2024
Secondary Prevention in Patients With Stroke Versus Myocardial Infarction: Analysis of 2 National Cohorts
Rivier C, Acosta J, Leasure A, Forman R, Sharma R, de Havenon A, Spatz E, Inzucchi S, Kernan W, Falcone G, Sheth K. Secondary Prevention in Patients With Stroke Versus Myocardial Infarction: Analysis of 2 National Cohorts. Journal Of The American Heart Association 2024, 13: e033322. PMID: 38639369, PMCID: PMC11179946, DOI: 10.1161/jaha.123.033322.Peer-Reviewed Original ResearchMeSH KeywordsAgedAntihypertensive AgentsBlood PressureCross-Sectional StudiesFemaleHumansHydroxymethylglutaryl-CoA Reductase InhibitorsMaleMiddle AgedMyocardial InfarctionPlatelet Aggregation InhibitorsPractice Guidelines as TopicRisk AssessmentRisk FactorsSecondary PreventionStrokeUnited KingdomUnited StatesConceptsMyocardial infarctionPrevention scoreSecondary preventionImplementation of preventive therapyNational cohortUK BiobankAntiplatelet therapy useGuideline-directed therapyPrevention profilesBlood pressure controlAdherence to guideline-directed therapyLow-density lipoprotein controlNeighborhood deprivation levelHistory of strokeVascular risk profileStatin useAntiplatelet useTherapy usePreventive therapyComparison to participantsPrevention criteriaCross-sectional analysisBlood pressurePatientsPressure controlImpact of sleep quality and physical activity on blood pressure variability
de Havenon A, Falcone G, Rivier C, Littig L, Petersen N, de Villele P, Prabhakaran S, Kimberly W, Mistry E, Sheth K. Impact of sleep quality and physical activity on blood pressure variability. PLOS ONE 2024, 19: e0301631. PMID: 38625967, PMCID: PMC11020843, DOI: 10.1371/journal.pone.0301631.Peer-Reviewed Original ResearchConceptsSleep qualityPhysical activityOdds ratioCohort of community-dwelling adultsCommunity-dwelling adultsExcess relative riskBlood pressure variabilityExamined sleep qualityPoor sleep qualitySystolic blood pressure standard deviationSleep interruptionBody mass indexPhysical inactivityPrimary study outcomeStep countsImpact of sleep qualityLowest tertileRelative riskHigh blood pressure variabilityHome measurement devicesActivity levelsExposure statusPoor sleepMass indexStudy outcomes
2023
Disability Status and Secondary Prevention Among Survivors of Stroke: A Cross‐Sectional Analysis of the 2011 to 2018 National Health and Nutrition Examination Survey
Zhou T, de Havenon A, Sheth K, Ross J. Disability Status and Secondary Prevention Among Survivors of Stroke: A Cross‐Sectional Analysis of the 2011 to 2018 National Health and Nutrition Examination Survey. Journal Of The American Heart Association 2023, 12: e030869. PMID: 38014672, PMCID: PMC10727323, DOI: 10.1161/jaha.123.030869.Peer-Reviewed Original ResearchAssociation of Blood Pressure Variability With Death and Discharge Destination Among Critically Ill Patients With and Without Stroke
Stulberg E, Harris B, Zheutlin A, Delic A, Sheibani N, Anadani M, Yaghi S, Petersen N, de Havenon A. Association of Blood Pressure Variability With Death and Discharge Destination Among Critically Ill Patients With and Without Stroke. Neurology 2023, 101: e1145-e1157. PMID: 37487742, PMCID: PMC10513881, DOI: 10.1212/wnl.0000000000207599.Peer-Reviewed Original ResearchMeSH KeywordsAdultBlood PressureCritical IllnessHospital MortalityHumansPatient DischargeRetrospective StudiesStrokeConceptsAverage real variabilityNonstroke patientsDischarge destinationHospital deathIschemic strokeIll patientsIllness severityWorse outcomesAdult intensive care unit patientsMinimum mean arterial pressureIntensive care unit patientsIntensive Care III databaseBlood pressure goalsAcute ischemic strokeMean arterial pressureBlood pressure variabilityCare unit patientsRisk of deathMedical Information MartUnit patientsArterial pressureIntracerebral hemorrhageSubarachnoid hemorrhageRisk factorsEffect modificationPolygenic Susceptibility to Hypertension and Cognitive Performance in Middle-aged Persons Without Stroke or Dementia
