2024
External validation of the SI2NCAL2C score for outcomes following cerebral venous thrombosis
Klein P, Shu L, Lindgren E, de Winter M, Siegler J, Simpkins A, Omran S, Heldner M, de Havenon A, Abdalkader M, Al Kasab S, Stretz C, Wu T, Wilson D, Asad S, Almallouhi E, Frontera J, Kuohn L, Rothstein A, Bakradze E, Henninger N, Zubair A, Sharma R, Kerrigan D, Aziz Y, Mistry E, van Kammen M, Tatlisumak T, Krzywicka K, Aguiar de Sousa D, Jood K, Field T, Yaghi S, Coutinho J, Nguyen T. External validation of the SI2NCAL2C score for outcomes following cerebral venous thrombosis. Journal Of Stroke And Cerebrovascular Diseases 2024, 33: 107720. PMID: 38614162, DOI: 10.1016/j.jstrokecerebrovasdis.2024.107720.Peer-Reviewed Original ResearchConceptsCerebral venous thrombosisArea under the receiver operating characteristic curvePoor outcomeVenous thrombosisCentral nervous system infectionInternational retrospective studyNervous system infectionExternal validation cohortFocal neurological deficitsReceiver operating characteristic curvePoor outcome dataLevels of hemoglobinLack of follow-upPoorer outcome scoresConsecutive patientsClinical presentationRetrospective studyValidation cohortIntracerebral hemorrhageNeurological deficitsFollow-upOutcome scoresSystemic infectionLevels of glucoseInternational cohort
2021
Investigating the “Weekend Effect” on Outcomes of Patients Undergoing Endovascular Mechanical Thrombectomy for Ischemic Stroke
Grandhi R, Ravindra VM, Ney JP, Zaidat O, Taussky P, de Havenon A. Investigating the “Weekend Effect” on Outcomes of Patients Undergoing Endovascular Mechanical Thrombectomy for Ischemic Stroke. Journal Of Stroke And Cerebrovascular Diseases 2021, 30: 106013. PMID: 34375859, PMCID: PMC8511062, DOI: 10.1016/j.jstrokecerebrovasdis.2021.106013.Peer-Reviewed Original ResearchMeSH KeywordsAfter-Hours CareAgedAged, 80 and overCross-Sectional StudiesDatabases, FactualEndovascular ProceduresFemaleHospital CostsHospital MortalityHumansInpatientsIschemic StrokeLength of StayMaleMiddle AgedPatient DischargeRetrospective StudiesRisk AssessmentRisk FactorsThrombectomyTime FactorsTreatment OutcomeUnited StatesConceptsAcute ischemic strokeEndovascular thrombectomyIschemic strokeLarge vessel occlusion ischemic strokeHealth Stroke Scale scoreNationwide Inpatient Sample dataStroke Scale scoreExtended hospital stayWorse clinical outcomesCross-sectional analysisLogistic regression modelsHospital deathHospital staySecondary outcomesPrimary outcomeClinical outcomesAIS patientsNormal working hoursPatientsScale scoreFavorable dischargeExposure variablesStrokeWeekends/National InstitutePredicting 90-Day Outcome After Thrombectomy: Baseline-Adjusted 24-Hour NIHSS Is More Powerful Than NIHSS Score Change
Mistry EA, Yeatts S, de Havenon A, Mehta T, Arora N, La Rosa F, Starosciak AK, Siegler JE, Mistry AM, Yaghi S, Khatri P. Predicting 90-Day Outcome After Thrombectomy: Baseline-Adjusted 24-Hour NIHSS Is More Powerful Than NIHSS Score Change. Stroke 2021, 52: 2547-2553. PMID: 34000830, PMCID: PMC11261999, DOI: 10.1161/strokeaha.120.032487.Peer-Reviewed Original ResearchConceptsNIHSS scoreLong-term functional outcomeNIHSS score changeComprehensive stroke centerHealth Stroke ScaleProspective observational studyEarly time pointsStroke centersStroke ScaleEndovascular therapyMRS outcomesMRS scoreRankin ScaleStroke patientsFunctional outcomeSurrogate markerClinical studiesNIHSSMultivariable modelingObservational studyOutcome measuresPatientsPercent changeScore changeLogistic regressionWhite Matter Hyperintensity and Cardiovascular Disease Outcomes in the SPRINT MIND Trial
