2024
Burden of Neurologic Health Care and Incident Neurologic Diagnoses in the Year After COVID-19 or Influenza Hospitalization.
de Havenon A, Callaghan B, Xu Y, Connor M, Hill C, Ney J, Esper G. Burden of Neurologic Health Care and Incident Neurologic Diagnoses in the Year After COVID-19 or Influenza Hospitalization. Neurology 2024, 102: e209248. PMID: 38507675, PMCID: PMC11383855, DOI: 10.1212/wnl.0000000000209248.Peer-Reviewed Original ResearchConceptsHealth care encountersNeurological diagnosisCare encountersHealth careCollection of electronic health recordsHospital-based careHealth Research NetworkElectronic health recordsEmergency department visitsCohort of adultsYears of follow-upGlobal health research networkPatient-level dataElixhauser comorbidity scorePropensity score matchingHealth recordsMovement disordersDepartment visitsEMR dataPatient's residenceMarital statusAnalysis of patient-level dataNearest neighbor propensity score matchingIncident eventsHazard ratio
2022
Life stressors significantly impact long-term outcomes and post-acute symptoms 12-months after COVID-19 hospitalization
Frontera J, Sabadia S, Yang D, de Havenon A, Yaghi S, Lewis A, Lord A, Melmed K, Thawani S, Balcer L, Wisniewski T, Galetta S, Agarwal S, Andino A, Arena V, Baskharoun S, Bauman K, Bell L, Berger S, Bhagat D, Bokhari M, Bondi S, Canizares M, Chervinsky A, Czeisler B, Dygert L, Fang T, Flusty B, Friedman D, Friedman D, Fuchs B, Granger A, Gratch D, Gurin L, Gutman J, Hasanaj L, Holmes M, Horng J, Huang J, Ishii H, Jauregui R, Ji Y, Kahn D, Koch E, Krieger P, Kvernland A, Lalchan R, Lillemoe K, Lin J, Liu S, Madhavan M, Medicherla C, Millar-Vernetti P, Morgan N, Olivera A, Omari M, Park G, Patel P, Ristic M, Rosenthal J, Sonson M, Snyder T, Stainman R, Sunwoo B, Talmasov D, Tamimi M, Thomas B, Valdes E, Zhou T, Zhu Y. Life stressors significantly impact long-term outcomes and post-acute symptoms 12-months after COVID-19 hospitalization. Journal Of The Neurological Sciences 2022, 443: 120487. PMID: 36379135, PMCID: PMC9637014, DOI: 10.1016/j.jns.2022.120487.Peer-Reviewed Original ResearchMeSH KeywordsActivities of Daily LivingCOVID-19FatigueFemaleHospitalizationHumansLongitudinal StudiesProspective StudiesQuality of LifeConceptsModified Rankin ScalePost-acute symptomsLong-term outcomesCOVID-19 hospitalizationBaseline disabilityBarthel IndexPoor outcomeFemale sexLife stressorsCOVID-19Telephone Montreal Cognitive AssessmentOlder ageMultivariable logistic regressionStrong independent predictorCOVID-19 patientsLongitudinal cohort studyCOVID-19 severityWorse mRSMontreal Cognitive AssessmentProlonged symptomsRankin ScaleCohort studyIndependent predictorsMultivariable analysisNeuropsychiatric outcomes
2021
Characteristics and Outcomes Among US Patients Hospitalized for Ischemic Stroke Before vs During the COVID-19 Pandemic
de Havenon A, Ney JP, Callaghan B, Hohmann S, Shippey E, Yaghi S, Anadani M, Majersik JJ. Characteristics and Outcomes Among US Patients Hospitalized for Ischemic Stroke Before vs During the COVID-19 Pandemic. JAMA Network Open 2021, 4: e2110314. PMID: 33999162, PMCID: PMC8129817, DOI: 10.1001/jamanetworkopen.2021.10314.Peer-Reviewed Original ResearchConceptsIschemic strokeCOVID-19 groupCohort studyUS patientsCOVID-19Prepandemic levelsLaboratory-confirmed COVID-19Vizient Clinical Data BaseCOVID-19 pandemicRetrospective cohort studyAcute coronary syndromeOutcomes of hospitalizationHospital discharge ratesTime of admissionHospitalization of patientsCOVID-19 statusClinical data baseNonelective basisCoronary syndromeHospital deathHospital dischargePulmonary emboliBaseline factorsHispanic patientsNonfederal hospitalsImpact of COVID-19 on the hospitalization, treatment, and outcomes of intracerebral and subarachnoid hemorrhage in the United States