Rivier C, Szejko N, Renedo D, Noche R, Acosta J, Both C, Sharma R, Torres-Lopez V, Payabvash S, de Havenon A, Sheth K, Gill T, Falcone G. Polygenic Susceptibility to Hypertension and Cognitive Performance in Middle-aged Persons Without Stroke or Dementia. Neurology 2023, 101: e512-e521. PMID: 37295956, PMCID: PMC10401683, DOI: 10.1212/wnl.0000000000207427.Peer-Reviewed Original ResearchPolygenic Susceptibility to Hypertension and Blood Pressure Control in Stroke Survivors
Acosta J, Both C, Demarais Z, Conlon C, Leasure A, Torres-Lopez V, de Havenon A, Petersen N, Gill T, Sansing L, Sheth K, Falcone G. Polygenic Susceptibility to Hypertension and Blood Pressure Control in Stroke Survivors. Neurology 2023, 100: e1587-e1597. PMID: 36690452, PMCID: PMC10103110, DOI: 10.1212/wnl.0000000000206763.Peer-Reviewed Original ResearchConceptsWorse BP controlUncontrolled blood pressureDiastolic blood pressureBlood pressureStroke survivorsPolygenic risk scoresBP controlPolygenic susceptibilityMean diastolic blood pressureMean systolic blood pressureStroke Prevention TrialBlood pressure controlSystolic blood pressureResistant hypertensionVascular eventsHemorrhagic strokePrevention trialsVitamin InterventionMultivariable modelRisk scoreGenetic predispositionPressure controlLogistic regressionSurvivorsHypertension
2022
Technical Dissonance in Home Blood Pressure Monitoring After Stroke: Having the Machine, but Not Using Correctly.
Forman R, Viscoli C, Meurer K, Sheth K, Sansing L, de Havenon A, Sharma R, Mariscal M, Kernan W. Technical Dissonance in Home Blood Pressure Monitoring After Stroke: Having the Machine, but Not Using Correctly. American Journal Of Hypertension 2022, 36: 195-200. PMID: 36520024, PMCID: PMC10016067, DOI: 10.1093/ajh/hpac129.Peer-Reviewed Original ResearchMeSH KeywordsBlood PressureBlood Pressure Monitoring, AmbulatoryCross-Sectional StudiesEthnicityHumansHypertensionConceptsHome blood pressure monitoringBlood pressure monitoringBlood pressurePressure monitoringNon-Hispanic white patientsProportion of patientsCross-sectional studyNon-Hispanic white participantsStroke recurrenceRate of useMost patientsPrimary outcomeWhite patientsRate of possessionPatientsUnderrepresented patientsArm cuffHypertensionStrokeCorrect useWhite participantsSignificant disparitiesEthnic groupsParticipantsQuality of techniqueInteraction of Mean Arterial Pressure and Blood Pressure Variability in Critically Ill Brain Injured Patients
de Havenon A, Petersen N, Stulberg E, Anadani M, Biffi A, Sheth K. Interaction of Mean Arterial Pressure and Blood Pressure Variability in Critically Ill Brain Injured Patients. Stroke 2022, 53: e512-e514. PMID: 36367101, PMCID: PMC9712254, DOI: 10.1161/strokeaha.122.041274.Peer-Reviewed Original ResearchBaseline Serum Biomarkers of Inflammation and Subsequent Visit-to-Visit Blood Pressure Variability: A Post Hoc Analysis of MESA
Wong KH, Muddasani V, Peterson C, Sheibani N, Arkin C, Cheong I, Majersik JJ, Biffi A, Petersen N, Falcone GJ, Sansing LH, de Havenon AH. Baseline Serum Biomarkers of Inflammation and Subsequent Visit-to-Visit Blood Pressure Variability: A Post Hoc Analysis of MESA. American Journal Of Hypertension 2022, 36: 144-147. PMID: 36315490, PMCID: PMC11484580, DOI: 10.1093/ajh/hpac122.Peer-Reviewed Original ResearchMeSH KeywordsAtherosclerosisBiomarkersBlood PressureFemaleHumansHypertensionInflammationInterleukin-6MaleMiddle AgedConceptsBlood pressure variabilityHigh blood pressure variabilitySerum inflammatory markersPlasmin-antiplasmin complexC-reactive proteinInterleukin-6Inflammatory markersBlood pressureStudy visitPressure variabilityBaseline serum IL-6Visit blood pressure variabilityLipid-lowering medicationsMean blood pressureSerum IL-6Markers of inflammationSystolic blood pressureBaseline study visitBody mass indexOnly IL-6Major vascular diseasesMulti-Ethnic StudyBaseline serum biomarkersPatient age categoryPost Hoc AnalysisSafety and efficacy of intensive systolic blood pressure lowering after successful endovascular therapy: a post hoc analysis of the BP TARGET trial
