Featured Publications
Excess Cerebrovascular Mortality in the United States During the COVID-19 Pandemic
Sharma R, Kuohn LR, Weinberger DM, Warren JL, Sansing LH, Jasne A, Falcone G, Dhand A, Sheth KN. Excess Cerebrovascular Mortality in the United States During the COVID-19 Pandemic. Stroke 2021, 52: 563-572. PMID: 33430638, PMCID: PMC7834664, DOI: 10.1161/strokeaha.120.031975.Peer-Reviewed Original ResearchConceptsEmergency medical servicesCerebrovascular deathCOVID-19 deathsCerebrovascular mortalityCOVID-19 pandemicStroke-related deathCoronavirus disease 2019 (COVID-19) pandemicFirst COVID-19 deathDisease 2019 pandemicPublic health measuresHealth Statistics dataPoisson regression modelsCumulative COVID-19 deathsAcute strokeStroke deathsVascular pathologyEMS callsMedical careHealth measuresNew York CityMortalityDeathMedical servicesWeeksRegression analysisCerebellar Hippocampal and Basal Nuclei Transient Edema with Restricted diffusion (CHANTER) Syndrome
Jasne AS, Alsherbini KH, Smith MS, Pandhi A, Vagal A, Kanter D. Cerebellar Hippocampal and Basal Nuclei Transient Edema with Restricted diffusion (CHANTER) Syndrome. Neurocritical Care 2019, 31: 288-296. PMID: 30788708, PMCID: PMC6757017, DOI: 10.1007/s12028-018-00666-4.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlcoholic IntoxicationAmphetaminesBasal GangliaBenzodiazepinesBrain EdemaCentral Nervous System StimulantsCerebellar CortexCerebellumCocaineComaFemaleHeroinHippocampusHumansHydrocephalusHydromorphoneMagnetic Resonance ImagingMaleMiddle AgedOpiate AlkaloidsPain, PostoperativeStuporSubstance-Related DisordersSyndromeConceptsCerebellar edemaIschemic strokeObstructive hydrocephalusCerebellar cortexAcute cytotoxic edemaSeries of patientsNeurocritical care unitPatterns of injuryLevel of consciousnessMagnetic resonance imagingClinical characteristicsInitial presentationCare unitSurgical managementHypoxic injuryCytotoxic edemaFavorable outcomeSimilar presentationAnoxic injuryBilateral hippocampusTransient edemaBasal nucleusToxic injuryNovel syndromeAcceptable outcomesStroke Code Presentations, Interventions, and Outcomes Before and During the COVID-19 Pandemic
Jasne AS, Chojecka P, Maran I, Mageid R, Eldokmak M, Zhang Q, Nystrom K, Vlieks K, Askenase M, Petersen N, Falcone GJ, Wira CR, Lleva P, Zeevi N, Narula R, Amin H, Navaratnam D, Loomis C, Hwang DY, Schindler J, Hebert R, Matouk C, Krumholz HM, Spudich S, Sheth KN, Sansing LH, Sharma R. Stroke Code Presentations, Interventions, and Outcomes Before and During the COVID-19 Pandemic. Stroke 2020, 51: 2664-2673. PMID: 32755347, PMCID: PMC7446978, DOI: 10.1161/str.0000000000000347.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overBetacoronavirusBrain IschemiaCohort StudiesComorbidityConnecticutCoronary Artery DiseaseCoronavirus InfectionsCOVID-19DyslipidemiasEmergency Medical ServicesEthnicityFemaleHumansHypertensionIncomeInsurance, HealthIntracranial HemorrhagesMaleMedically UninsuredMiddle AgedOutcome and Process Assessment, Health CarePandemicsPneumonia, ViralRetrospective StudiesSARS-CoV-2Severity of Illness IndexStrokeSubstance-Related DisordersTelemedicineThrombectomyThrombolytic TherapyTime-to-TreatmentConceptsComprehensive stroke centerStroke codePatient characteristicsStroke severityStroke code patientsHistory of hypertensionStroke-like symptomsCoronary artery diseaseCoronavirus disease 2019 (COVID-19) pandemicPatient-level dataLower median household incomePublic health initiativesDisease 2019 pandemicCOVID-19 pandemicRace/ethnicityCode patientsHospital presentationPublic health insuranceRankin ScaleStroke centersArtery diseaseReperfusion timeStroke symptomsEarly outcomesConnecticut hospitals
