEnzyme 2Cerebrospinal fluidET-1