Anadani M, Maier B, Escalard S, Labreuche J, de Havenon A, Sabben C, Lapergue B, Mistry EA, Gory B, Spiotta AM, Richard S, Sibon I, Desilles JP, Blanc R, Piotin M, Mazighi M. Safety and efficacy of intensive systolic blood pressure lowering after successful endovascular therapy: a post hoc analysis of the BP TARGET trial. Journal Of NeuroInterventional Surgery 2022, 15: e142-e147. PMID: 36220337, DOI: 10.1136/jnis-2022-019130.Peer-Reviewed Original ResearchMeSH KeywordsBlood PressureBrain IschemiaEndovascular ProceduresHumansHypertensionStrokeTreatment OutcomeConceptsIntensive SBP treatmentHistory of hypertensionBlood pressure treatmentSuccessful endovascular therapyIntravenous thrombolysisLocation of occlusionEndovascular therapySBP treatmentAdmission SBPDiabetic patientsIntensive blood pressure loweringIntensive systolic blood pressureAcute ischemic stroke trialsTarget trialsEffect of SBPBlood pressure loweringNon-diabetic patientsFavorable functional outcomeSystolic blood pressureIschemic stroke trialsSite of occlusionIntensive SBPRecanalization statusSuccessful reperfusionBlood pressure
2021
Increased Blood Pressure Variability and the Risk of Probable Dementia or Mild Cognitive Impairment: A Post Hoc Analysis of the SPRINT MIND Trial
de Havenon A, Anadani M, Prabhakaran S, Wong K, Yaghi S, Rost N. Increased Blood Pressure Variability and the Risk of Probable Dementia or Mild Cognitive Impairment: A Post Hoc Analysis of the SPRINT MIND Trial. Journal Of The American Heart Association 2021, 10: e022206. PMID: 34533059, PMCID: PMC8649507, DOI: 10.1161/jaha.121.022206.Peer-Reviewed Original ResearchConceptsBlood pressure controlBlood pressure variabilityMild cognitive impairmentCognitive impairmentProbable dementiaMIND trialBlood pressurePressure variabilityExcellent blood pressure controlPressure controlSuboptimal blood pressure controlSystolic blood pressure variabilityCox proportional hazards modelRisk of dementiaBlood pressure measurementsProportional hazards modelRate of dementiaPost Hoc AnalysisLowest tertileHighest tertilePrimary outcomeCardiovascular diseaseHoc AnalysisCox modelHazards modelHispanic Ethnicity and Risk of Incident Cognitive Impairment in Relation to Systolic Blood Pressure
de Havenon A, Anadani M, Stulberg E, Rost N, Prabhakaran S, Sheth KN. Hispanic Ethnicity and Risk of Incident Cognitive Impairment in Relation to Systolic Blood Pressure. Hypertension 2021, 78: 1665-1666. PMID: 34365813, PMCID: PMC8516701, DOI: 10.1161/hypertensionaha.121.17599.Peer-Reviewed Original ResearchMidlife Blood Pressure Variability and Risk of All-Cause Mortality and Cardiovascular Events During Extended Follow-up
de Havenon A, Delic A, Yaghi S, Wong KH, Majersik JJ, Stulberg E, Tirschwell D, Anadani M. Midlife Blood Pressure Variability and Risk of All-Cause Mortality and Cardiovascular Events During Extended Follow-up. American Journal Of Hypertension 2021, 34: 1269-1275. PMID: 34240111, PMCID: PMC8643578, DOI: 10.1093/ajh/hpab106.Peer-Reviewed Original ResearchConceptsBlood pressure variabilityLong-term blood pressure variabilityCardiovascular eventsHazard ratioPressure variabilityCardiovascular disease-free participantsMean systolic blood pressureVisit blood pressure variabilityCox proportional hazards modelCardiovascular risk factorsCorresponding hazard ratiosCongestive heart failureDisease-free patientsSystolic blood pressureDisease-free participantsProportional hazards modelPrior strokeCause mortalitySecondary outcomesBlood pressureHeart failureIndependent predictorsPrimary outcomeVisit 4Mean ageEvaluation of Systolic Blood Pressure, Use of Aspirin and Clopidogrel, and Stroke Recurrence in the Platelet-Oriented Inhibition in New TIA and Minor Ischemic Stroke Trial