2024
Stroke and COVID
Picagli J, Lee K, Jasne A. Stroke and COVID. 2024, 271-278. DOI: 10.1007/978-3-031-66289-8_24.Peer-Reviewed Original ResearchCore Measures and Data Collection
Nyström K, Jasne A. Core Measures and Data Collection. 2024, 155-165. DOI: 10.1007/978-3-031-66289-8_15.Peer-Reviewed Original ResearchAdjunctive Intravenous Argatroban or Eptifibatide for Ischemic Stroke
Adeoye O, Broderick J, Derdeyn C, Grotta J, Barsan W, Bentho O, Berry S, Concha M, Davis I, Demel S, Elm J, Gentile N, Graves T, Hoffman M, Huang J, Ingles J, Janis S, Jasne A, Khatri P, Levine S, Majjhoo A, Panagos P, Pancioli A, Pizzella S, Ranasinghe T, Sabagha N, Sivakumar S, Streib C, Vagal A, Wilson A, Wintermark M, Yoo A, Barreto A. Adjunctive Intravenous Argatroban or Eptifibatide for Ischemic Stroke. New England Journal Of Medicine 2024, 391: 810-820. PMID: 39231343, PMCID: PMC11528349, DOI: 10.1056/nejmoa2314779.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAnticoagulantsArginineCombined Modality TherapyDrug Therapy, CombinationEptifibatideFemaleFibrinolytic AgentsHumansIncidenceInfusions, IntravenousIntracranial HemorrhagesIschemic StrokeMaleMiddle AgedPeptidesPipecolic AcidsPlatelet Aggregation InhibitorsSingle-Blind MethodSulfonamidesThrombectomyThrombolytic TherapyTreatment OutcomeConceptsSymptomatic intracranial hemorrhageIntravenous argatrobanIntravenous thrombolysisAcute ischemic strokeIntracranial hemorrhageIschemic strokeIncidence of symptomatic intracranial hemorrhageSymptom onsetIschemic stroke treated with intravenous thrombolysisAcute ischemic stroke treated with intravenous thrombolysisStroke treated with intravenous thrombolysisAssociated with increased mortalityRankin Scale scoreInitiation of thrombolysisControlled clinical trialsTreatment of acute ischemic strokePlacebo groupEptifibatide groupEfficacy outcomesArgatroban groupStandard treatmentAdjunctive treatmentPlaceboClinical trialsArgatrobanTemporal Trends and Racial Disparities in Long-Term Survival After Stroke
Robinson D, Ding L, Howard G, Stanton R, Khoury J, Sucharew H, Haverbusch M, Nobel L, Khatri P, Adeoye O, Broderick J, Ferioli S, Mackey J, Woo D, Rios La Rosa F, Flaherty M, Slavin S, Star M, Martini S, Demel S, Walsh K, Coleman E, Jasne A, Mistry E, Kleindorfer D, Kissela B. Temporal Trends and Racial Disparities in Long-Term Survival After Stroke. Neurology 2024, 103: e209653. PMID: 39008784, PMCID: PMC11249510, DOI: 10.1212/wnl.0000000000209653.Peer-Reviewed Original ResearchConceptsPremorbid functional statusFunctional statusRacial disparitiesAcute ischemic strokeBlack individualsPopulation-based stroke studyBlack raceEffect of black raceNational Death IndexAssociated with 5-year mortalityBaseline functional statusAcute ischemic stroke casesRisk of deathPhysician adjudicationIntracerebral hemorrhageDeath IndexIntracerebral hemorrhage casesUS populationICD codesGeneral populationCalendar yearLogistic regressionModified Rankin ScaleStroke StudyMedical recordsProjections of Endovascular Therapy–Eligible Patients With Stroke for the US Population