Sheibani N, Wong KH, Turan TN, Yeatts SD, Gottesman RF, Prabhakaran S, Rost NS, de Havenon A. White Matter Hyperintensity and Cardiovascular Disease Outcomes in the SPRINT MIND Trial. Journal Of Stroke And Cerebrovascular Diseases 2021, 30: 105764. PMID: 33823461, PMCID: PMC8107132, DOI: 10.1016/j.jstrokecerebrovasdis.2021.105764.Peer-Reviewed Original ResearchConceptsSystolic Blood Pressure Intervention TrialWhite matter hyperintensity volumeSystolic blood pressurePrimary outcomeHazard ratioLog-transformed white matter hyperintensity volumeGoal systolic blood pressureLog-transformed continuous variableComposite of strokeIntensive BP loweringHigh cardiovascular riskAcute coronary syndromeCongestive heart failureProspective clinical trialsCardiovascular disease outcomesFuture CVD riskWhite matter hyperintensitiesSubset of participantsBP loweringCardiovascular deathCardiovascular eventsCoronary syndromeCardiovascular riskCVD riskBlood pressure
2020
Impact of Intracranial Pressure Monitor–Guided Therapy on Neurologic Outcome After Spontaneous Nontraumatic Intracranial Hemorrhage
Menacho ST, Grandhi R, Delic A, Anadani M, Ziai WC, Awad IA, Hanley DF, de Havenon A. Impact of Intracranial Pressure Monitor–Guided Therapy on Neurologic Outcome After Spontaneous Nontraumatic Intracranial Hemorrhage. Journal Of Stroke And Cerebrovascular Diseases 2020, 30: 105540. PMID: 33360250, PMCID: PMC8080544, DOI: 10.1016/j.jstrokecerebrovasdis.2020.105540.Peer-Reviewed Original ResearchMeSH KeywordsAgedClinical Trials, Phase III as TopicDatabases, FactualFemaleHumansIntracranial HemorrhagesIntracranial PressureMaleMiddle AgedMonitoring, PhysiologicPredictive Value of TestsRandomized Controlled Trials as TopicRecovery of FunctionRisk AssessmentRisk FactorsTime FactorsTreatment OutcomeConceptsICP monitor placementNontraumatic intracranial hemorrhageIntracranial hemorrhageIntracranial pressure monitorPoor outcomeNeurologic outcomePressure monitorPropensity score-matched cohortMonitor placementIdentification of patientsSpontaneous intracranial hemorrhageExternal ventricular drainInvasive ICP monitoringLogistic regression modelsIntraparenchymal monitorsIII trialsSecondary outcomesPrimary outcomeBalanced cohortVentricular drainICP monitorICP monitoringPatientsSecondary analysisGreater riskImpact of COVID-19 on Outcomes in Ischemic Stroke Patients in the United States
de Havenon A, Ney JP, Callaghan B, Delic A, Hohmann S, Shippey E, Esper GJ, Stulberg E, Tirschwell D, Frontera J, Yaghi S, Anadani M, Majersik JJ. Impact of COVID-19 on Outcomes in Ischemic Stroke Patients in the United States. Journal Of Stroke And Cerebrovascular Diseases 2020, 30: 105535. PMID: 33310595, PMCID: PMC7832426, DOI: 10.1016/j.jstrokecerebrovasdis.2020.105535.Peer-Reviewed Original ResearchConceptsIschemic stroke patientsIschemic strokeFavorable dischargeStroke patientsPrimary analysisLaboratory-confirmed COVID-19COVID-19Vizient Clinical Data BaseAcute coronary syndromeAcute renal failureCohort of patientsCoronavirus disease 2019Clinical data baseCoronary syndromeHospital deathVenous thromboembolismMechanical thrombectomyRenal failureHispanic patientsDischarge diagnosisSubarachnoid hemorrhageWorse outcomesDisease 2019High riskLower oddsThe Effect of Hyperglycemia on Infarct Growth after Reperfusion: An Analysis of the DEFUSE 3 trial
Yaghi S, Dehkharghani S, Raz E, Jayaraman M, Tanweer O, Grory BM, Henninger N, Lansberg MG, Albers GW, Havenon A. The Effect of Hyperglycemia on Infarct Growth after Reperfusion: An Analysis of the DEFUSE 3 trial. Journal Of Stroke And Cerebrovascular Diseases 2020, 30: 105380. PMID: 33166769, PMCID: PMC7736545, DOI: 10.1016/j.jstrokecerebrovasdis.2020.105380.Peer-Reviewed Original ResearchConceptsDEFUSE-3 trialsBaseline glucose levelsInfarct growthGlucose levelsPrimary outcomeAcute ischemic stroke patientsAggressive glycemic controlDEFUSE 3 patientsIschemic core volumePotential neuroprotective benefitsIschemic stroke patientsGood functional outcomeLarge vessel occlusionEffects of hyperglycemiaSuccessful endovascular reperfusionAdmission glucoseInfarction growthEndovascular reperfusionSuccessful reperfusionTICI 2bIschemic strokeNeuroprotective benefitsEndovascular therapyGlycemic controlStroke patientsAcute stroke care in a New York City comprehensive stroke center during the COVID-19 pandemic
