2023
Composition, Treatment, and Outcomes by Radiologically Defined Thrombus Characteristics in Acute Ischemic Stroke
Das S, Goldstein E, de Havenon A, Abbasi M, Nguyen T, de Sousa D, Yaghi S. Composition, Treatment, and Outcomes by Radiologically Defined Thrombus Characteristics in Acute Ischemic Stroke. Stroke 2023, 54: 1685-1694. PMID: 36661035, DOI: 10.1161/strokeaha.122.038563.Peer-Reviewed Original ResearchConceptsAcute ischemic strokeIschemic strokeAdvanced imaging modalitiesStroke treatmentOcclusive thrombusThrombus characteristicsTreatment modalitiesArterial thrombiNeurovascular imagingClot compositionPrevention strategiesTherapy modalitiesThrombusImaging modalitiesPatientsStrokeModalitiesFuture studiesFurther testingTreatmentReview articleClassification systemPathomechanismEpidemiologyImportant clues
2021
Penumbra Consumption Rates Based on Time-to-Maximum Delay and Reperfusion Status: A Post Hoc Analysis of the DEFUSE 3 Trial
Yaghi S, Raz E, Dehkharghani S, Riina H, McTaggart R, Jayaraman M, Prabhakaran S, Liebeskind DS, Khatri P, Mac Grory B, Al-Mufti F, Lansberg M, Albers G, de Havenon A. Penumbra Consumption Rates Based on Time-to-Maximum Delay and Reperfusion Status: A Post Hoc Analysis of the DEFUSE 3 Trial. Stroke 2021, 52: 2690-2693. PMID: 34157865, DOI: 10.1161/strokeaha.120.033806.Peer-Reviewed Original ResearchConceptsDEFUSE-3 trialsLarge vessel occlusionPenumbral tissueVessel occlusionMismatch volumeAcute large vessel occlusionAnterior circulation occlusionEndovascular thrombectomy patientsAcute ischemic strokePost Hoc AnalysisReperfusion statusThrombectomy patientsTICI 0Cerebral infarctionEndovascular thrombectomyIschemic strokeUntreated patientsPrimary outcomeSalvageable tissueTreatment modalitiesHoc AnalysisPerfusion timePatientsNatural historyOcclusion