Mistry E, Khoury J, Kleindorfer D, Kissela B, Alwell K, Jasne A, Ferioli S, La Rosa F, Coleman E, Demel S, Walsh K, Slavin S, Star M, Haverbusch M, Mackey J, Woo D, Aziz Y, Heldner M, Fischer U, Jadhav A, Jovin T, Albers G, Nogueira R, Khatri P. Projections of Endovascular Therapy–Eligible Patients With Stroke for the US Population. Stroke 2024, 55: 2011-2019. PMID: 38934124, DOI: 10.1161/strokeaha.123.045766.Peer-Reviewed Original ResearchUS populationStudy of stroke incidenceEndovascular thrombectomyNational Institutes of Health Stroke ScalePrevalence of large vessel occlusionHealth Stroke ScaleIschemic strokeEVT-eligible patientsUnited StatesPopulation-basedPrestroke disabilityStroke systemsStroke incidenceYears of ageLarge vessel occlusionEligibility criteriaAcute ischemic strokePost hoc analysisStroke ScaleObservational studyEligibilityAdult patientsTreatment indicationsHospitalized patientsNational InstituteClinical Trial Exclusion Criteria Affect Trial Inclusivity by Race and Sex
Stanton R, Aziz Y, Sucharew H, Haverbusch M, Robinson D, Coleman E, La Rosa F, Demel S, Ferioli S, Mackey J, Jasne A, Madsen T, Mistry E, Slavin S, Star M, Walsh K, Woo D, Khatri P, Broderick J, Kissela B, Kleindorfer D. Clinical Trial Exclusion Criteria Affect Trial Inclusivity by Race and Sex. Journal Of The American Heart Association 2024, 13: e035102. PMID: 38904225, PMCID: PMC11255719, DOI: 10.1161/jaha.124.035102.Peer-Reviewed Original ResearchImpact of Poverty on Stroke Recurrence: A Population-Based Study.
Becker C, Sucharew H, Robinson D, Stamm B, Royan R, Nobel L, Stanton R, Jasne A, Woo D, De Los Rios La Rosa F, Mackey J, Ferioli S, Mistry E, Demel S, Haverbusch M, Coleman E, Slavin S, Walsh K, Star M, Flaherty M, Martini S, Kissela B, Kleindorfer D. Impact of Poverty on Stroke Recurrence: A Population-Based Study. Neurology 2024, 102: e209423. PMID: 38759136, PMCID: PMC11175648, DOI: 10.1212/wnl.0000000000209423.Peer-Reviewed Original ResearchConceptsNeighborhood socioeconomic statusPopulation-based studyIncident strokeCensus tractsSecondary analysisGreater Cincinnati/Northern Kentucky regionStroke recurrencePoisson regression modelsPoverty lineFederal poverty lineRecurrent strokeRecurrence riskVascular risk factorsResidents of poor neighborhoodsStudy periodAmerican Community SurveyNeighborhood povertySocioeconomic statusExcess riskStroke incidenceImpact of povertyPrimary exposureRelative riskStroke recurrence riskWhite individualsRacial Disparities in Blood Pressure at Time of Acute Ischemic Stroke Presentation: A Population Study
Aziz Y, Sucharew H, Stanton R, Alwell K, Ferioli S, Khatri P, Adeoye O, Flaherty M, Mackey J, La Rosa F, Martini S, Mistry E, Coleman E, Jasne A, Slavin S, Walsh K, Star M, Ridha M, Ades L, Haverbusch M, Demel S, Woo D, Kissela B, Kleindorfer D. Racial Disparities in Blood Pressure at Time of Acute Ischemic Stroke Presentation: A Population Study. Journal Of The American Heart Association 2024, 13: e032645. PMID: 38700029, PMCID: PMC11179936, DOI: 10.1161/jaha.123.032645.Peer-Reviewed Original ResearchConceptsNational Institutes of Health Stroke Scale scoreWhite patientsStroke Scale scoreAcute ischemic strokeBlood pressureGreater Cincinnati/Northern Kentucky Stroke StudyDiastolic BPBlack patientsPopulation-based studyStudy epochInfluence clinical decision-makingScale scoreStroke risk factorsPresenting blood pressureIschemic strokeSubanalysis of patientsBody mass indexNational InstituteHistory of hypertensionMultivariate linear regressionClinical trial eligibilityAcute ischemic stroke presentingClinical decision-makingIschemic stroke presentingRacial disparitiesMigration of Iophendylate Myelography Contrast to the Brain With Successful Thrombectomy.