Agarwal S, Scher E, Rossan-Raghunath N, Marolia D, Butnar M, Torres J, Zhang C, Kim S, Sanger M, Humbert K, Tanweer O, Shapiro M, Raz E, Nossek E, Nelson PK, Riina HA, de Havenon A, Wachs M, Farkas J, Tiwari A, Arcot K, Parella DT, Liff J, Wu T, Wittman I, Caldwell R, Frontera J, Lord A, Ishida K, Yaghi S. Acute stroke care in a New York City comprehensive stroke center during the COVID-19 pandemic. Journal Of Stroke And Cerebrovascular Diseases 2020, 29: 105068. PMID: 32807471, PMCID: PMC7305900, DOI: 10.1016/j.jstrokecerebrovasdis.2020.105068.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overBetacoronavirusComprehensive Health CareCoronavirus InfectionsCOVID-19Critical PathwaysDelivery of Health Care, IntegratedFemaleHumansMaleMiddle AgedNew York CityPandemicsPatient Care TeamPneumonia, ViralQuality ImprovementQuality Indicators, Health CareRegistriesRetrospective StudiesSARS-CoV-2StrokeThrombectomyThrombolytic TherapyTime FactorsTime-to-TreatmentTreatment OutcomeWorkflowConceptsComprehensive stroke centerAcute ischemic strokePre-pandemic groupAIS patientsStroke centersTransient ischemic attack/strokeAcute stroke processDefect-free careLonger median doorEmergency health care servicesAcute stroke careConsecutive AIS patientsQuality improvement registrySuccessful recanalization rateLong-term outcomesQuality of careHealth care servicesCOVID-19 screeningAcute strokeIschemic strokeLonger doorMechanical thrombectomyMedian doorStroke severityDischarge outcomesFactors associated with therapeutic anticoagulation status in patients with ischemic stroke and atrial fibrillation
Yaghi S, Liberman AL, Henninger N, Grory BM, Nouh A, Scher E, Giles J, Liu A, Nagy M, Kaushal A, Azher I, Fakhri H, Espaillat KB, Asad SD, Pasupuleti H, Martin H, Tan J, Veerasamy M, Esenwa C, Cheng N, Moncrieffe K, Moeini-Naghani I, Siddu M, Trivedi T, Ishida K, Frontera J, Lord A, Furie K, Keyrouz S, de Havenon A, Mistry E, Leon Guerrero CR, Khan M. Factors associated with therapeutic anticoagulation status in patients with ischemic stroke and atrial fibrillation. Journal Of Stroke And Cerebrovascular Diseases 2020, 29: 104888. PMID: 32414583, PMCID: PMC8207529, DOI: 10.1016/j.jstrokecerebrovasdis.2020.104888.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAnticoagulantsAtrial FibrillationBlood CoagulationBrain IschemiaDrug MonitoringFemaleHumansInternational Normalized RatioIntracranial ArteriosclerosisMaleRecurrenceRegistriesRetrospective StudiesRisk AssessmentRisk FactorsStrokeTime FactorsTreatment OutcomeUnited StatesWarfarinConceptsStroke prevention strategiesIschemic strokeAtrial fibrillationAnticoagulation statusMore narrowingStroke sizeStroke mechanismPrevention strategiesSetting of AFInitiation of anticoagulationComprehensive stroke centerAcute ischemic strokeDirect oral anticoagulantsIschemic stroke mechanismLogistic regression modelsBinary logistic regression modelIndex strokeSubtherapeutic INRTherapeutic anticoagulationOral anticoagulantsStroke RegistryAnticoagulant statusStroke centersConsecutive patientsLuminal narrowingPoststroke Montreal Cognitive Assessment and Recurrent Stroke in Patients With Symptomatic Intracranial Atherosclerosis
