2023
Understanding Patterns of Missingness in Acute Ischemic Stroke Trials: A Secondary Analysis of Pooled Participant-Level Follow-Up Data
de Havenon A, Bangad A, Skolarus L, Aldridge C, Braun R, Cole J, Cramer S, Lindgren A, Sunmonu N, Worrall B, Lohse K. Understanding Patterns of Missingness in Acute Ischemic Stroke Trials: A Secondary Analysis of Pooled Participant-Level Follow-Up Data. Stroke 2023, 54: e201-e202. PMID: 36896708, PMCID: PMC10133020, DOI: 10.1161/strokeaha.122.042168.Peer-Reviewed Original Research
2022
Subsequent ischemic stroke and tobacco smoking: A secondary analysis of the POINT trial
Lang A, de Havenon A, Mac Grory B, Henninger N, Shu L, Furie K, Easton J, Kim A, Johnston S, Yaghi S. Subsequent ischemic stroke and tobacco smoking: A secondary analysis of the POINT trial. European Stroke Journal 2022, 8: 328-333. PMID: 37021190, PMCID: PMC10069178, DOI: 10.1177/23969873221148224.Peer-Reviewed Original ResearchConceptsSubsequent ischemic strokeEffect of clopidogrelSubsequent stroke riskIschemic strokeMajor hemorrhagePoint trialStroke riskSmoking statusMinor Ischemic Stroke (POINT) trialSubgroup interaction analysesMultivariable Cox regressionMinor ischemic strokeIschemic stroke trialsEffect of smokingNon-significant trendNew TIACurrent smokersStroke trialsTobacco smokingCox regressionIndex eventSmokersSecondary analysisClopidogrelStroke
2021
Evaluation of Systolic Blood Pressure, Use of Aspirin and Clopidogrel, and Stroke Recurrence in the Platelet-Oriented Inhibition in New TIA and Minor Ischemic Stroke Trial
de Havenon A, Johnston SC, Easton JD, Kim AS, Sheth KN, Lansberg M, Tirschwell D, Mistry E, Yaghi S. Evaluation of Systolic Blood Pressure, Use of Aspirin and Clopidogrel, and Stroke Recurrence in the Platelet-Oriented Inhibition in New TIA and Minor Ischemic Stroke Trial. JAMA Network Open 2021, 4: e2112551. PMID: 34086033, PMCID: PMC8178708, DOI: 10.1001/jamanetworkopen.2021.12551.Peer-Reviewed Original ResearchConceptsBaseline systolic blood pressureDual antiplatelet therapySystolic blood pressureTransient ischemic attackMinor Ischemic Stroke (POINT) trialNew transient ischemic attackAcute ischemic strokeIschemic strokeIschemic stroke trialsStroke recurrenceHazard ratioBlood pressurePrimary outcomeStroke trialsElevated baseline systolic blood pressureFit Cox proportional hazards modelsHigher baseline systolic blood pressureElevated systolic blood pressureCox proportional hazards modelDays of randomizationFuture stroke riskIschemic stroke recurrenceUse of aspirinSubgroup of patientsProportional hazards modelVariability of the Modified Rankin Scale Score Between Day 90 and 1 Year After Ischemic Stroke
de Havenon A, Tirschwell DL, Heitsch L, Cramer SC, Braun R, Cole J, Reddy V, Majersik JJ, Lindgren A, Worrall BB. Variability of the Modified Rankin Scale Score Between Day 90 and 1 Year After Ischemic Stroke. Neurology Clinical Practice 2021, 11: e239-e244. PMID: 34484897, PMCID: PMC8382369, DOI: 10.1212/cpj.0000000000000954.Peer-Reviewed Original ResearchModified Rankin ScaleTrial's primary outcomePrimary outcomeIschemic strokeDay 90Stroke onsetStroke trialsStroke (NINDS) rt-PA Stroke StudyModified Rankin Scale scoreAcute ischemic strokeProportion of patientsIschemic stroke onsetRankin Scale scoreClinical trial designTraditional outcome measuresMRS improvementMRS shiftStroke IIIRecurrent strokeRankin ScaleInterventional managementClinical evolutionStroke StudyRehabilitative therapyAlbumin treatment
2019
SEIMLESS: Simultaneous Extracranial, Intracranial Management of (tandem) LESsions in Stroke
Sultan-Qurraie A, Witt T, de Havenon A, Ribo M, Zaidat OO. SEIMLESS: Simultaneous Extracranial, Intracranial Management of (tandem) LESsions in Stroke. Journal Of NeuroInterventional Surgery 2019, 11: 879. PMID: 30674634, DOI: 10.1136/neurintsurg-2018-014403.Peer-Reviewed Original ResearchConceptsTandem lesionsAcute ischemic stroke patientsCerebral Infarction scoreDistal intracranial occlusionsPost-procedural ThrombolysisIschemic stroke patientsIntracranial arterial occlusionTotal fluoroscopy timeCase-control studyAmount of contrastIntracranial recanalizationEndovascular thrombectomyRecanalization timeArterial punctureIntracranial occlusionArterial occlusionStroke patientsStroke trialsArterial accessConcomitant occlusionDistal lesionsFluoroscopy timeClinical dataProximal vesselsPatients