Tu L, Hegde R, Prust M, Mageid R, Hebert R, Jasne A. Migration of Iophendylate Myelography Contrast to the Brain With Successful Thrombectomy. Neurology 2024, 102: e209314. PMID: 38547442, DOI: 10.1212/wnl.0000000000209314.Peer-Reviewed Original ResearchHealth Factors Associated With Development and Severity of Poststroke Dysphagia: An Epidemiological Investigation
Krekeler B, Schieve H, Khoury J, Ding L, Haverbusch M, Alwell K, Adeoye O, Ferioloi S, Mackey J, Woo D, Flaherty M, La Rosa F, Demel S, Star M, Coleman E, Walsh K, Slavin S, Jasne A, Mistry E, Kleindorfer D, Kissela B. Health Factors Associated With Development and Severity of Poststroke Dysphagia: An Epidemiological Investigation. Journal Of The American Heart Association 2024, 13: e033922. PMID: 38533959, PMCID: PMC11179757, DOI: 10.1161/jaha.123.033922.Peer-Reviewed Original ResearchConceptsHistory of high cholesterolDysphagia statusLogistic regressionFactors associated with reduced riskHealth risk factorsPopulation-based studyFactors associated with increased riskNational Institutes of Health Stroke Scale scoreMultivariate logistic regressionRisk of dysphagiaPoststroke dysphagiaHemorrhagic stroke casesStroke Scale scoreStroke casesDevelopment of dysphagiaStroke recoveryPercutaneous endoscopic gastrostomy tube placementBlack raceRight hemisphere strokeHemorrhagic strokeHigh cholesterolRisk factorsAcute strokeFactors associated with developmentChart reviewTrends Over Time in Stroke Incidence by Race in the Greater Cincinnati Northern Kentucky Stroke Study
Madsen T, Ding L, Khoury J, Haverbusch M, Woo D, Ferioli S, De Los Rios La Rosa F, Martini S, Adeoye O, Khatri P, Flaherty M, Mackey J, Mistry E, Demel S, Coleman E, Jasne A, Slavin S, Walsh K, Star M, Broderick J, Kissela B, Kleindorfer D. Trends Over Time in Stroke Incidence by Race in the Greater Cincinnati Northern Kentucky Stroke Study. Neurology 2024, 102: e208077. PMID: 38546235, PMCID: PMC11097768, DOI: 10.1212/wnl.0000000000208077.Peer-Reviewed Original ResearchMediation of Age and Thrombectomy Outcome by Neuroimaging Markers of Frailty in Patients With Stroke
Benali F, Singh N, Fladt J, Jaroenngarmsamer T, Bala F, Ospel J, Buck B, Dowlatshahi D, Field T, Hanel R, Peeling L, Tymianski M, Hill M, Goyal M, Ganesh A, Barber P, Smith E, Bal S, Subramanian S, Peters S, Couillard P, Klein G, Stys P, Coutts S, Wong J, Mitha A, Eesa M, Morrish W, Alqatani S, Kashani N, Venkatesan P, Teleg E, Sitaram A, Graham B, Gaal S, Moussaddy A, Chakraborty D, Maraj N, Lockey A, Chen S, Singh R, Alsultan A, Asunsian R, Tse D, Doshi D, Volny O, Ojha P, Wadhwa A, Marko M, Singh N, Wasyliw S, Ryckborst K, Kenney C, Save S, Jambula A, Newcommon N, Hull G, Blackstock D, Kiszczak S, Zimmel L, Wright M, Jahraus C, Andersen L, Bohn S, Paul J, Buck B, Butcher K, Shuaib A, Jeerakathil T, Jickling G, Emery D, Rempel J, Ower R, Ashforth R, Yeo T, Kotylak T, O;Kelly C, Chow M, Siddiqui M, Saqqur M, D'Souza A, Lloret M, Butt A, Nomani