2020
Rabbit models of intracranial atherosclerotic disease for pathological validation of vessel wall MRI
McNally J, de Havenon A, Kim S, Wang C, Wang S, Zabriskie M, Parker D, Baradaran H, Alexander M. Rabbit models of intracranial atherosclerotic disease for pathological validation of vessel wall MRI. The Neuroradiology Journal 2020, 34: 193-199. PMID: 33325806, PMCID: PMC8165905, DOI: 10.1177/1971400920980153.Peer-Reviewed Original ResearchAnimalsDisease Models, AnimalIntracranial ArteriosclerosisMagnetic Resonance AngiographyRabbitsSensitivity and Specificity
2019
Effect of Time Elapsed since Gadolinium Administration on Atherosclerotic Plaque Enhancement in Clinical Vessel Wall MR Imaging Studies
de Havenon A, Muhina HJ, Parker DL, McNally JS, Alexander MD. Effect of Time Elapsed since Gadolinium Administration on Atherosclerotic Plaque Enhancement in Clinical Vessel Wall MR Imaging Studies. American Journal Of Neuroradiology 2019, 40: 1709-1711. PMID: 31515211, PMCID: PMC6785399, DOI: 10.3174/ajnr.a6191.Peer-Reviewed Original ResearchMeSH KeywordsContrast MediaFemaleGadoliniumHumansImage Interpretation, Computer-AssistedIntracranial ArteriosclerosisMagnetic Resonance AngiographyMalePlaque, AtheroscleroticRetrospective StudiesTime FactorsConceptsIntracranial atherosclerotic diseaseAtherosclerotic diseaseContrast administrationMR imaging studiesVessel wall MR imagingSignal intensity changesPlaque enhancementGadolinium administrationVessel wall MRImaging studiesMR imagingLonger durationAdministrationGreater increaseDiseaseDurationCohortTime ElapsedAssessment of quantitative methods for enhancement measurement on vessel wall magnetic resonance imaging evaluation of intracranial atherosclerosis
Alexander MD, de Havenon A, Kim SE, Parker DL, McNally JS. Assessment of quantitative methods for enhancement measurement on vessel wall magnetic resonance imaging evaluation of intracranial atherosclerosis. Neuroradiology 2019, 61: 643-650. PMID: 30675639, PMCID: PMC8022353, DOI: 10.1007/s00234-019-02167-3.Peer-Reviewed Original ResearchMeSH KeywordsAgedContrast MediaFemaleHumansImage EnhancementIntracranial ArteriosclerosisMagnetic Resonance AngiographyMaleMiddle AgedRetrospective StudiesStrokeConceptsIntracranial atherosclerotic diseaseVessel wall magnetic resonance imagingInter-rater agreementLower infundibulumHigh inter-rater agreementVessel wall magnetic resonanceGood inter-rater agreementPost-contrast imagingPresence of enhancementMagnetic resonance imagingPost-contrast imagesRatio of enhancementCulprit lesionIntracranial atherosclerosisAtherosclerotic diseaseInclusion criteriaBlinded reviewersResonance imagingLesion enhancementHigh agreementPlaque signalLesionsInfundibulumObjective dataMagnetic resonance
2018
Magnetic Resonance Imaging and Clinical Factors Associated With Ischemic Stroke in Patients Suspected of Cervical Artery Dissection
McNally JS, Hinckley PJ, Sakata A, Eisenmenger LB, Kim SE, De Havenon AH, Quigley EP, Iacob E, Treiman GS, Parker DL. Magnetic Resonance Imaging and Clinical Factors Associated With Ischemic Stroke in Patients Suspected of Cervical Artery Dissection. Stroke 2018, 49: 2337-2344. PMID: 30355108, PMCID: PMC6208137, DOI: 10.1161/strokeaha.118.021868.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedArteriesBrain IschemiaDiffusion Magnetic Resonance ImagingFemaleHematomaHumansMagnetic Resonance AngiographyMaleMiddle AgedReproducibility of ResultsRetrospective StudiesStrokeConceptsAcute ischemic strokeCervical artery dissectionIntramural hematomaIschemic strokeArtery dissectionT1-weighted sequencesIMH detectionMagnetic resonance imaging/magnetic resonance angiographyGradient-recalled echoMethods Institutional review board approvalIschemic stroke pathogenesisCardiovascular risk factorsStroke sourcesInterrater reliabilityMultivariate Poisson regressionReview board approvalMagnetic resonance angiographyMagnetic resonance imagingStroke prediction modelsStroke pathogenesisAcute strokeCurrent smokingClinical factorsAtherosclerotic diseaseImaging findings
2017
Added Value of Vessel Wall Magnetic Resonance Imaging for Differentiation of Nonocclusive Intracranial Vasculopathies
Mossa-Basha M, Shibata DK, Hallam DK, de Havenon A, Hippe DS, Becker KJ, Tirschwell DL, Hatsukami T, Balu N, Yuan C. Added Value of Vessel Wall Magnetic Resonance Imaging for Differentiation of Nonocclusive Intracranial Vasculopathies. Stroke 2017, 48: 3026-3033. PMID: 29030476, PMCID: PMC5687293, DOI: 10.1161/strokeaha.117.018227.Peer-Reviewed Original ResearchMeSH KeywordsAdultFemaleHumansIntracranial ArteriosclerosisMagnetic Resonance AngiographyMaleMiddle AgedRetrospective StudiesVasculitis, Central Nervous SystemVasospasm, IntracranialConceptsIntracranial vessel wall magnetic resonance imagingVessel wall magnetic resonance imagingLuminal imagingIntracranial vasculopathyMagnetic resonance imagingInflammatory vasculopathyWall involvementResonance imagingReversible cerebral vasoconstriction syndromeCerebral vasoconstriction syndromeIntracranial atherosclerotic diseasePattern of involvementAtherosclerotic diseaseLesion eccentricityPostcontrast enhancementClinical dataSyndrome patientsVasculopathyPatient basisPatient analysisDiagnostic agreementSlight agreementDiagnosisDiagnostic confidenceLesionsHigh-resolution vessel wall MRI for the evaluation of intracranial atherosclerotic disease