de Havenon A, Johnston SC, Easton JD, Kim AS, Sheth KN, Lansberg M, Tirschwell D, Mistry E, Yaghi S. Evaluation of Systolic Blood Pressure, Use of Aspirin and Clopidogrel, and Stroke Recurrence in the Platelet-Oriented Inhibition in New TIA and Minor Ischemic Stroke Trial. JAMA Network Open 2021, 4: e2112551. PMID: 34086033, PMCID: PMC8178708, DOI: 10.1001/jamanetworkopen.2021.12551.Peer-Reviewed Original ResearchConceptsBaseline systolic blood pressureDual antiplatelet therapySystolic blood pressureTransient ischemic attackMinor Ischemic Stroke (POINT) trialNew transient ischemic attackAcute ischemic strokeIschemic strokeIschemic stroke trialsStroke recurrenceHazard ratioBlood pressurePrimary outcomeStroke trialsElevated baseline systolic blood pressureFit Cox proportional hazards modelsHigher baseline systolic blood pressureElevated systolic blood pressureCox proportional hazards modelDays of randomizationFuture stroke riskIschemic stroke recurrenceUse of aspirinSubgroup of patientsProportional hazards modelBlood Pressure Management After Endovascular Therapy
Anadani M, de Havenon A, Mistry E, Anderson CS. Blood Pressure Management After Endovascular Therapy. Stroke 2021, 52: e263-e265. PMID: 34000832, PMCID: PMC8191365, DOI: 10.1161/strokeaha.121.034995.Peer-Reviewed Original ResearchMagnitude of blood pressure change and clinical outcomes after thrombectomy in stroke caused by large artery occlusion
Anadani M, Matusevicius M, Tsivgoulis G, Peeters A, Nunes A, Mancuso M, Roffe C, de Havenon A, Ahmed N. Magnitude of blood pressure change and clinical outcomes after thrombectomy in stroke caused by large artery occlusion. European Journal Of Neurology 2021, 28: 1922-1930. PMID: 33682232, DOI: 10.1111/ene.14807.Peer-Reviewed Original ResearchMeSH KeywordsAgedArteriesBlood PressureBrain IschemiaFemaleHumansMaleRetrospective StudiesStrokeThrombectomyTreatment OutcomeConceptsSystolic blood pressureAssociated with unfavorable outcomesRestricted cubic spline modelsUnfavorable outcomeLow systolic blood pressureRestricted cubic splinesCubic spline modelsLogistic regression modelsMixed logistic regression modelsArtery occlusion strokeMultivariable mixed logistic regression modelsMechanical thrombectomyAssociated with poor functional outcomeSBP increaseAdmission systolic blood pressureHigher SBPPoor functional outcomeMagnitude of blood pressure changesPredictors of unfavorable outcomeIncreased risk of unfavorable outcomeOcclusion strokePrimary outcomeSBP changeRisk of unfavorable outcomeStudy populationBlood Pressure Management Before, During, and After Endovascular Thrombectomy for Acute Ischemic Stroke
de Havenon A, Petersen N, Sultan-Qurraie A, Alexander M, Yaghi S, Park M, Grandhi R, Mistry E. Blood Pressure Management Before, During, and After Endovascular Thrombectomy for Acute Ischemic Stroke. Seminars In Neurology 2021, 41: 046-053. PMID: 33472269, PMCID: PMC8063274, DOI: 10.1055/s-0040-1722721.Peer-Reviewed Original ResearchConceptsBlood pressure managementEndovascular thrombectomyBlood pressurePressure managementLarge vessel occlusion stroke patientsMaximum systolic blood pressureOptimal blood pressure managementAmerican Heart Association guidelinesAcute ischemic strokeHeart Association guidelinesSystolic blood pressurePenumbral perfusionSuccessful recanalizationIschemic strokeGuideline recommendationsStroke patientsHyperacute phaseAssociation guidelinesPatient outcomesClinical scenariosThrombectomyRecanalizationPatientsHgSpecific evidence