A, Kalashyan H, Thirunavukkarasu S, Jabs J, Fairall P, Piquette L, Phillips S, Green A, Gubitz G, Heidenreich J, Huynh T, Shankar J, Maloney W, Vandorpe R, Schmidt M, Pickett G, Weeks A, Jarrett J, MacDonald D, Arsenault J, Kinnear R, Mandzia J, Mayich M, Boulton M, Bullrich M, Fridman S, Kiwan R, Lee D, Lownie S, Khaw A, Pandey S, Sharma M, Sposato L, Wade K, Beauchamp B, Lambourn L, Amato-Marziali B, Roy D, Deneault N, Deschaintre Y, Gioia L, Jacquin G, Odier C, Stapf C, Iancu D, Raymond J, Weill A, Lapierre M, Jadil N, Jolteus J, Teitelbaum J, Angle M, Hannouche M, Badawy M, Letourneau J, Cortes M, Linnell G, Tampieri D, Vieira L, Legault C, Durcan L, Moore A, Cole E, Magnussen C, Salmon K, Khalil S, Desloges I, Waxman L, Abdon W, Lai S, Dowlatshahi D, Shamy M, Stotts G, Blacquiere D, Lesiuk H, Quateen A, Drake B, Dewar B, Daham Z, Kelly M, Hunter G, Peeling L, Graham B, Whelan R, Garner A, Urroz L, Maley S, Silver F, Casaubon L, Pikula A, Campo M, Schaafsma J, Jaigobin C, Krings T, Pereira V, Agid R, Farb R, Kalman L, Cayley A, Williams J, Stewart T, Misquitta K, Bharatha A, Selchen D, Marotta T, Sarma D, Montanera W, Spears J, Saposnik G, Kostyrko P, Li Y, Parra-Farinas C, Diestro J, Camden M, Verreault S, Mackey A, Audet M, Milot G, Lavoie P, Gariépy J, Collard K, Haché A, Sahlas D, Alshanbari A, Baldwin J, Catanese L, Chen B, Sa Boasquevisque D, Deshmukh A, Knapman J, Lamers S, Larrazabal R, MacMillan S, Mai L, Mattai A, Nayar S, Ng K, Oczkowski W, Perera K, Shawawrah M, Shoamanesh A, Sobhi G, Syed N, Yaher N, Vandervelde C, Wang D, Field T, Van Gaal S, Teal P, Benavente O, Wilson L, Mann S, Yip S, Murphy C, Heran M, Rohr A, Settecase F, Redekop G, Haw C, Maclean G, Murray K, Chiu R, Flexman A, Strecha E, Gayton Y, Yip J, Swartz R, Boulos M, Gladstone D, Yu A, Hopyan J, Khosravani H, Manosalva Alzate H, Southwell A, Kamra M, Lopes K, Kapoor A, da Costa L, Yang V, Dyer E, Shah R, Knowles B, Nichols J, Patterson J, Cope K, Dickerson L, Barton K, Gray K, Massengale T, Miller M, Simpson C, Walker S, Tennyson-Yemm C, Frei D, Bellon R, Atchie B, Kaminsky I, Wilson D, Schraeder N, Arias E, Kodis L, Talley M, Edinger A, Talley T, Dempsey I, Williams L, Williams S, Kupniewski S, Fasbinder B, Snead J, Choe H, Mackenzie L, Weisman D, Kozak O, Shah Q, Gzesh D, Kulandaivel K, Khoury J, Klein B, Bussinger P, Griffin L, DePalmo A, Oliva C, Jadhav A, Jovin T, Kenmuir C, Jankowitz B, Gross B, Rocha M, Starr M, Brown M, Hawkes C, Shah K, Tememe D, Walker G, Patel P, Klein B, Ziayee H, Limaye K, Baxendell L, Glichrist V, Feineigle P, Toseki Haibach K, Van Every C, Desai S, Zulfiqar M, Gibson L, Barrett S, Turkel-Parrella D, Arcot K, DiCrescento S, Farkas J, Filipowski G, Frontera J, Joset D, Liff J, Scher E, McDougall C, Kelly C, Patel A, Monteith S, Starkman S, Atchaneeyasakul K, Burgos A, Anne Y. Chua J, Gaines N, Grunberg I, Guzy J, Liu Z, Maluste N, Ramirez L, Sharma L, Heck D, Brown M, McDonald C, Calderon M, Hargis M, Roels