2022
Post-acute sequelae of COVID-19 symptom phenotypes and therapeutic strategies: A prospective, observational study
Frontera JA, Thorpe LE, Simon NM, de Havenon A, Yaghi S, Sabadia SB, Yang D, Lewis A, Melmed K, Balcer LJ, Wisniewski T, Galetta SL. Post-acute sequelae of COVID-19 symptom phenotypes and therapeutic strategies: A prospective, observational study. PLOS ONE 2022, 17: e0275274. PMID: 36174032, PMCID: PMC9521913, DOI: 10.1371/journal.pone.0275274.Peer-Reviewed Original ResearchConceptsPost-acute sequelaeDifferent therapeutic interventionsTherapeutic interventionsTherapeutic strategiesAcute SARS-CoV-2 infectionOccupational therapySARS-CoV-2 infectionOutcome metricsSimilar therapeutic interventionsProspective cohort studyShortness of breathAnti-anxiety medicationsLogistic regression analysisCOVID-19Individual treatment programsPASC symptomsCohort studySymptom improvementUnsupervised hierarchical cluster analysisTreatment strategiesObservational studySleep disordersVariable symptomatologySymptom groupsCognitive symptoms
2021
Impact of COVID-19 on the hospitalization, treatment, and outcomes of intracerebral and subarachnoid hemorrhage in the United States
Ravindra VM, Grandhi R, Delic A, Hohmann S, Shippey E, Tirschwell D, Frontera JA, Yaghi S, Majersik JJ, Anadani M, de Havenon A. Impact of COVID-19 on the hospitalization, treatment, and outcomes of intracerebral and subarachnoid hemorrhage in the United States. PLOS ONE 2021, 16: e0248728. PMID: 33852591, PMCID: PMC8046225, DOI: 10.1371/journal.pone.0248728.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overCerebral HemorrhageChildChild, PreschoolCohort StudiesCOVID-19EthnicityFemaleHospital MortalityHospitalizationHumansInfantLength of StayMaleMiddle AgedMinority GroupsPatient DischargeRetrospective StudiesSARS-CoV-2Subarachnoid HemorrhageTreatment OutcomeUnited StatesConceptsAdjusted odds ratioHospital death rateIntensive care stayOutcome of deathIntracerebral hemorrhageSubarachnoid hemorrhageFavorable dischargeCOVID-19Vizient Clinical Data BaseDeath rateLonger hospital lengthIntensive care lengthLength of hospitalLonger hospital stayCohort of patientsMixed-effects logistic regression modelSpontaneous intracerebral hemorrhageCOVID-19 infectionClinical data baseLogistic regression modelsICH controlsHospital deathHospital stayHospital lengthSecondary outcomesToxic Metabolic Encephalopathy in Hospitalized Patients with COVID-19
Frontera JA, Melmed K, Fang T, Granger A, Lin J, Yaghi S, Zhou T, Lewis A, Kurz S, Kahn DE, de Havenon A, Huang J, Czeisler BM, Lord A, Meropol SB, Troxel AB, Wisniewski T, Balcer L, Galetta S. Toxic Metabolic Encephalopathy in Hospitalized Patients with COVID-19. Neurocritical Care 2021, 35: 693-706. PMID: 33725290, PMCID: PMC7962078, DOI: 10.1007/s12028-021-01220-5.Peer-Reviewed Original ResearchConceptsHypoxic-ischemic encephalopathyHospital mortalityTime-dependent Cox proportional hazards modelsSequential Organ Failure Assessment scoreSevere acute respiratory syndrome coronavirus 2Organ Failure Assessment scoreAcute respiratory syndrome coronavirus 2Intensive care unit requirementSARS-CoV-2 infectionCOVID-19Cox proportional hazards modelRespiratory syndrome coronavirus 2Longer hospital lengthNew York City hospitalsPrimary neurological diagnosisStructural brain diseaseToxic-metabolic encephalopathyDate of admissionSyndrome coronavirus 2Proportional hazards modelCoronavirus disease 2019Coprimary outcomesHospital deathHospital lengthObservational cohort
2020
Cerebral Venous Sinus Thrombosis in the COVID-19 Pandemic.
Medicherla CB, Pauley RA, de Havenon A, Yaghi S, Ishida K, Torres JL. Cerebral Venous Sinus Thrombosis in the COVID-19 Pandemic. Journal Of Neuro-Ophthalmology 2020, 40: 457-462. PMID: 33186264, DOI: 10.1097/wno.0000000000001122.Peer-Reviewed Original ResearchMeSH KeywordsCerebral AngiographyCOVID-19HumansSARS-CoV-2Sinus Thrombosis, IntracranialUnited StatesConceptsCerebral venous sinus thrombosisVenous sinus thrombosisSinus thrombosisThromboembolic eventsRisk of CVSTNeuro-ophthalmologic complicationsSignificant visual deficitsCoronavirus disease 2019COVID-19COVID-19 pandemicNeurologic complicationsClinical presentationMultiple etiologiesDisease presentationVisual deficitsDisease 2019Disease pathophysiologyNovel COVID-19 pandemicComplicationsThrombosisVariable phenotypeRecent studiesPresentationThromboembolismPandemicExcess neurological death in New York City after the emergence of COVID-19
de Havenon A, Ney JP, Callaghan B, Yaghi S, Majersik JJ. Excess neurological death in New York City after the emergence of COVID-19. Journal Of Neurology 2020, 268: 2026-2028. PMID: 32691234, PMCID: PMC7370626, DOI: 10.1007/s00415-020-10084-2.Peer-Reviewed Original ResearchAcute stroke care in a New York City comprehensive stroke center during the COVID-19 pandemic
Agarwal S, Scher E, Rossan-Raghunath N, Marolia D, Butnar M, Torres J, Zhang C, Kim S, Sanger M, Humbert K, Tanweer O, Shapiro M, Raz E, Nossek E, Nelson PK, Riina HA, de Havenon A, Wachs M, Farkas J, Tiwari A, Arcot K, Parella DT, Liff J, Wu T, Wittman I, Caldwell R, Frontera J, Lord A, Ishida K, Yaghi S. Acute stroke care in a New York City comprehensive stroke center during the COVID-19 pandemic. Journal Of Stroke And Cerebrovascular Diseases 2020, 29: 105068. PMID: 32807471, PMCID: PMC7305900, DOI: 10.1016/j.jstrokecerebrovasdis.2020.105068.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overBetacoronavirusComprehensive Health CareCoronavirus InfectionsCOVID-19Critical PathwaysDelivery of Health Care, IntegratedFemaleHumansMaleMiddle AgedNew York CityPandemicsPatient Care TeamPneumonia, ViralQuality ImprovementQuality Indicators, Health CareRegistriesRetrospective StudiesSARS-CoV-2StrokeThrombectomyThrombolytic TherapyTime FactorsTime-to-TreatmentTreatment OutcomeWorkflowConceptsComprehensive stroke centerAcute ischemic strokePre-pandemic groupAIS patientsStroke centersTransient ischemic attack/strokeAcute stroke processDefect-free careLonger median doorEmergency health care servicesAcute stroke careConsecutive AIS patientsQuality improvement registrySuccessful recanalization rateLong-term outcomesQuality of careHealth care servicesCOVID-19 screeningAcute strokeIschemic strokeLonger doorMechanical thrombectomyMedian doorStroke severityDischarge outcomes