2020
Blood pressure reduction and outcome after endovascular therapy: a secondary analysis of the BEST study
Anadani M, de Havenon A, Yaghi S, Mehta T, Arora N, Starosciak AK, La Rosa F, Siegler J, Mistry AM, Chitale R, Spiotta AM, Tsivgoulis G, Khatri P, Mistry EA. Blood pressure reduction and outcome after endovascular therapy: a secondary analysis of the BEST study. Journal Of NeuroInterventional Surgery 2020, 13: 698-702. PMID: 32883780, PMCID: PMC8088286, DOI: 10.1136/neurintsurg-2020-016494.Peer-Reviewed Original ResearchConceptsSystolic blood pressure reductionSystolic blood pressureBlood pressure reductionEndovascular therapyPoor functional outcomeSuccessful recanalizationBlood pressurePoor outcomeFunctional outcomeOutcome groupAdmission systolic blood pressureOutcomes of EVTProspective observational cohort studyBaseline systolic blood pressureElevated systolic blood pressurePressure reductionHistory of hypertensionObservational cohort studyPoor outcome groupProspective multicenter cohortGood outcome groupAntihypertensive treatmentRevascularization statusCohort studyMulticenter cohortPulse pressure variability is associated with unfavorable outcomes in acute ischaemic stroke patients treated with intravenous thrombolysis
Katsanos A, Alexandrov A, Mandava P, Köhrmann M, Soinne L, Barreto A, Sharma V, Mikulik R, Muir K, Rothlisberger T, Grotta J, Levi C, Molina C, Saqqur M, Palaiodimou L, Psaltopoulou T, Vosko M, Moreira T, Fiebach J, Rubiera M, Sandset E, de Havenon A, Kent T, Alexandrov A, Schellinger P, Tsivgoulis G, Investigators F. Pulse pressure variability is associated with unfavorable outcomes in acute ischaemic stroke patients treated with intravenous thrombolysis. European Journal Of Neurology 2020, 27: 2453-2462. PMID: 32697894, DOI: 10.1111/ene.14447.Peer-Reviewed Original ResearchConceptsPatients treated with intravenous thrombolysisAcute ischaemic strokeIndependent functional outcomePulse pressure variabilityIntravenous thrombolysisIntracranial bleedingAssociated with adverse short-termFunctional outcomesBlood pressureStroke patients treated with intravenous thrombolysisTissue plasminogen activator bolusSystemic tissue plasminogen activatorAssociated with unfavorable outcomesAssociated with worse neurological outcomeSymptomatic intracranial bleedingLong-term functional outcomeSafety end pointPulse pressureAcute ischaemic stroke patientsAdverse short-termLysis of thrombiPressure variabilityTissue plasminogen activatorCombined Lysis of ThrombusIntravenous thrombolysis administration
2019
Blood Pressure Variability and Neurologic Outcome After Endovascular Thrombectomy
Mistry EA, Mehta T, Mistry A, Arora N, Starosciak AK, De Los Rios La Rosa F, Siegler JE, Chitale R, Anadani M, Yaghi S, Khatri P, de Havenon A. Blood Pressure Variability and Neurologic Outcome After Endovascular Thrombectomy. Stroke 2019, 51: 511-518. PMID: 31813361, PMCID: PMC8010595, DOI: 10.1161/strokeaha.119.027549.Peer-Reviewed Original ResearchConceptsHigh blood pressure variabilityBlood pressure variabilitySystolic blood pressure variabilityEndovascular treatmentPoor outcomeStroke patientsPressure variabilityAnterior circulation acute ischemic stroke patientsLower systolic blood pressure variabilityMeasure of BPVAcute ischemic stroke patientsDiastolic blood pressure variabilityLogistic regressionLarge vessel occlusion strokeMulticenter cohort studyIschemic stroke patientsWorse functional outcomeRate of deathNeurologic outcomeNeurological outcomeCohort studyEndovascular thrombectomyDiastolic BPHighest tertileOcclusion stroke