Ravindra VM, Grandhi R, Delic A, Hohmann S, Shippey E, Tirschwell D, Frontera JA, Yaghi S, Majersik JJ, Anadani M, de Havenon A. Impact of COVID-19 on the hospitalization, treatment, and outcomes of intracerebral and subarachnoid hemorrhage in the United States. PLOS ONE 2021, 16: e0248728. PMID: 33852591, PMCID: PMC8046225, DOI: 10.1371/journal.pone.0248728.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overCerebral HemorrhageChildChild, PreschoolCohort StudiesCOVID-19EthnicityFemaleHospital MortalityHospitalizationHumansInfantLength of StayMaleMiddle AgedMinority GroupsPatient DischargeRetrospective StudiesSARS-CoV-2Subarachnoid HemorrhageTreatment OutcomeUnited StatesConceptsAdjusted odds ratioHospital death rateIntensive care stayOutcome of deathIntracerebral hemorrhageSubarachnoid hemorrhageFavorable dischargeCOVID-19Vizient Clinical Data BaseDeath rateLonger hospital lengthIntensive care lengthLength of hospitalLonger hospital stayCohort of patientsMixed-effects logistic regression modelSpontaneous intracerebral hemorrhageCOVID-19 infectionClinical data baseLogistic regression modelsICH controlsHospital deathHospital stayHospital lengthSecondary outcomesToxic Metabolic Encephalopathy in Hospitalized Patients with COVID-19
Frontera JA, Melmed K, Fang T, Granger A, Lin J, Yaghi S, Zhou T, Lewis A, Kurz S, Kahn DE, de Havenon A, Huang J, Czeisler BM, Lord A, Meropol SB, Troxel AB, Wisniewski T, Balcer L, Galetta S. Toxic Metabolic Encephalopathy in Hospitalized Patients with COVID-19. Neurocritical Care 2021, 35: 693-706. PMID: 33725290, PMCID: PMC7962078, DOI: 10.1007/s12028-021-01220-5.Peer-Reviewed Original ResearchMeSH KeywordsBrain DiseasesBrain Diseases, MetabolicCOVID-19Hospital MortalityHospitalizationHumansRetrospective StudiesSARS-CoV-2ConceptsHypoxic-ischemic encephalopathyHospital mortalityTime-dependent Cox proportional hazards modelsSequential Organ Failure Assessment scoreSevere acute respiratory syndrome coronavirus 2Organ Failure Assessment scoreAcute respiratory syndrome coronavirus 2Intensive care unit requirementSARS-CoV-2 infectionCOVID-19Cox proportional hazards modelRespiratory syndrome coronavirus 2Longer hospital lengthNew York City hospitalsPrimary neurological diagnosisStructural brain diseaseToxic-metabolic encephalopathyDate of admissionSyndrome coronavirus 2Proportional hazards modelCoronavirus disease 2019Coprimary outcomesHospital deathHospital lengthObservational cohort
2020
A Prospective Study of Neurologic Disorders in Hospitalized COVID-19 Patients in New York City