C, Emmady P, Alvi T, Jayaraman M, Cutting S, Smith W, Foley S, Paolucci G, Haas R, Quinn K, Fuller L, Brierley R, Watkins C, Demir N, Lopez G, Vargas A, Osteraas N, Holtz B, Sauvageau E, Aghaebrahim A, Chmayssani M, Naval N, Day J, Dellorso S, Ludwig B, Schemmel D, Ebreo N, Bell K, Lewis L, Delucia M, Haussen D, Frankel M, Bhatt N, Bianchi N, Anderson A, Belagaje S, Liberato B, Rangaraju S, Al-Bayati A, Grossber J, Craft L, Schindler K, Schaad E, Schultz M, Sutherly L, Doppelheuer S, Charlton J, Faggard J, Barbret Z, DukSoo Han E, Walters R, Dolia J, El-Jamal S, Eby B, Saleem Y, Pearl H, Patel K, Rahman H, Butt R, English S, Puri A, Howk M, Singh J, Massari F, DeMacedo Rodrigues K, Kuhn A, English J, Barazangi N, Telischak N, Kim W, Ross J, DeVole N, Redford J, Ferreira M, Ponting K, Shen H, Bedenk A, Patel S, Fernandess J, Ke M, Spokoyny I, Gao B, Tong D, Chen C, Wong C, Choe J, Martin C, Summers D, Boutwell C, Olds K, Crandall S, Eatman J, Akhtar N, Holloway W, Halpin J, Donegan B, Schindler J, Hwang D, Gilmore E, Petersen N, Sheth K, Brown S, Beekman R, George B, Kaddouh F, Falcone G, Wira C, Matouk C, Loomis C, Amin H, Stretz H, Narula R, Jasne A, Sansing L, Agarwal T, Jasak S, Fontaine B, King Z, Kouhn L, Orgass H, Leary M, Nye J, Halbert K, Nystrom K, Neuschatz K, Petrucci D, Coppola A, Joyce T, Hou S, Umekubo M, Nakamura C, Ovando R, Zuniga D, Nien Y, Basto F, Arch A, Jong L, Conrad W, Abbott T, Yao J, Caganap S, Jordan J, Teitelbaum G, Darflinger R, Kelly D, Gupta R, Budzik R, Czerniak J, Groezinger K, Hicks W, Kaskar O, Katz B, Loochtan A, Pema P, Rai V, Vora N, Brown A, Goodman D, Danenbergs B, Gossett M, Bang O, Chung J, Jeon P, Kim K, Lim Y, Hoe Heo J, Nam H, Kim Y, Park H, Hwang I, Ha W, Choi J, Jeong K, Rha J, Park H, Yoon C, Kim B, Sohn S, Kim C, Yoo J, Hong J, Park H, Kim S, Choi M, Bae H, Lee J, Lee J, Jun G, Jeon S, Campbell B, Mitchell P, Yassi N, Davis S, Donnan G, Parsons M, Yan B, Dowling R, Bush S, Wu T, Shan D, Zhao H, Salvaris P, Alemseged F, Ng F, Williams C, Balabanski A, dos Santos A, Ng J, McDonald A, Jackson D, Tsoleridis J, Pesavento L, Kleinig T, Drew R, Cranefield J, Scroop R, Cagi L, Harvey J, Waters M, Thornton J, Brennan R, O'Hare A, Power S, Williams D, Boyle K, Moynihan B, Liddy A, Large M, Cullen A, Walsh R, Martin E, Lynch J, McElroy S, Murphy S, Coveney S, Deegan C, Horgan G, Kelly P, Laffan A, Llamas-Osorio Y, Lynch C, Mac Mahon P, Marnane M, McCabe J, Burns P, Tauro S, Cuddy S, Rennie I, Smyth G, Flynn P, Wiggam I, Kerr E, Gordon P, Fearon P, Roberts G, Patterson C, Adams K, Wells B, McFarland M, Moreira T, Sjöstrand C, Mazya M, Almqvist H, Wahlgren N, Steinberg A, Cooray C, Eriksson E, Thorén M, Keselman B, Ahmed N, Holmberg Å, Axelsson M, Berglund A, Golsari A, Hoppe J, Deb-Chatterji M, Cheng B, Barow E, Schlemm E, Lettow I, Jensen M, Otto D, Jaramillo K, Appelbohm H, Fiehler J, Bester M, Schönfeld M, Brekenfeld C, Holst B, Wortmann G, Koch F, Gerber J, Abramyuk A, Kaiser