de Havenon A, Mossa-Basha M, Shah L, Kim SE, Park M, Parker D, McNally JS. High-resolution vessel wall MRI for the evaluation of intracranial atherosclerotic disease. Neuroradiology 2017, 59: 1193-1202. PMID: 28942481, DOI: 10.1007/s00234-017-1925-9.Peer-Reviewed Original ResearchMeSH KeywordsBrain IschemiaContrast MediaHumansIntracranial ArteriosclerosisMagnetic Resonance AngiographyStrokeConceptsHigh-resolution vessel wall MRIVessel wall MRIIntracranial atherosclerosisPrognosis of patientsIntracranial atherosclerotic diseasePost-contrast enhancementDiagnostic imaging techniquesHigh field strength MRIIschemic strokeStroke etiologyAtherosclerotic diseaseCerebrovascular diseaseVessel wall morphologyVascular pathologyIntracranial arteriesEnhancement patternRecurrence riskAtherosclerosisTranslational perspectiveVessel wallClinical interpretationMRIStrength MRIDiseaseAssociation of Collateral Blood Vessels Detected by Arterial Spin Labeling Magnetic Resonance Imaging With Neurological Outcome After Ischemic Stroke
de Havenon A, Haynor DR, Tirschwell DL, Majersik JJ, Smith G, Cohen W, Andre JB. Association of Collateral Blood Vessels Detected by Arterial Spin Labeling Magnetic Resonance Imaging With Neurological Outcome After Ischemic Stroke. JAMA Neurology 2017, 74: 453-458. PMID: 28192548, PMCID: PMC5470363, DOI: 10.1001/jamaneurol.2016.4491.Peer-Reviewed Original ResearchConceptsAcute ischemic strokeArterial spin labeling magnetic resonance imagingCollateral blood vesselsNeurologic outcomeMRS scoreMagnetic resonance imagingNeurological outcomeIschemic strokeScale scoreHealth Stroke Scale scoreResonance imagingMultivariable ordinal logistic regression modelsTertiary academic medical centerBlood vesselsAdmission National InstitutesPremorbid mRS scoreGood neurologic outcomeGood neurological outcomeRetrospective cohort studyStroke Scale scoreRankin Scale scorePresence of collateralsAcademic medical centerLogistic regression modelsOrdinal logistic regression models
2016
Vessel wall MRI of an inflamed aneurysm with atherosclerosis in a patient with ischemic stroke
de Havenon A, Park M, McNally S. Vessel wall MRI of an inflamed aneurysm with atherosclerosis in a patient with ischemic stroke. Neurology 2016, 87: 741-742. PMID: 27527539, PMCID: PMC4999170, DOI: 10.1212/wnl.0000000000002990.Peer-Reviewed Original ResearchPrediction of Carotid Intraplaque Hemorrhage Using Adventitial Calcification and Plaque Thickness on CTA
Eisenmenger LB, Aldred BW, Kim S, Stoddard GJ, de Havenon A, Treiman GS, Parker DL, McNally JS. Prediction of Carotid Intraplaque Hemorrhage Using Adventitial Calcification and Plaque Thickness on CTA. American Journal Of Neuroradiology 2016, 37: 1496-1503. PMID: 27102316, PMCID: PMC7960279, DOI: 10.3174/ajnr.a4765.Peer-Reviewed Original ResearchConceptsMaximum soft plaque thicknessCarotid intraplaque hemorrhageAdventitial calcificationIntraplaque hemorrhageRim signPlaque thicknessRetrospective cohort studyAtherosclerosis risk factorsMaximum plaque thicknessMultivariable Poisson regressionNASCET stenosisCohort studyAdventitial inflammationRisk factorsPlaque instabilityCarotid arteryHemorrhageUlcerationSoft plaqueStenosisIntraluminal thrombusPoisson regressionFinal modelCalcificationCarotid MRA
2015
Multicontrast High-Resolution Vessel Wall Magnetic Resonance Imaging and Its Value in Differentiating Intracranial Vasculopathic Processes
Mossa-Basha M, Hwang WD, De Havenon A, Hippe D, Balu N, Becker KJ, Tirschwell DT, Hatsukami T, Anzai Y, Yuan C. Multicontrast High-Resolution Vessel Wall Magnetic Resonance Imaging and Its Value in Differentiating Intracranial Vasculopathic Processes. Stroke 2015, 46: 1567-1573. PMID: 25953365, DOI: 10.1161/strokeaha.115.009037.Peer-Reviewed Original ResearchMeSH KeywordsAgedCerebral AngiographyCerebrovascular DisordersDiagnosis, DifferentialHumansMagnetic Resonance AngiographyMaleMiddle AgedConceptsReversible cerebral vasoconstriction syndromeVessel wall magnetic resonance imagingCerebral vasoconstriction syndromeMagnetic resonance imagingT2 hyperintensityIntracranial vasculopathyResonance imagingWall thickeningPattern of enhancementCases of atherosclerosisIntracranial vascular diseaseT2 signal characteristicsExcellent inter-reader agreementInter-reader agreementVasculitic lesionsInvasive workupWall involvementStenotic lesionsVasculopathic processPostcontrast enhancementVascular diseaseDifferential diagnosisVasculopathyLesion typeSyndrome