Frontera JA, Sabadia S, Lalchan R, Fang T, Flusty B, Millar-Vernetti P, Snyder T, Berger S, Yang D, Granger A, Morgan N, Patel P, Gutman J, Melmed K, Agarwal S, Bokhari M, Andino A, Valdes E, Omari M, Kvernland A, Lillemoe K, Chou SH, McNett M, Helbok R, Mainali S, Fink EL, Robertson C, Schober M, Suarez JI, Ziai W, Menon D, Friedman D, Friedman D, Holmes M, Huang J, Thawani S, Howard J, Abou-Fayssal N, Krieger P, Lewis A, Lord AS, Zhou T, Kahn DE, Czeisler BM, Torres J, Yaghi S, Ishida K, Scher E, de Havenon A, Placantonakis D, Liu M, Wisniewski T, Troxel AB, Balcer L, Galetta S. A Prospective Study of Neurologic Disorders in Hospitalized COVID-19 Patients in New York City. Neurology 2020, 96: 10.1212/wnl.0000000000010979. PMID: 33020166, PMCID: PMC7905791, DOI: 10.1212/wnl.0000000000010979.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsAgedBrain DiseasesCOVID-19FemaleHospital MortalityHospitalizationHumansIntubation, IntratrachealMaleMiddle AgedNervous System DiseasesNeurotoxicity SyndromesNew York CityOrgan Dysfunction ScoresPatient DischargeProspective StudiesSex FactorsSpinal Cord DiseasesYoung AdultConceptsNew neurologic disordersSARS-CoV-2 infectionLikelihood of dischargeNeurologic disordersHospital mortalityHigher Sequential Organ Failure Assessment scoreLaboratory-confirmed SARS-CoV-2 infectionSequential Organ Failure Assessment scoreCOVID-19Severe acute respiratory syndrome coronavirus 2Organ Failure Assessment scoreAcute respiratory syndrome coronavirus 2Hospitalized COVID-19 patientsHypoxic/ischemic injuryCOVID-19 symptom onsetRespiratory syndrome coronavirus 2Meningitis/encephalitisSevere systemic illnessCOVID-19 patientsSyndrome coronavirus 2Coronavirus disease 2019SARS-CoV-2SOFA scoreHospital outcomesHospitalized adultsBlood pressure reduction and outcome after endovascular therapy: a secondary analysis of the BEST study
Anadani M, de Havenon A, Yaghi S, Mehta T, Arora N, Starosciak AK, La Rosa F, Siegler J, Mistry AM, Chitale R, Spiotta AM, Tsivgoulis G, Khatri P, Mistry EA. Blood pressure reduction and outcome after endovascular therapy: a secondary analysis of the BEST study. Journal Of NeuroInterventional Surgery 2020, 13: 698-702. PMID: 32883780, PMCID: PMC8088286, DOI: 10.1136/neurintsurg-2020-016494.Peer-Reviewed Original ResearchConceptsSystolic blood pressure reductionSystolic blood pressureBlood pressure reductionEndovascular therapyPoor functional outcomeSuccessful recanalizationBlood pressurePoor outcomeFunctional outcomeOutcome groupAdmission systolic blood pressureOutcomes of EVTProspective observational cohort studyBaseline systolic blood pressureElevated systolic blood pressurePressure reductionHistory of hypertensionObservational cohort studyPoor outcome groupProspective multicenter cohortGood outcome groupAntihypertensive treatmentRevascularization statusCohort studyMulticenter cohortAnticoagulation use and Hemorrhagic Stroke in SARS-CoV-2 Patients Treated at a New York Healthcare System
Kvernland A, Kumar A, Yaghi S, Raz E, Frontera J, Lewis A, Czeisler B, Kahn DE, Zhou T, Ishida K, Torres J, Riina HA, Shapiro M, Nossek E, Nelson PK, Tanweer O, Gordon D, Jain R, Dehkharghani S, Henninger N, de Havenon A, Grory BM, Lord A, Melmed K. Anticoagulation use and Hemorrhagic Stroke in SARS-CoV-2 Patients Treated at a New York Healthcare System. Neurocritical Care 2020, 34: 748-759. PMID: 32839867, PMCID: PMC7444897, DOI: 10.1007/s12028-020-01077-0.Peer-Reviewed Original ResearchConceptsHemorrhagic strokeTherapeutic anticoagulationClinical characteristicsThrombotic complicationsHistorical controlsCOVID-19Exact testHigher initial NIHSS scoreSARS-CoV-2 patientsInitial NIHSS scoreRetrospective cohort studyHealthcare systemFischer's exact testCOVID-19 infectionNon-aneurysmal SAHMajor healthcare systemOverall low rateAnticoagulation useEmpiric anticoagulationHospital mortalityNIHSS scoreCohort studyCommon etiologyIntraparenchymal hemorrhageMost hemorrhages