D, Winzer S, Prakapenia A, Pallesen L, Siepmann T, Barlinn K, Haase K, Sauer A, Psychogios M, Liman J, Brehm A, Maus V, Hollstein N, Reinke A, Neitz G, Schnieder M, Schwarz M, Ibrahim A, Müller J, Meister S, Bäumle B, Chapot R, Pilgram-Pastor S, Wallocha M, Stauder M, Celik E, Stracke P, Müller N, Weber R, Veltkamp R, Nagel S, Ringleb P, Heyse M, Amiri H, Mundiyanapurath S, Chen M, Beyrle E, Beck P, Möhlenbruch M. Mediation of Age and Thrombectomy Outcome by Neuroimaging Markers of Frailty in Patients With Stroke. JAMA Network Open 2024, 7: e2349628. PMID: 38165676, PMCID: PMC10762575, DOI: 10.1001/jamanetworkopen.2023.49628.Peer-Reviewed Original ResearchConceptsMarker of frailtyEndovascular thrombectomyAlteplase treatmentCohort studyESCAPE-NA1 trialAcute ischemic strokeEarly ischemic changesSmall vessel diseaseBest medical managementAcute care hospitalsBrain frailtyFrailty featuresIschemic strokeStroke severityBrain atrophyCare hospitalIschemic changesPrimary outcomeClinical featuresMedical managementPuncture timeThrombectomy outcomesPoor outcomeVessel diseaseFunctional outcome
2023
Association of Neighborhood-Level Socioeconomic Factors With Delay to Hospital Arrival in Patients With Acute Stroke
Forman R, Okumu R, Mageid R, Baker A, Neu D, Parker R, Peyravi R, Schindler J, Sansing L, Sheth K, de Havenon A, Jasne A, Narula R, Wira C, Warren J, Sharma R. Association of Neighborhood-Level Socioeconomic Factors With Delay to Hospital Arrival in Patients With Acute Stroke. Neurology 2023, 102: e207764. PMID: 38165368, PMCID: PMC10834135, DOI: 10.1212/wnl.0000000000207764.Peer-Reviewed Original ResearchConceptsEmergency department arrival timesEmergency medical servicesLate presentationAcute ischemic stroke therapyYale-New Haven HospitalGuidelines-Stroke registryNeighborhood-level socioeconomic factorsPatient-level factorsRetrospective observational studyIschemic stroke therapyMixed-effects logistic regression modelNon-white patientsNon-white raceUnivariate logistic regressionNew Haven HospitalLogistic regression modelsHospital presentationTreatment ineligibilityStroke RegistryAcute strokeHospital arrivalStroke therapyUnivariate analysisObservational studyPatientsAcute and subacute neurovascular impact of cryptogenic air emboli
Gummerson C, Parasram M, Peng T, Picard J, Kahn P, Angelus E, Bhatt S, de Havenon A, Jasne A, Magid-Bernstein J. Acute and subacute neurovascular impact of cryptogenic air emboli. Surgical Neurology International 2023, 14: 285. PMID: 37680929, PMCID: PMC10481802, DOI: 10.25259/sni_382_2023.Peer-Reviewed Case Reports and Technical NotesMagnetic resonance imagingCortical diffusion restrictionAir emboliMiddle cerebral artery territoryRight anterior cerebral arterySubsequent magnetic resonance imagingDiffusion restrictionClose neurologic monitoringNeurocritical care managementCerebral air embolismAcute ischemic strokeAnterior cerebral arteryInitial radiographic findingsCerebral air emboliType of injuryComputerized tomography scanCourse of careArtery territoryCerebral edemaIschemic strokeNeurologic monitoringCerebral arteryCortical veinsInitial imagingMechanical ventilationIdentifying optimal cut points of National Institutes of Health Stroke Scale to Predict Mortality: A Population-based Assessment (P11-5.016)