Yaghi S, Cotsonis G, de Havenon A, Prahbakaran S, Romano JG, Lazar RM, Marshall RS, Feldmann E, Liebeskind DS. Poststroke Montreal Cognitive Assessment and Recurrent Stroke in Patients With Symptomatic Intracranial Atherosclerosis. Journal Of Stroke And Cerebrovascular Diseases 2020, 29: 104663. PMID: 32044220, PMCID: PMC8985650, DOI: 10.1016/j.jstrokecerebrovasdis.2020.104663.Peer-Reviewed Original ResearchConceptsMontreal Cognitive AssessmentRecurrent ischemic strokeRecurrent strokeIschemic strokeCognitive impairmentMultivariable Cox regression modelsCognitive AssessmentAggressive medical therapyAnterior circulation stenosisIntracranial Stenosis (SAMMPRIS) trialPreventing Recurrent StrokeStroke recurrence riskLong-term morbiditySymptomatic intracranial atherosclerosisCox regression modelPoststroke cognitive impairmentMean followStroke recurrenceIntracranial atherosclerosisMedical therapyPrimary outcomeArtery stenosisIntracranial stenosisStroke patientsMean age
2019
Effect of Time Elapsed since Gadolinium Administration on Atherosclerotic Plaque Enhancement in Clinical Vessel Wall MR Imaging Studies
de Havenon A, Muhina HJ, Parker DL, McNally JS, Alexander MD. Effect of Time Elapsed since Gadolinium Administration on Atherosclerotic Plaque Enhancement in Clinical Vessel Wall MR Imaging Studies. American Journal Of Neuroradiology 2019, 40: 1709-1711. PMID: 31515211, PMCID: PMC6785399, DOI: 10.3174/ajnr.a6191.Peer-Reviewed Original ResearchConceptsIntracranial atherosclerotic diseaseAtherosclerotic diseaseContrast administrationMR imaging studiesVessel wall MR imagingSignal intensity changesPlaque enhancementGadolinium administrationVessel wall MRImaging studiesMR imagingLonger durationAdministrationGreater increaseDiseaseDurationCohortTime ElapsedDiurnal Variations in the First 24/7 Mobile Stroke Unit
Zaidat OO, Changal KH, Sultan-Qurraie A, de Havenon A, Calderon VJ, Goins-Whitmore J, Patterson MS, Lin E. Diurnal Variations in the First 24/7 Mobile Stroke Unit. Stroke 2019, 50: 1911-1914. PMID: 31104620, DOI: 10.1161/strokeaha.119.024950.Peer-Reviewed Original ResearchConceptsStroke unitResults One hundred ninetyEvening shiftsMorning shiftPrehospital stroke careMobile stroke unitMSU patientsProspective databaseIntravenous thrombolyticsMechanical thrombectomyPatient characteristicsStroke treatmentStroke careTreatment metricsTherapeutic interventionsNocturnal shiftPatients
2017
Determinants of the impact of blood pressure variability on neurological outcome after acute ischaemic stroke
de Havenon A, Bennett A, Stoddard GJ, Smith G, Chung L, O'Donnell S, McNally JS, Tirschwell D, Majersik JJ. Determinants of the impact of blood pressure variability on neurological outcome after acute ischaemic stroke. Stroke And Vascular Neurology 2017, 2: 1. PMID: 28959484, PMCID: PMC5435214, DOI: 10.1136/svn-2016-000057.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedBlood PressureBlood Pressure DeterminationCerebral AngiographyCerebrovascular CirculationCollateral CirculationComputed Tomography AngiographyDisability EvaluationFemaleHumansIschemic StrokeMaleMiddle AgedNeuroimagingPatient AdmissionPerfusion ImagingPredictive Value of TestsPrognosisRecovery of FunctionRetrospective StudiesRisk FactorsTime FactorsConceptsBlood pressure variabilityProximal vessel occlusionAcute ischemic strokeIschemic strokeVessel occlusionNeurological outcomeBPV indicesPressure variabilityAcute anterior circulation ischemic strokeAnterior circulation ischemic strokeIntravenous tissue plasminogen activatorGood collateral vesselsIschemic core volumeLarger mismatch volumeWorse neurological outcomeAcute stroke therapySubset of patientsSystolic blood pressureTissue plasminogen activatorLogistic regression modelsOrdinal logistic regression modelsEndovascular thrombectomyIschemic penumbraStroke onsetStroke outcome