Stanton R, Robinson D, Reeves M, Ding L, Khoury J, Haverbusch M, Alwell K, Adeoye O, Coleman E, De Los Rios La Rosa F, Demel S, Ferioli S, Flaherty M, Jasne A, Khatri P, Mackey J, Martini S, Mistry E, Slavin S, Star M, Woo D, Walsh K, Kissela B, Kleindorfer D. Identifying optimal cut points of National Institutes of Health Stroke Scale to Predict Mortality: A Population-based Assessment (P11-5.016). Neurology 2023, 100 DOI: 10.1212/wnl.0000000000203611.Peer-Reviewed Original ResearchTrends in Disparities in Advanced Neuroimaging Utilization in Acute Stroke: A Population-Based Study
Vagal A, Sucharew H, Wang L, Kissela B, Alwell K, Haverbusch M, Woo D, Ferioli S, Mackey J, La Rosa F, Mistry E, Demel S, Coleman E, Jasne A, Walsh K, Khatri P, Slavin S, Star M, Stephens C, Kleindorfer D. Trends in Disparities in Advanced Neuroimaging Utilization in Acute Stroke: A Population-Based Study. Stroke 2023, 54: 1001-1008. PMID: 36972349, DOI: 10.1161/strokeaha.122.040790.Peer-Reviewed Original ResearchConceptsPopulation-based studyAdvanced imagingSocioeconomic statusAcute strokeOlder patientsAdvanced neuroimagingStroke/transient ischemic attack eventsTransient ischemic attack eventsUS census tractsTransient ischemic attackLow SES patientsMultivariable logistic regressionHospital admission dateHigher socioeconomic statusIschemic attackYounger patientsSES patientsWhite patientsBlack patientsAdmission dateMultivariable modelAttack onsetSES-related disparitiesPatientsSecondary objectiveChanging Trends in Demographics, Risk Factors, and Clinical Features of Patients With Infective Endocarditis–Related Stroke, 2005–2015
Ridha M, Flaherty M, Aziz Y, Ades L, Alwell K, Khoury J, Woo D, Ferioli S, Adeoye O, Khatri P, De Los Rios La Rosa F, Mistry E, Demel S, Mackey J, Martini S, Coleman E, Jasne A, Slavin S, Walsh K, Star M, Haverbusch M, Madsen T, Broderick J, Kissela B, Kleindorfer D. Changing Trends in Demographics, Risk Factors, and Clinical Features of Patients With Infective Endocarditis–Related Stroke, 2005–2015. Neurology 2023, 100: e1555-e1564. PMID: 36746635, PMCID: PMC10103121, DOI: 10.1212/wnl.0000000000206865.Peer-Reviewed Original ResearchConceptsRisk factorsOpioid epidemicClinical characteristicsClinical featuresGreater Cincinnati/Northern Kentucky regionStudy periodRetrospective cohort studyRates of hypertensionIntravenous drug useIntravenous drug usersICD-10 codesCochran-Armitage testPerioperative strokeAcute strokeCohort studyDefinite endocarditisDuke criteriaHypertension prevalenceIschemic strokeYounger patientsStroke populationInfective endocarditisAtrial fibrillationEpidemiologic descriptionUnadjusted comparisons